H2AFX (англ.H2A histone family member X) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 11-ї хромосоми.[3] Довжина поліпептидного ланцюга білка становить 143амінокислот, амолекулярна маса — 15 145[4].
Mannironi C., Bonner W.M., Hatch C.L. (1989). H2A.X. a histone isoprotein with a conserved C-terminal sequence, is encoded by a novel mRNA with both DNA replication type and polyA 3' processing signals.Nucleic Acids Res.17: 9113—9126.PMID2587254doi:10.1093/nar/17.22.9113
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).Genome Res.14: 2121—2127. 2004.PMID15489334doi:10.1101/gr.2596504
Rogakou E.P., Boon C., Redon C., Bonner W.M. (1999). Megabase chromatin domains involved in DNA double-strand breaks in vivo.J. Cell Biol.146: 905—916.PMID10477747doi:10.1083/jcb.146.5.905
Rogakou E.P., Nieves-Neira W., Boon C., Pommier Y., Bonner W.M. (2000). Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139.J. Biol. Chem.275: 9390—9395.PMID10734083doi:10.1074/jbc.275.13.9390
Ward I.M., Chen J. (2001). Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress.J. Biol. Chem.276: 47759—47762.PMID11673449doi:10.1074/jbc.C100569200
