"The exact process of how an Altered Item is born eludes us. We find them in the aftermath of Altered World Events. They take the form of everyday objects — ever-present in our lives, constantly evoked in the thoughts of millions of people. Now infused with unpredictable energies, they're altered. The superstitious would call them cursed."
Maybe Magic, Maybe Mundane: It's left ambiguous whether a situation or person believed to be supernatural in nature actually has a logical explanation for the weirdness or is genuinely supernatural.
Medicate the Medium: Someone's visions of dead people are mistaken for hallucinations, and they receive medical treatment on this basis.
Supernaturally Validated Trans Person: A magical effect dependent on gender affects a trans person based on their identity rather than their sex at birth.