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Wikipedia
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FXN

Wikipedia — ирекле энциклопедия проектыннан ([http://tt.wikipedia.org.ttcysuttlart1999.aylandirow.tmf.org.ru/wiki/FXN latin yazuında])
FXN
Нинди таксонда барH. sapiens[d][1]
Кодлаучы генФратаксин[d][1]
Молекуляр функциясвязывание с белками плазмы[d][2][3][4],iron chaperone activity[d][5],2 iron, 2 sulfur cluster binding[d][6],oxidoreductase activity[d][7],ferrous iron binding[d][8][5][6],связывание с ионом металла[d][7],ferric iron binding[d][9][6][10],ferroxidase activity[d][9][9][11],ferroxidase activity[d][7][7][12][…],ferrous iron binding[d][13][14][4][…],ferric iron binding[d][7][13][15][…],iron chaperone activity[d][4][16] һәм2 iron, 2 sulfur cluster binding[d][13][16]
Күзәнәк компонентыцитоплазма[7],цитозоль[d][7][17],митохондриальный матрикс[d][7][14][7],митохондрия[9][9][18],L-cysteine desulfurase complex[d][19] һәммитохондрия[7][7][7][…]
Биологик процессregulation of ferrochelatase activity[d][4],позитивная регуляция пролиферации клеток[d][20],response to iron ion[d][21],iron-sulfur cluster assembly[d][9],ion transport[d][7],positive regulation of aconitate hydratase activity[d][20],positive regulation of cell growth[d][22],cellular response to hydrogen peroxide[d][12],negative regulation of release of cytochrome c from mitochondria[d][23],positive regulation of succinate dehydrogenase activity[d][20],protein autoprocessing[d][13],негативная регуляция апоптоза[d][23],small molecule metabolic process[d][7],iron ion homeostasis[d][7],iron incorporation into metallo-sulfur cluster[d][6],cellular iron ion homeostasis[d][24][9],Биосинтез гема[d][4][7],positive regulation of lyase activity[d][20][25],positive regulation of catalytic activity[d][22],iron-sulfur cluster assembly[d][7][7][19],оксидлашулы фосфориллау[d][7],cellular iron ion homeostasis[d][20][7][7][…],mitochondrion organization[d][7][16],adult walking behavior[d][7],аэробное дыхание[d][7],embryo development ending in birth or egg hatching[d][7],iron incorporation into metallo-sulfur cluster[d][13][16],проприоцепция[d][7],negative regulation of multicellular organism growth[d][7] һәмnegative regulation of organ growth[d][7]
Изображение Gene Atlas
 FXN Викиҗыентыкта

FXN (ингл. ) —аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[26][27]

Искәрмәләр

[үзгәртү |вики-текстны үзгәрт]
  1. 1,01,1UniProt
  2. Shan Y., Cortopassi G.Mitochondrial Hspa9/Mortalin regulates erythroid differentiation via iron-sulfur cluster assembly //MitochondrionElsevier, 2015. — ISSN1567-7249;1872-8278doi:10.1016/J.MITO.2015.12.005PMID:26702583
  3. Vázquez-Manrique R. P.,Sanz P.,Palau F.Frataxin interacts functionally with mitochondrial electron transport chain proteins //Human Molecular GeneticsOUP, 2005. — ISSN0964-6906;1460-2083doi:10.1093/HMG/DDI214PMID:15961414
  4. 4,04,14,24,34,4Yoon T., Cowan J. A.Frataxin-mediated iron delivery to ferrochelatase in the final step of heme biosynthesis //J. Biol. Chem. /L. M. GieraschBaltimore [etc.]:American Society for Biochemistry and Molecular Biology, 2004. — ISSN0021-9258;1083-351X;1067-8816doi:10.1074/JBC.C400107200PMID:15123683
  5. 5,05,1Yoon T., Cowan J. A.Frataxin-mediated iron delivery to ferrochelatase in the final step of heme biosynthesis //J. Biol. Chem. /L. M. GieraschBaltimore [etc.]:American Society for Biochemistry and Molecular Biology, 2004. — ISSN0021-9258;1083-351X;1067-8816doi:10.1074/JBC.C400107200PMID:15123683
  6. 6,06,16,26,3Yoon T., Cowan J. A.Iron-sulfur cluster biosynthesis. Characterization of frataxin as an iron donor for assembly of [2Fe-2S clusters in ISU-type proteins] //J. Am. Chem. Soc. /P. J. StangACS, 2003. — ISSN0002-7863;1520-5126;1943-2984doi:10.1021/JA027967IPMID:12785837
  7. 7,007,017,027,037,047,057,067,077,087,097,107,117,127,137,147,157,167,177,187,197,207,217,227,237,247,257,267,27GOA
  8. Yoon T., Dizin E., Cowan J. A.N-terminal iron-mediated self-cleavage of human frataxin: regulation of iron binding and complex formation with target proteins //Journal of Biological Inorganic ChemistrySpringer Science+Business Media, 2007. — ISSN0949-8257;1432-1327doi:10.1007/S00775-007-0205-2PMID:17285345
  9. 9,09,19,29,39,49,59,6GOA
  10. Pastore A.,Adinolfi S.,Gomes C. M.Dynamics, stability and iron-binding activity of frataxin clinical mutants //FEBS J.Wiley-Blackwell, 2008. — ISSN1742-464X;1742-4658doi:10.1111/J.1742-4658.2008.06512.XPMID:18537827
  11. Heather A O'Neill, Gakh O., Park S. et al.Assembly of human frataxin is a mechanism for detoxifying redox-active iron //BiochemistryACS, 2005. — ISSN0006-2960;1520-4995;1943-295Xdoi:10.1021/BI048459JPMID:15641778
  12. 12,012,1Heather A O'Neill, Gakh O., Park S. et al.Assembly of human frataxin is a mechanism for detoxifying redox-active iron //BiochemistryACS, 2005. — ISSN0006-2960;1520-4995;1943-295Xdoi:10.1021/BI048459JPMID:15641778
  13. 13,013,113,213,313,4Yoon T., Cowan J. A.Iron-sulfur cluster biosynthesis. Characterization of frataxin as an iron donor for assembly of [2Fe-2S clusters in ISU-type proteins] //J. Am. Chem. Soc. /P. J. StangACS, 2003. — ISSN0002-7863;1520-5126;1943-2984doi:10.1021/JA027967IPMID:12785837
  14. 14,014,1Yoon T., Dizin E., Cowan J. A.N-terminal iron-mediated self-cleavage of human frataxin: regulation of iron binding and complex formation with target proteins //Journal of Biological Inorganic ChemistrySpringer Science+Business Media, 2007. — ISSN0949-8257;1432-1327doi:10.1007/S00775-007-0205-2PMID:17285345
  15. Pastore A.,Adinolfi S.,Gomes C. M.Dynamics, stability and iron-binding activity of frataxin clinical mutants //FEBS J.Wiley-Blackwell, 2008. — ISSN1742-464X;1742-4658doi:10.1111/J.1742-4658.2008.06512.XPMID:18537827
  16. 16,016,116,216,3Livstone M. S.,Thomas P. D.,Lewis S. E. et al.Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium //Brief. Bioinform.OUP, 2011. — ISSN1467-5463;1477-4054doi:10.1093/BIB/BBR042PMID:21873635
  17. Condò I.,Ventura N.,Malisan F. et al.In vivo maturation of human frataxin //Human Molecular GeneticsOUP, 2007. — ISSN0964-6906;1460-2083doi:10.1093/HMG/DDM102PMID:17468497
  18. Condò I.,Ventura N.,Malisan F. et al.In vivo maturation of human frataxin //Human Molecular GeneticsOUP, 2007. — ISSN0964-6906;1460-2083doi:10.1093/HMG/DDM102PMID:17468497
  19. 19,019,1Missirlis F.,Leimkühler S.Iron Sulfur and Molybdenum Cofactor Enzymes Regulate the Drosophila Life Cycle by Controlling Cell Metabolism //Frontiers in PhysiologyFrontiers Media, 2018. — ISSN1664-042Xdoi:10.3389/FPHYS.2018.00050PMID:29491838
  20. 20,020,120,220,320,4Verardi R.,Cavadini P.,Zanella I. et al.The effects of frataxin silencing in HeLa cells are rescued by the expression of human mitochondrial ferritin //Biochim. Biophys. ActaElsevier, 2008. — ISSN0006-3002;1878-2434doi:10.1016/J.BBADIS.2007.11.006PMID:18160053
  21. Li K., Besse E. K., Ha D. et al.Iron-dependent regulation of frataxin expression: implications for treatment of Friedreich ataxia //Human Molecular GeneticsOUP, 2008. — ISSN0964-6906;1460-2083doi:10.1093/HMG/DDN127PMID:18424449
  22. 22,022,1Mühlenhoff U.,Lill R.Iron-sulfur protein maturation in human cells: evidence for a function of frataxin //Human Molecular GeneticsOUP, 2004. — ISSN0964-6906;1460-2083doi:10.1093/HMG/DDH324PMID:15509595
  23. 23,023,1Condò I.,Ventura N.,Malisan F. et al.A pool of extramitochondrial frataxin that promotes cell survival //J. Biol. Chem. /L. M. GieraschBaltimore [etc.]:American Society for Biochemistry and Molecular Biology, 2006. — ISSN0021-9258;1083-351X;1067-8816doi:10.1074/JBC.M511960200PMID:16608849
  24. Verardi R.,Cavadini P.,Zanella I. et al.The effects of frataxin silencing in HeLa cells are rescued by the expression of human mitochondrial ferritin //Biochim. Biophys. ActaElsevier, 2008. — ISSN0006-3002;1878-2434doi:10.1016/J.BBADIS.2007.11.006PMID:18160053
  25. Guccini I.,Condò I.,Malisan F.Molecular control of the cytosolic aconitase/IRP1 switch by extramitochondrial frataxin //Human Molecular GeneticsOUP, 2010. — ISSN0964-6906;1460-2083doi:10.1093/HMG/DDP592PMID:20053667
  26. HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланды. 18 сентябрь, 2017 тикшерелгән.
  27. UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.

Чыганаклар

[үзгәртү |вики-текстны үзгәрт]
  • Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука.ISBN 5-211-04971-3.(рус.)
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland.ISBN 0815332181.(ингл.)
Миоглобин молекуласы
Чыганак —https://tt.wikipedia.org/w/index.php?title=FXN&oldid=4128705
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