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CCR2

Wikipedia — ирекле энциклопедия проектыннан ([http://tt.wikipedia.org.ttcysuttlart1999.aylandirow.tmf.org.ru/wiki/CCR2 latin yazuında])
CCR2
Сурәт
Нинди таксонда барH. sapiens[d][1]
Кодлаучы генCCR2[d][1]
Молекуляр функцияCCR2 chemokine receptor binding[d][2],G protein-coupled receptor activity[d][3][3],гомодимеризация белка[d][3],signal transducer activity[d][4],chemokine receptor activity[d][5][3],C-C chemokine receptor activity[d][4][4],связывание с белками плазмы[d][6],cytokine binding[d][3],chemokine (C-C motif) ligand 2 binding[d][3],chemokine (C-C motif) ligand 12 binding[d][3],chemokine (C-C motif) ligand 7 binding[d][3],C-C chemokine receptor activity[d][3][3][7],chemokine binding[d][7] һәмC-C chemokine binding[d][7]
Күзәнәк компонентымембрана өлеше[d][8][3][3],перикарион[d][3],мембрана[d][3],күзәнәк мембранасы[d][3][9][3][…],күзәнәк мембранасы өлеше[d][10],soma[d][3],дендрит[d][3],perinuclear region of cytoplasm[d][3],цитоплазма[11],цитозоль[d][3],наружная сторона клеточной мембраны[d][4],цитоплазма[2][7] һәмнаружная сторона клеточной мембраны[d][3][7]
Биологик процессnegative regulation of adenylate cyclase activity[d][12],receptor signaling pathway via JAK-STAT[d][13],chemokine-mediated signaling pathway[d][3],cellular calcium ion homeostasis[d][3],positive regulation of monocyte chemotaxis[d][3][3][3][…],dendritic cell chemotaxis[d][14],хемотаксис[d][15][4],blood vessel remodeling[d][3][3],response to wounding[d][10],иммун җавап[d][16][4][4],воспалительная реакция[d][15][4][4],вирусный процесс[d][3],positive regulation of astrocyte chemotaxis[d][17],передача сигнала[d][3],positive regulation of cytosolic calcium ion concentration[d][18],G protein-coupled receptor signaling pathway[d][3][3][3],monocyte chemotaxis[d][3],positive regulation of T-helper 1 type immune response[d][3][3],negative regulation of type 2 immune response[d][3][3],humoral immune response[d][3],cellular defense response[d][19][3],regulation of vascular endothelial growth factor production[d][3][3],positive regulation of T cell chemotaxis[d][3][3],negative regulation of angiogenesis[d][3][3],ноцицепция[d][4],cellular homeostasis[d][3][3],regulation of cell migration[d][3],positive regulation of interferon-gamma production[d][3][3],positive regulation of interleukin-2 production[d][3][3],T-helper 17 cell chemotaxis[d][3][3],negative regulation of eosinophil degranulation[d][3][3],positive regulation of alpha-beta T cell proliferation[d][3][3],homeostasis of number of cells within a tissue[d][3],positive regulation of inflammatory response[d][3][3],positive regulation of T cell activation[d][3][3],leukocyte adhesion to vascular endothelial cell[d][3],positive regulation of immune complex clearance by monocytes and macrophages[d][3][3],neutrophil clearance[d][3],positive regulation of leukocyte tethering or rolling[d][3],positive regulation of monocyte extravasation[d][3][3],positive regulation of CD8-positive, alpha-beta T cell extravasation[d][3][3],positive regulation of hematopoietic stem cell migration[d][3][3],cytokine-mediated signaling pathway[d][3][2],гемопоэз[d][3],хемотаксис[d][5][3][7],воспалительная реакция[d][5][3][3][…],иммун җавап[d][20][3][3][…],positive regulation of cytosolic calcium ion concentration[d][21][7],calcium-mediated signaling[d][7],cell chemotaxis[d][7],positive regulation of cold-induced thermogenesis[d][22][3],regulation of T cell cytokine production[d][3][3],ноцицепция[d][3][3],monocyte extravasation[d][3][3],regulation of T cell differentiation[d][3][3],regulation of inflammatory response[d][3][3],positive regulation of synaptic transmission, glutamatergic[d][3][3],inflammatory response to wounding[d][3][3],macrophage migration[d][3][3],positive regulation of thymocyte migration[d][3][3] һәмpositive regulation of NMDA glutamate receptor activity[d][3]

CCR2 (ингл. ) —аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[23][24]

Искәрмәләр

[үзгәртү |вики-текстны үзгәртү]
  1. 1,01,1UniProt
  2. 2,02,12,2Terashima Y.,Kanegasaki S.Pivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxis //Nat. Immunol.USA:NPG, 2005. — ISSN1529-2908;1529-2916doi:10.1038/NI1222PMID:15995708
  3. 3,0003,0013,0023,0033,0043,0053,0063,0073,0083,0093,0103,0113,0123,0133,0143,0153,0163,0173,0183,0193,0203,0213,0223,0233,0243,0253,0263,0273,0283,0293,0303,0313,0323,0333,0343,0353,0363,0373,0383,0393,0403,0413,0423,0433,0443,0453,0463,0473,0483,0493,0503,0513,0523,0533,0543,0553,0563,0573,0583,0593,0603,0613,0623,0633,0643,0653,0663,0673,0683,0693,0703,0713,0723,0733,0743,0753,0763,0773,0783,0793,0803,0813,0823,0833,0843,0853,0863,0873,0883,0893,0903,0913,0923,0933,0943,0953,0963,0973,0983,0993,1003,101GOA
  4. 4,004,014,024,034,044,054,064,074,084,09GOA
  5. 5,05,15,2B Bottazzi,F Balkwill,A MantovaniDefective expression of the monocyte chemotactic protein-1 receptor CCR2 in macrophages associated with human ovarian carcinoma //J. Immunol.Baltimore: 2000. — ISSN0022-1767;1550-6606doi:10.4049/JIMMUNOL.164.2.733PMID:10623817
  6. Paula V. d.,Almeida F. C. L.,Valente A. P.Structural basis for the interaction of human β-defensin 6 and its putative chemokine receptor CCR2 and breast cancer microvesicles //Journal of Molecular Biology /P. WrightElsevier BV, 2013. — ISSN0022-2836;1089-8638doi:10.1016/J.JMB.2013.08.001PMID:23938203
  7. 7,07,17,27,37,47,57,67,77,8Livstone M. S.,Thomas P. D.,Lewis S. E. et al.Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium //Brief. Bioinform.OUP, 2011. — ISSN1467-5463;1477-4054doi:10.1093/BIB/BBR042PMID:21873635
  8. C Combadiere, Ahuja S. K., Damme J. V. et al.Monocyte chemoattractant protein-3 is a functional ligand for CC chemokine receptors 1 and 2B, Monocyte Chemoattractant Protein-3 Is a Functional Ligand for CC Chemokine Receptors 1 and 2B //J. Biol. Chem. /L. M. GieraschBaltimore [etc.]:American Society for Biochemistry and Molecular Biology, 1995. — 5 p. — ISSN0021-9258;1083-351X;1067-8816doi:10.1074/JBC.270.50.29671PMID:8530354
  9. Agace W. W., Roberts A. I., L Wu et al.Human intestinal lamina propria and intraepithelial lymphocytes express receptors specific for chemokines induced by inflammation //Eur. J. Immunol.Wiley-Blackwell, 2000. — ISSN0014-2980;1521-4141<819::AID-IMMU819>3.0.CO;2-Y doi:10.1002/1521-4141(200003)30:3<819::AID-IMMU819>3.0.CO;2-YPMID:10741397
  10. 10,010,1Charo I. F., Myers S. J., A Herman et al.Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails //Proc. Natl. Acad. Sci. U.S.A. /M. R. Berenbaum[Washington, etc.],USA:National Academy of Sciences [etc.], 1994. — ISSN0027-8424;1091-6490doi:10.1073/PNAS.91.7.2752PMID:8146186
  11. Terashima Y.,Kanegasaki S.Pivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxis //Nat. Immunol.USA:NPG, 2005. — ISSN1529-2908;1529-2916doi:10.1038/NI1222PMID:15995708
  12. Wong L. M., Myers S. J., Tsou C. L. et al.Organization and differential expression of the human monocyte chemoattractant protein 1 receptor gene. Evidence for the role of the carboxyl-terminal tail in receptor trafficking //J. Biol. Chem. /L. M. GieraschBaltimore [etc.]:American Society for Biochemistry and Molecular Biology, 1997. — ISSN0021-9258;1083-351X;1067-8816doi:10.1074/JBC.272.2.1038PMID:8995400
  13. A. Aragay,A. SerranoThe chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor //J. Immunol.Baltimore: 1998. — ISSN0022-1767;1550-6606PMID:9670957
  14. Rodríguez-Fernández J. L.The multiple personalities of the chemokine receptor CCR7 in dendritic cells //J. Immunol.Baltimore: 2006. — ISSN0022-1767;1550-6606doi:10.4049/JIMMUNOL.176.9.5153PMID:16621978
  15. 15,015,1B Bottazzi,F Balkwill,A MantovaniDefective expression of the monocyte chemotactic protein-1 receptor CCR2 in macrophages associated with human ovarian carcinoma //J. Immunol.Baltimore: 2000. — ISSN0022-1767;1550-6606doi:10.4049/JIMMUNOL.164.2.733PMID:10623817
  16. McManus C. M., K Weidenheim, Woodman S. E. et al.Chemokine and chemokine-receptor expression in human glial elements: induction by the HIV protein, Tat, and chemokine autoregulation //Am. J. Pathol.Elsevier BV, 2000. — ISSN0002-9440;1525-2191;0097-3599doi:10.1016/S0002-9440(10)65013-4PMID:10751368
  17. Andjelkovic A. V., Song L., Dzenko K. A. et al.Functional expression of CCR2 by human fetal astrocytes //J. Neurosci. Res.Wiley, 2002. — ISSN0360-4012;1097-4547doi:10.1002/JNR.10372PMID:12271471
  18. Frade J. M., M. Mellado, G. del Real et al.Characterization of the CCR2 chemokine receptor: functional CCR2 receptor expression in B cells //J. Immunol.Baltimore: 1997. — ISSN0022-1767;1550-6606PMID:9548499
  19. Rabin R. L., Park M. K., F Liao et al.Chemokine receptor responses on T cells are achieved through regulation of both receptor expression and signaling //J. Immunol.Baltimore: 1999. — ISSN0022-1767;1550-6606PMID:10201901
  20. McManus C. M., K Weidenheim, Woodman S. E. et al.Chemokine and chemokine-receptor expression in human glial elements: induction by the HIV protein, Tat, and chemokine autoregulation //Am. J. Pathol.Elsevier BV, 2000. — ISSN0002-9440;1525-2191;0097-3599doi:10.1016/S0002-9440(10)65013-4PMID:10751368
  21. Frade J. M., M. Mellado, G. del Real et al.Characterization of the CCR2 chemokine receptor: functional CCR2 receptor expression in B cells //J. Immunol.Baltimore: 1997. — ISSN0022-1767;1550-6606PMID:9548499
  22. Qiu Y.,Tian X. Y.,Locksley R. M.Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat //CellCell Press,Elsevier BV, 2014. — ISSN0092-8674;1097-4172doi:10.1016/J.CELL.2014.03.066PMID:24906148
  23. HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланды. 18 сентябрь, 2017 тикшерелгән.
  24. UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.

Чыганаклар

[үзгәртү |вики-текстны үзгәртү]
  • Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука.ISBN 5-211-04971-3.(рус.)
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland.ISBN 0815332181.(ингл.)


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