Related Resources
The BioGRID Open Respository of CRISPR Screens (ORCS) is a publicly accessibledatabase of CRISPR screens compiled through comprehensive curation of all genome-wide CRISPR screen data reported in the biomedical literature. ORCS is updated on a quarterly basis and is fully searchable by gene/protein, phenotype, cell line, authors, and other attributes. Each screen recorded in ORCS is accompanied by structured metadata annotation that captures salient CRISPR experimental details. All data in ORCS can be downloaded in standard formats.
BioGRID themed curation projects focus on specific biological processes with disease relevance. Core genes/proteins central to the process are assembled with expert input and relevant publications curated for biological interactions. Themed curation projects are updated monthly and additional projects are generated on a regular basis.
Seecurrent projects onSynthetic Protein Interaction Project,Human Papilloma Virus (HPV),Autism spectrum disorder,Alzheimer's Disease,COVID-19 Coronavirus,Fanconi Anemia,Glioblastoma,the Yeast Kinome,the Ubiquitin-Proteasome System andAutophagy. If you would like to suggest or participate in a new themed project, please contactsupport@thebiogrid.org
GIX is a browser extension that allows you to retrieve information about a gene product directly on any webpage simply by double clicking an official gene name, synonym or supported accession.
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Latest News
TheBioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from86,536 publications. These additions bring our total number of non-redundant interactions to2,203,605, raw interactions to2,840,984, non-redundant chemical associations to13,719, raw chemical associations to31,144, Non-Redundant PTM Sites to563,757 and Un-Assigned PTMs to57,396.
New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our lateststatistics. To download these data, visit ourdownload page or utilize ourweb service.
Posted: April 1, 2025 - 12:28 am
TheBioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from86,477 publications. These additions bring our total number of non-redundant interactions to2,201,055, raw interactions to2,837,675, non-redundant chemical associations to13,719, raw chemical associations to31,144, Non-Redundant PTM Sites to563,757 and Un-Assigned PTMs to57,396.
New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our lateststatistics. To download these data, visit ourdownload page or utilize ourweb service.
Posted: March 3, 2025 - 1:12 am
TheBioGRID ORCS curated CRISPR database has been updated to include CRISPR screens from a total of382 different publications. These additions bring the total number of curated CRISPR screens in our database to2,134 encompassing93,295 genes,809 different cell lines,137 different cell types, and29 different phenotypes across5 different organisms (Budding Yeast, Human, Mouse, African Green Monkey, and Fruit Fly).
New curated data are added to ourCRISPR Database in curation updates on a regular basis. For a more comprehensive breakdown of our numbers, check out our lateststatistics. To download these CRISPR data, visit ourdownload page or utilize ourweb service.
Posted: February 1, 2025 - 10:11 pm
TheBioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from86,339 publications. These additions bring our total number of non-redundant interactions to2,199,035, raw interactions to2,834,410, non-redundant chemical associations to13,719, raw chemical associations to31,144, Non-Redundant PTM Sites to563,757 and Un-Assigned PTMs to57,396.
New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our lateststatistics. To download these data, visit ourdownload page or utilize ourweb service.
Posted: February 1, 2025 - 12:20 am
TheBioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from86,161 publications. These additions bring our total number of non-redundant interactions to2,194,102, raw interactions to2,826,897, non-redundant chemical associations to13,719, raw chemical associations to31,144, Non-Redundant PTM Sites to563,757 and Un-Assigned PTMs to57,396.
New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our lateststatistics. To download these data, visit ourdownload page or utilize ourweb service.
Posted: January 1, 2025 - 12:22 am
TheBioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from86,032 publications. These additions bring our total number of non-redundant interactions to2,192,664, raw interactions to2,824,633, non-redundant chemical associations to13,719, raw chemical associations to31,144, Non-Redundant PTM Sites to563,757 and Un-Assigned PTMs to57,396.
New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our lateststatistics. To download these data, visit ourdownload page or utilize ourweb service.
Posted: December 1, 2024 - 10:12 am
TheBioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from85,855 publications. These additions bring our total number of non-redundant interactions to2,189,120, raw interactions to2,818,695, non-redundant chemical associations to13,719, raw chemical associations to31,144, Non-Redundant PTM Sites to563,757 and Un-Assigned PTMs to57,396.
New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our lateststatistics. To download these data, visit ourdownload page or utilize ourweb service.
Posted: November 1, 2024 - 1:43 pm
TheBioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from85,657 publications. These additions bring our total number of non-redundant interactions to2,181,625, raw interactions to2,807,416, non-redundant chemical associations to13,719, raw chemical associations to31,144, Non-Redundant PTM Sites to563,757 and Un-Assigned PTMs to57,396.
New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our lateststatistics. To download these data, visit ourdownload page or utilize ourweb service.
Posted: October 1, 2024 - 3:23 pm
TheBioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from85,467 publications. These additions bring our total number of non-redundant interactions to2,176,165, raw interactions to2,800,228, non-redundant chemical associations to13,719, raw chemical associations to31,144, Non-Redundant PTM Sites to563,757 and Un-Assigned PTMs to57,396.
New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our lateststatistics. To download these data, visit ourdownload page or utilize ourweb service.
Posted: September 1, 2024 - 10:35 am
TheBioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from85,299 publications. These additions bring our total number of non-redundant interactions to2,171,000, raw interactions to2,793,287, non-redundant chemical associations to13,719, raw chemical associations to31,144, Non-Redundant PTM Sites to563,757 and Un-Assigned PTMs to57,396.
New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our lateststatistics. To download these data, visit ourdownload page or utilize ourweb service.
Posted: August 1, 2024 - 8:14 am
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