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Timopoietin

Уреди везе

С Википедије, слободне енциклопедије

Timopoietin

PDB prikaz baziran na1gjj.

Dostupne strukture

1GJJ,1H9E,1H9F

Identifikatori

Simboli

TMPO; CMD1T; LAP2; LEMD4; PRO0868; TP

Vanjski ID

OMIM: 188380MGI: 106920HomoloGene: 31144GeneCards:TMPO Gene

Ontologija gena
Molekularna funkcija	•DNK vezivanje •proteinsko vezivanje •laminsko vezivanje
Celularna komponenta	•hromatin •jedro •unutrašnja membrana jedra
Biološki proces	•regulacija transkripcije, DNK-zavisna

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

RefSeq (mRNA)

RefSeq (protein)

Lokacija (UCSC)

Chr 12:
98.91 - 98.94 Mb

Chr 10:
91.15 - 91.17 Mb

PubMed pretraga

[1]

[2]

Timopoietin (polipeptid vezan za laminu 2,LAP2) jeprotein koji je kod ljudi kodiranTMPOgenom.^[1]^[2] LAP2 jeprotein unutrašnje membrane jedra.^[3]

Timopoietin učestvuje u indukcijiCD90 proteina ugrudnu žlezdu. Gen timopoetina kodira trialternativno splajsovane iRNK molekula koji kodiraju proteine sa 75 kDa (alfa), 51 kDa (beta) i 39 kDa (gama). Oni su izraženi u većini ćelijskih tipova. Ljudski TMPO gen se nalazi u hromozomsko opsegu 12q22 i sastoji se od osameksona.

Interakcije

[уреди |уреди извор]

Timopoietin formirainterakcije sabarijerom za autointegracioni faktor 1,^[4]AKAP8L,^[5]^[6]LMNB1^[7]^[8] iLMNA.^[9]^[10]

Reference

[уреди |уреди извор]

^Harris CA, Andryuk PJ, Cline S, Chan HK, Natarajan A, Siekierka JJ, Goldstein G (1994).„Three distinct human thymopoietins are derived from alternatively spliced mRNAs”.Proc Natl Acad Sci U S A.91 (14): 6283—7.PMC 44185 .PMID 7517549.doi:10.1073/pnas.91.14.6283.
^„Entrez Gene: TMPO thymopoietin”.
^„Inner nuclear membrane proteins: functions and targeting”.PMID 11766875.
^Furukawa, K (1999). „LAP2 binding protein 1 (L2BP1/BAF) is a candidate mediator of LAP2-chromatin interaction”.J. Cell. Sci. ENGLAND.112 (15): 2485—92.ISSN 0021-9533.PMID 10393804.
^Martins, S B; T, Eide; et al. (2000). „HA95 is a protein of the chromatin and nuclear matrix regulating nuclear envelope dynamics”.J. Cell. Sci. ENGLAND.113 (21): 3703—13.ISSN 0021-9533.PMID 11034899.
^Martins, Sandra; Sissel, Eikvar; et al. (2003).„HA95 and LAP2 beta mediate a novel chromatin-nuclear envelope interaction implicated in initiation of DNA replication”.J. Cell Biol. United States.160 (2): 177—88.ISSN 0021-9525.PMC 2172640 .PMID 12538639.doi:10.1083/jcb.200210026.
^Furukawa, K; T, Kondo (1998). „Identification of the lamina-associated-polypeptide-2-binding domain of B-type lamin”.Eur. J. Biochem. GERMANY.251 (3): 729—33.ISSN 0014-2956.PMID 9490046.doi:10.1046/j.1432-1327.1998.2510729.x.
^Foisner, R; L, Gerace (1993). „Integral membrane proteins of the nuclear envelope interact with lamins and chromosomes, and binding is modulated by mitotic phosphorylation”.Cell. UNITED STATES.73 (7): 1267—79.ISSN 0092-8674.PMID 8324822.doi:10.1016/0092-8674(93)90355-T.
^Markiewicz, Ewa; Thomas, Dechat; et al. (2002).„Lamin A/C binding protein LAP2alpha is required for nuclear anchorage of retinoblastoma protein”.Mol. Biol. Cell. United States.13 (12): 4401—13.ISSN 1059-1524.PMC 138642 .PMID 12475961.doi:10.1091/mbc.E02-07-0450.
^Dechat, T; B, Korbei; et al. (2000). „Lamina-associated polypeptide 2alpha binds intranuclear A-type lamins”.J. Cell. Sci. ENGLAND.113 (19): 3473—84.ISSN 0021-9533.PMID 10984438.

Literatura

[уреди |уреди извор]

Harris CA, Andryuk PJ, Cline SW, Mathew S, Siekierka JJ, Goldstein G (1995). „Structure and mapping of the human thymopoietin (TMPO) gene and relationship of human TMPO beta to rat lamin-associated polypeptide 2”.Genomics.28 (2): 198—205.PMID 8530026.doi:10.1006/geno.1995.1131.
Dechat T, Vlcek S, Foisner R (2000). „Review: lamina-associated polypeptide 2 isoforms and related proteins in cell cycle-dependent nuclear structure dynamics.”.J. Struct. Biol.129 (2-3): 335—45.PMID 10806084.doi:10.1006/jsbi.2000.4212.
JJ, Twomey; G, Goldstein; VM, Lewis; et al. (1977).„Bioassay determinations of thymopoietin and thymic hormone levels in human plasma.”.Proc. Natl. Acad. Sci. U.S.A.74 (6): 2541—5.PMC 432209 .PMID 302007.doi:10.1073/pnas.74.6.2541.
Heavner GA, Audhya T, Goldstein G (1990). „Peptide analogs of thymopentin distinguish distinct thymopoietin receptor specificities on two human T cell lines.”.Regul. Pept.27 (2): 257—62.PMID 2158125.doi:10.1016/0167-0115(90)90044-W.
Fuccello A, Audhya T, Talle MA, Goldstein G (1984). „Immunoassay for bovine serum thymopoietin: discrimination from splenin by monoclonal antibodies.”.Arch. Biochem. Biophys.228 (1): 292—8.PMID 6364989.doi:10.1016/0003-9861(84)90070-5.
H, Hara; K, Hayashi; K, Ohta; et al. (1995). „A new thymopoietin precursor gene from human thymus.”.Biochem. Mol. Biol. Int.34 (5): 927—33.PMID 7703909.
Goldstein G, Schlesinger DH, Audhya T (1994).„Isolation and complete amino acid sequence of human thymopoietin and splenin.”.Proc. Natl. Acad. Sci. U.S.A.91 (13): 6249.PMC 44176 .PMID 8016147.doi:10.1073/pnas.91.13.6249.
CA, Harris; PJ, Andryuk; SW, Cline; et al. (1996). „Structure and mapping of the human thymopoietin (TMPO) gene and relationship of human TMPO beta to rat lamin-associated polypeptide 2.”.Genomics.28 (2): 198—205.PMID 8530026.doi:10.1006/geno.1995.1131.
B, Andersson; MA, Wentland; JY, Ricafrente; et al. (1996). „A "double adaptor" method for improved shotgun library construction.”.Anal. Biochem.236 (1): 107—13.PMID 8619474.doi:10.1006/abio.1996.0138.
R, Berger; L, Theodor; J, Shoham; et al. (1996). „The characterization and localization of the mouse thymopoietin/lamina-associated polypeptide 2 gene and its alternatively spliced products.”.Genome Res.6 (5): 361—70.PMID 8743987.doi:10.1101/gr.6.5.361.
W, Yu; B, Andersson; KC, Worley; et al. (1997).„Large-scale concatenation cDNA sequencing.”.Genome Res.7 (4): 353—8.PMC 139146 .PMID 9110174.doi:10.1101/gr.7.4.353.
Furukawa K, Fritze CE, Gerace L (1998). „The major nuclear envelope targeting domain of LAP2 coincides with its lamin binding region but is distinct from its chromatin interaction domain.”.J. Biol. Chem.273 (7): 4213—9.PMID 9461618.doi:10.1074/jbc.273.7.4213.
Furukawa K, Kondo T (1998). „Identification of the lamina-associated-polypeptide-2-binding domain of B-type lamin.”.Eur. J. Biochem.251 (3): 729—33.PMID 9490046.doi:10.1046/j.1432-1327.1998.2510729.x.
T, Dechat; J, Gotzmann; A, Stockinger; et al. (1998).„Detergent-salt resistance of LAP2alpha in interphase nuclei and phosphorylation-dependent association with chromosomes early in nuclear assembly implies functions in nuclear structure dynamics.”.EMBO J.17 (16): 4887—902.PMC 1170818 .PMID 9707448.doi:10.1093/emboj/17.16.4887.
K, Furukawa (1999). „LAP2 binding protein 1 (L2BP1/BAF) is a candidate mediator of LAP2-chromatin interaction.”.J. Cell. Sci.112 (15): 2485—92.PMID 10393804.
PJ, Weber; CP, Eckhard; S, Gonser; et al. (1999).„On the role of thymopoietins in cell proliferation. Immunochemical evidence for new members of the human thymopoietin family.”.Biol. Chem.380 (6): 653—60.PMID 10430029.doi:10.1515/BC.1999.081.
T, Dechat; B, Korbei; OA, Vaughan; et al. (2000). „Lamina-associated polypeptide 2alpha binds intranuclear A-type lamins.”.J. Cell. Sci.113 (19): 3473—84.PMID 10984438.
SB, Martins; T, Eide; RL, Steen; et al. (2001). „HA95 is a protein of the chromatin and nuclear matrix regulating nuclear envelope dynamics.”.J. Cell. Sci.113 (21): 3703—13.PMID 11034899.

Spoljašnje veze

[уреди |уреди извор]

Thymopoietins наUS National Library of Medicine Medical Subject Headings (MeSH)

п р у PDB Galerija
1gjj: N-terminalni konstantni region proteina omotača jedra LAP2 1h9e: Domen sličan LEM-u ljudskog proteina unutrašnje membrane jedra LAP2 1h9f: LEM domen ljudskog proteina unutrašnje membrane jedra LAP2

Endokrini sistem:hormoni (Peptidni hormoni · Steroidni hormoni)

Endokrine
žlezde

Hipotalamusno-
hipofizni

Hipotalamus	GnRH · TRH · Dopamin · CRH · GHRH/Somatostatin · Melanin-koncentrirajući hormon
Posteriorno hipofizni	Vazopresin · Oksitocin
Anteriorno hipfizni	α (FSH FSHB,LH LHB,TSH TSHB,CGA) · Prolaktin · POMC (CLIP,ACTH,MSH,Endorfini,Lipotropin) · GH