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S1PR1

Уреди везе

С Википедије, слободне енциклопедије

Sfingozin-1-fosfatni receptor 1

Struktura SIPR1-lizozim fuzije3v2y^[1]

Dostupne strukture

3V2W,3V2Y

Identifikatori

Simboli

S1PR1; CD363; CHEDG1; D1S3362; ECGF1; EDG-1; EDG1; S1P1

Vanjski ID

OMIM: 601974MGI: 1096355HomoloGene: 1071IUPHAR:S₁P₁GeneCards:S1PR1 Gene

Ontologija gena
Molekularna funkcija	•aktivnost G-protein spregnutog receptora •aktivnost sfingozin-1-fosfat receptora •vezivanje sfingolipida
Celularna komponenta	•ćelijska membrana •spoljašnja strana ćelijske membrane •integralno sa membranom
Biološki proces	•angiogeneza •ćelijska adhezija •signalni put G-protein spregnutog receptora

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

RefSeq (mRNA)

RefSeq (protein)

Lokacija (UCSC)

Chr 1:
101.7 - 101.71 Mb

Chr 3:
115.41 - 115.42 Mb

PubMed pretraga

[1]

[2]

S1PR1 (sfingozin-1-fosfatni receptor 1,S1P₁,EDG1, endotelni diferencijacioni gen 1) jeprotein koji je kod ljudi kodiranS1PR1genom. S1P₁ jeG protein spregnuti receptor za koji se vezuje lipidni signalni molekulsfingozin-1-fosfat (S1P).

Funkcija

[уреди |уреди извор]

Ovaj protein je visoko izražen uendotelnim ćelijama. On vezuje sfingozin-1-fosfat sa visokim afinitetom i specifičnošću, i smatra se da učestvuje u procesima koji regulišu diferencijaciju endotelnih ćelija. Aktivacija ovog receptora indukuje međućelijskuadheziju.^[2]

Interakcije

[уреди |уреди извор]

S1PR1 formirainterakcije sa5-HT1A receptorom,^[3]GNAI1^[4] iGNAI3.^[4]

Vidi još

[уреди |уреди извор]

Lizofosfolipidni receptor

Reference

[уреди |уреди извор]

^Hanson, M. A.; Roth, C. B.; Jo, E.; Griffith, M. T.; Scott, F. L.; Reinhart, G.; Desale, H.; Clemons, B.; Cahalan, S. M. (2012). „Crystal Structure of a Lipid G Protein-Coupled Receptor”.Science.335 (6070): 851.doi:10.1126/science.1215904.
^„Entrez Gene: EDG1 endothelial differentiation, sphingolipid G-protein-coupled receptor, 1”.
^Salim, Kamran; Fenton Tim; et al. (2002). „Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation”.J. Biol. Chem. United States.277 (18): 15482—5.ISSN 0021-9258.PMID 11854302.doi:10.1074/jbc.M201539200.
^^а ^бLee, M J; Evans M; Hla T (1996). „The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway”.J. Biol. Chem. UNITED STATES.271 (19): 11272—9.ISSN 0021-9258.PMID 8626678.doi:10.1074/jbc.271.19.11272.

Literatura

[уреди |уреди извор]

Spiegel S (2000). „Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors.”.Ann. N. Y. Acad. Sci.905: 54—60.PMID 10818441.doi:10.1111/j.1749-6632.2000.tb06537.x.
Igarashi Y (2002). „[Current studies on a novel lipid mediator, sphingosine 1-phosphate, and its receptors]”.Tanpakushitsu Kakusan Koso.47 (4 Suppl): 476—9.PMID 11915345.
Takuwa Y (2002). „[Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors]”.Tanpakushitsu Kakusan Koso.47 (4 Suppl): 496—502.PMID 11915348.
Takuwa Y, Takuwa N, Sugimoto N (2003). „The Edg family G protein-coupled receptors for lysophospholipids: their signaling properties and biological activities.”.J. Biochem.131 (6): 767—71.PMID 12038970.
Wang D; Zhao Z; Caperell-Grant A; et al. (2008). „S1P differentially regulates migration of human ovarian cancer and human ovarian surface epithelial cells.”.Mol Cancer Ther.7 (7): 1993—2002.PMID 18645009.
Hla T, Maciag T (1990). „An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors.”.J. Biol. Chem.265 (16): 9308—13.PMID 2160972.
Lee MJ, Evans M, Hla T (1996). „The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway.”.J. Biol. Chem.271 (19): 11272—9.PMID 8626678.doi:10.1074/jbc.271.19.11272.
Bonaldo MF, Lennon G, Soares MB (1997). „Normalization and subtraction: two approaches to facilitate gene discovery.”.Genome Res.6 (9): 791—806.PMID 8889548.doi:10.1101/gr.6.9.791.
An S; Bleu T; Huang W; et al. (1998). „Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids.”.FEBS Lett.417 (3): 279—82.PMID 9409733.doi:10.1016/S0014-5793(97)01301-X.
Lee MJ; Van Brocklyn JR; Thangada S; et al. (1998). „Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1.”.Science.279 (5356): 1552—5.PMID 9488656.doi:10.1126/science.279.5356.1552.
Lee MJ; Thangada S; Liu CH; et al. (1998). „Lysophosphatidic acid stimulates the G-protein-coupled receptor EDG-1 as a low affinity agonist.”.J. Biol. Chem.273 (34): 22105—12.PMID 9705355.doi:10.1074/jbc.273.34.22105.
Ancellin N, Hla T (1999). „Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5.”.J. Biol. Chem.274 (27): 18997—9002.PMID 10383399.doi:10.1074/jbc.274.27.18997.
Windh RT; Lee MJ; Hla T; et al. (1999). „Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins.”.J. Biol. Chem.274 (39): 27351—8.PMID 10488065.doi:10.1074/jbc.274.39.27351.
Lee MJ; Thangada S; Claffey KP; et al. (1999). „Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate.”.Cell.99 (3): 301—12.PMID 10555146.doi:10.1016/S0092-8674(00)81661-X.
Igarashi J, Michel T (2000). „Agonist-modulated targeting of the EDG-1 receptor to plasmalemmal caveolae. eNOS activation by sphingosine 1-phosphate and the role of caveolin-1 in sphingolipid signal transduction.”.J. Biol. Chem.275 (41): 32363—70.PMID 10921915.doi:10.1074/jbc.M003075200.
Parrill AL; Wang D; Bautista DL; et al. (2001). „Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate.”.J. Biol. Chem.275 (50): 39379—84.PMID 10982820.doi:10.1074/jbc.M007680200.
Liu Y; Wada R; Yamashita T; et al. (2000).„Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation.”.J. Clin. Invest.106 (8): 951—61.PMC 314347 .PMID 11032855.doi:10.1172/JCI10905.
Murphy WJ; Eizirik E; Johnson WE; et al. (2001). „Molecular phylogenetics and the origins of placental mammals.”.Nature.409 (6820): 614—8.PMID 11214319.doi:10.1038/35054550.
Hobson JP; Rosenfeldt HM; Barak LS; et al. (2001). „Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility.”.Science.291 (5509): 1800—3.PMID 11230698.doi:10.1126/science.1057559.
Lee MJ; Thangada S; Paik JH; et al. (2001). „Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis.”.Mol. Cell.8 (3): 693—704.PMID 11583630.doi:10.1016/S1097-2765(01)00324-0.

Spoljašnje veze

[уреди |уреди извор]

„Lysophospholipid Receptors: S₁P₁”.IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано изоригинала 07. 01. 2015. г.
Lysophospholipid+receptors наUS National Library of Medicine Medical Subject Headings (MeSH)

Transmembranski receptor:receptori spregnuti s G proteinom

Klasa A:Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A,B,D) • α2 (A,B,C) • β1 • β2 • β3
Purinski	Adenozinski (A1,A2A,A2B,A3) • P2Y (1,2,4,5,6,8,9,10,11,12,13,14)
Serotoninski	(svi osim 5-HT3)5-HT1 (A,B,D,E,F) • 5-HT2 (A,B,C) • 5-HT (4,5A,6,7)
Drugi	Acetilholin (M1,M2,M3,M4,M5) • Dopamin (D1,D2,D3,D4,D5) • Histamin (H1,H2,H3,H4) • Melatonin (1A,1B,1C) • TAAR (1,2,3,5,6,8,9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1,2) • LTB4 (1,2) • FPRL1 • OXE • Prostaglandin (DP (1,2),EP (1,2,3,4),FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1,CB2,GPR (18,55,119)) • EBI2 • Estrogen • Slobodna masna kiselina (1,2,3,4) • Laktat • Lizofosfatidna kiselina (1,2,3,4,5,6) • Lizofosfolipid (1,2,3,4,5,6,7,8) • Niacin (1,2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1,2,3,4,5) • Sukcinat

Peptid

Neuropeptidni

B/W (1,2) • FF (1,2) • S • Y (1,2,4,5) • Neuromedin (B,U (1,2)) • Neurotenzin (1,2)

Drugi

Anafilatoksin (C3a,C5a) • Angiotenzin (1,2) • Apelin • Bombezin (BRS3,GRPR,NMBR) • Bradikinin (B1,B2) • Hemokin • Holecistokinin (A,B) • Endotelin (A,B) • Formil peptid (1,2,3) • FSH • Galanin (1,2,3) • GHB receptor • Gonadotropin-oslobađajući hormon (1,2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1,1L,D,E,F,G,X1,X2,X3,X4) • Melanokortin (1,2,3,4,5) • MCHR (1,2) • Motilin • Opioidni (δ,κ,μ,Nociceptin &ζ, ali neσ) • Oreksin (1,2) • Oksitocin • Prokineticin (1,2) • Prolaktin-oslobađajući peptid • Relaksin (1,2,3,4) • Somatostatin (1,2,3,4,5) • Tahikinin (1,2,3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A,1B,2)

Razno

Orfan	GPR (1,3,4,6,12,15,17,18,19,20,21,22,23,25,26,27,31,32,33,34,35,37,39,42,44,45,50,52,55,61,62,63,65,68,75,77,78,81,82,83,84,85,87,88,92,101,103,109A,109B,119,120,132,135,137B,139,141,142,146,148,149,150,151,152,153,160,161,162,171,173,174,176,177,182,183)
Drugi	Adrenomedulin • Mirisni • Opsin (3,4,5,1LW,1MW,1SW,RGR,RRH) • Proteazom-aktivirani (1,2,3,4) • SREB (1,2,3)

Klasa B:Sekretinu slični

Orfan	GPR (56,64,97,98,110,111,112,113,114,115,116,123,124,125,126,128,133,143,144,155,157)
Drugi	Moždano specifični angiogenezni inhibitor (1,2,3) • Kadherin (1,2,3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1,2) • EMR (1,2,3) • Glukagon (GR,GIPR,GLP1R,GLP2R) • Hormon rasta • PACAPR1 • GPR • Latrofilin (1,2,3,ELTD1) • Metuzalemski protein • Paratiroidni hormon (1,2) • Sekretin • Vazoaktivni intestinalni peptid (1,2)

Klasa C:Metabotropni
glutamat /feromon

Ukus	TAS1R (1,2,3) • TAS2R (1,3,4,5,8,9,10,12,13,14,16,19,20,30,31,38,39,40,41,42,43,45,46,50)
Drugi	Kalcijum-detektujući receptor • GABA B (1,2) • Glutamatni receptor (Metabotropni glutamat (1,2,3,4,5,6,7,8)) • GPRC6A • GPR (156,158,179) • RAIG (1,2,3,4) • VNR (1,2,3,5)

Klasa F:
Frizzled /Zaglađeni

Uvojiti	Frizzled (1,2,3,4,5,6,7,8,9,10)
Zaglađeni	Zaglađeni

Преузето из „https://sr.wikipedia.org/w/index.php?title=S1PR1&oldid=29233878”

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