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Receptor paratiroidnog hormona

С Википедије, слободне енциклопедије

Receptor paratiroidnog hormona 1
Identifikatori
Simbol	PTH1R
Alt. simboli	PTHR
Entrez	5745
HUGO	9608
OMIM	168468
RefSeq	NM_000316
UniProt	Q03431
Ostali podaci
Lokus	Hromozom 3p22-p21.1

Receptor paratiroidnog hormona 2
Identifikatori
Simbol	PTH2R
Entrez	5746
HUGO	9609
OMIM	601469
RefSeq	NM_005048
UniProt	P49190
Ostali podaci
Lokus	Hromozom 2q33

Postoje dvareceptora paratiroidnog hormona kodsisara: PTH1R i PTH2R. Za overeceptore se vezujeparatiroidni hormon. Oni su članoviGPCR familije transmembranskihproteina.^[1]

^Jüppner H (1994). „Molecular cloning and characterization of a parathyroid hormone/parathyroid hormone-related peptide receptor: a member of an ancient family of G protein-coupled receptors”.Curr. Opin. Nephrol. Hypertens.3 (4): 371—8.PMID 8076140.doi:10.1097/00041552-199407000-00002.
^Mannstadt M, Jüppner H, Gardella TJ (1999).„Receptors for PTH and PTHrP: their biological importance and functional properties”.Am. J. Physiol.277 (5 Pt 2): F665—75.PMID 10564229. Архивирано изоригинала 13. 02. 2009. г. Приступљено04. 08. 2012.
^Offermanns S, Iida-Klein A, Segre GV, Simon MI (1996). „G alpha q family members couple parathyroid hormone (PTH)/PTH-related peptide and calcitonin receptors to phospholipase C in COS-7 cells”.Mol. Endocrinol.10 (5): 566—74.PMID 8732687.doi:10.1210/me.10.5.566.
^Usdin TB, Bonner TI, Hoare SR (2002). „The parathyroid hormone 2 (PTH2) receptor”.Recept. Channels.8 (3–4): 211—8.PMID 12529938.doi:10.1080/10606820213682.

Parathyroid+Hormone+Receptors наUS National Library of Medicine Medical Subject Headings (MeSH)
„Parathyroid Hormone Receptors”.IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано изоригинала 03. 03. 2016. г.

Adrenergički	α1 (A,B,D) • α2 (A,B,C) • β1 • β2 • β3
Purinski	Adenozinski (A1,A2A,A2B,A3) • P2Y (1,2,4,5,6,8,9,10,11,12,13,14)
Serotoninski	(svi osim 5-HT3)5-HT1 (A,B,D,E,F) • 5-HT2 (A,B,C) • 5-HT (4,5A,6,7)
Drugi	Acetilholin (M1,M2,M3,M4,M5) • Dopamin (D1,D2,D3,D4,D5) • Histamin (H1,H2,H3,H4) • Melatonin (1A,1B,1C) • TAAR (1,2,3,5,6,8,9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1,2) • LTB4 (1,2) • FPRL1 • OXE • Prostaglandin (DP (1,2),EP (1,2,3,4),FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1,CB2,GPR (18,55,119)) • EBI2 • Estrogen • Slobodna masna kiselina (1,2,3,4) • Laktat • Lizofosfatidna kiselina (1,2,3,4,5,6) • Lizofosfolipid (1,2,3,4,5,6,7,8) • Niacin (1,2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1,2,3,4,5) • Sukcinat

Peptid

B/W (1,2) • FF (1,2) • S • Y (1,2,4,5) • Neuromedin (B,U (1,2)) • Neurotenzin (1,2)

Drugi

Razno

Orfan	GPR (1,3,4,6,12,15,17,18,19,20,21,22,23,25,26,27,31,32,33,34,35,37,39,42,44,45,50,52,55,61,62,63,65,68,75,77,78,81,82,83,84,85,87,88,92,101,103,109A,109B,119,120,132,135,137B,139,141,142,146,148,149,150,151,152,153,160,161,162,171,173,174,176,177,182,183)
Drugi	Adrenomedulin • Mirisni • Opsin (3,4,5,1LW,1MW,1SW,RGR,RRH) • Proteazom-aktivirani (1,2,3,4) • SREB (1,2,3)

Orfan	GPR (56,64,97,98,110,111,112,113,114,115,116,123,124,125,126,128,133,143,144,155,157)
Drugi	Moždano specifični angiogenezni inhibitor (1,2,3) • Kadherin (1,2,3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1,2) • EMR (1,2,3) • Glukagon (GR,GIPR,GLP1R,GLP2R) • Hormon rasta • PACAPR1 • GPR • Latrofilin (1,2,3,ELTD1) • Metuzalemski protein • Paratiroidni hormon (1,2) • Sekretin • Vazoaktivni intestinalni peptid (1,2)

Ukus	TAS1R (1,2,3) • TAS2R (1,3,4,5,8,9,10,12,13,14,16,19,20,30,31,38,39,40,41,42,43,45,46,50)
Drugi	Kalcijum-detektujući receptor • GABA B (1,2) • Glutamatni receptor (Metabotropni glutamat (1,2,3,4,5,6,7,8)) • GPRC6A • GPR (156,158,179) • RAIG (1,2,3,4) • VNR (1,2,3,5)

Uvojiti	Frizzled (1,2,3,4,5,6,7,8,9,10)
Zaglađeni	Zaglađeni

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