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PRRP

Уреди везе

С Википедије, слободне енциклопедије

Prolaktin-oslobađajući hormonski receptor

Identifikatori

Simboli

PRLHR; GPR10; GR3; MGC126539; MGC126541; PrRPR

Vanjski ID

OMIM: 600895MGI: 2135956HomoloGene: 3134IUPHAR:PRRPGeneCards:PRLHR Gene

Ontologija gena
Molekularna funkcija	•aktivnost rodopsinu-sličnog receptora •receptorska aktivnost •aktivnost neuropeptid Y receptora
Celularna komponenta	•integralno sa ćelijskom membranom •membrana
Biološki proces	•prenos signala •signalni put G-protein spregnutog receptora •trudnoća •način ishrane •hormonski metabolički proces

Ortolozi

Vrsta

Čovek

Miš

RefSeq (mRNA)

RefSeq (protein)

Lokacija (UCSC)

Chr 10:
120.34 - 120.34 Mb

Chr 19:
60.52 - 60.52 Mb

PubMed pretraga

[1]

[2]

PRRP,prolaktin-oslobađajući hormonski receptor, jeG-protein spregnuti receptor^[1] koji vezujeprolaktin oslobađajući hormon.^[2]

PRLHR je 7-transmembranski receptor za prolaktin-oslobađajućihormon (PRLH; MIM 602663). On je visoko izražen u prednjojhipofizi.^[3]^[4]

Literatura

[уреди |уреди извор]

^Marchese A, Heiber M, Nguyen T, Heng HH, Saldivia VR, Cheng R, Murphy PM, Tsui LC, Shi X, Gregor P (1995). „Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors”.Genomics.29 (2): 335—44.PMID 8666380.doi:10.1006/geno.1995.9996.
^Hinuma S, Habata Y, Fujii R, Kawamata Y, Hosoya M, Fukusumi S, Kitada C, Masuo Y, Asano T, Matsumoto H, Sekiguchi M, Kurokawa T, Nishimura O, Onda H, Fujino M (1998). „A prolactin-releasing peptide in the brain”.Nature.393 (6682): 272—6.PMID 9607765.doi:10.1038/30515.
^Ozawa A; Yamada M; Satoh T; et al. (2002). „Transcriptional regulation of the human PRL-releasing peptide (PrRP) receptor gene by a dopamine 2 Receptor agonist: cloning and characterization of the human PrRP receptor gene and its promoter region”.Molecular Endocrinology (Baltimore, Md.).16 (4): 785—98.PMID 11923475. |access-date= захтева|url= (помоћ)CS1 одржавање: Експлицитна употреба et al. (веза)
^„Entrez Gene: PRLHR prolactin releasing hormone receptor”.

Dodatna literatura

[уреди |уреди извор]

Hinuma S, Onda H, Fujino M (1999). „The quest for novel bioactive peptides utilizing orphan seven-transmembrane-domain receptors.”.J. Mol. Med.77 (6): 495—504.PMID 10475064.doi:10.1007/s001090050403.
Marchese A; Heiber M; Nguyen T; et al. (1996). „Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors.”.Genomics.29 (2): 335—44.PMID 8666380.doi:10.1006/geno.1995.9996. CS1 одржавање: Експлицитна употреба et al. (веза)
Hinuma S; Habata Y; Fujii R; et al. (1998). „A prolactin-releasing peptide in the brain.”.Nature.393 (6682): 272—6.PMID 9607765.doi:10.1038/30515. CS1 одржавање: Експлицитна употреба et al. (веза)
Fujii R; Fukusumi S; Hosoya M; et al. (1999). „Tissue distribution of prolactin-releasing peptide (PrRP) and its receptor.”.Regul. Pept.83 (1): 1—10.PMID 10498338.doi:10.1016/S0167-0115(99)00028-2. CS1 одржавање: Експлицитна употреба et al. (веза)
Langmead CJ; Szekeres PG; Chambers JK; et al. (2000).„Characterization of the binding of [(125)I]-human prolactin releasing peptide (PrRP) to GPR10, a novel G protein coupled receptor.”.Br. J. Pharmacol.131 (4): 683—8.PMC 1572376 .PMID 11030716.doi:10.1038/sj.bjp.0703617. CS1 одржавање: Експлицитна употреба et al. (веза)
Lin SH; Arai AC; Wang Z; et al. (2001). „The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor clustering.”.Mol. Pharmacol.60 (5): 916—23.PMID 11641419. CS1 одржавање: Експлицитна употреба et al. (веза)
Takahashi K; Totsune K; Murakami O; et al. (2003). „Expression of prolactin-releasing peptide and its receptor in the human adrenal glands and tumor tissues of adrenocortical tumors, pheochromocytomas and neuroblastomas.”.Peptides.23 (6): 1135—40.PMID 12126742.doi:10.1016/S0196-9781(02)00046-3. CS1 одржавање: Експлицитна употреба et al. (веза)
Kemp DM, Lin JC, Ubeda M, Habener JF (2002). „NRSF/REST confers transcriptional repression of the GPR10 gene via a putative NRSE/RE-1 located in the 5' promoter region.”.FEBS Lett.531 (2): 193—8.PMID 12417311.doi:10.1016/S0014-5793(02)03502-0.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003).„Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”.Proc. Natl. Acad. Sci. U.S.A.99 (26): 16899—903.PMC 139241 .PMID 12477932.doi:10.1073/pnas.242603899. CS1 одржавање: Експлицитна употреба et al. (веза)
Bhattacharyya S; Luan J; Challis B; et al. (2003).„Association of polymorphisms in GPR10, the gene encoding the prolactin-releasing peptide receptor with blood pressure, but not obesity, in a U.K. Caucasian population.”.Diabetes.52 (5): 1296—9.PMID 12716769.doi:10.2337/diabetes.52.5.1296. CS1 одржавање: Експлицитна употреба et al. (веза)
Deloukas P; Earthrowl ME; Grafham DV; et al. (2004). „The DNA sequence and comparative analysis of human chromosome 10.”.Nature.429 (6990): 375—81.PMID 15164054.doi:10.1038/nature02462. CS1 одржавање: Експлицитна употреба et al. (веза)
Gerhard DS; Wagner L; Feingold EA; et al. (2004).„The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”.Genome Res.14 (10B): 2121—7.PMC 528928 .PMID 15489334.doi:10.1101/gr.2596504. CS1 одржавање: Експлицитна употреба et al. (веза)
Ellacott KL; Donald EL; Clarkson P; et al. (2005). „Characterization of a naturally-occurring polymorphism in the UHR-1 gene encoding the putative rat prolactin-releasing peptide receptor.”.Peptides.26 (4): 675—81.PMID 15752583.doi:10.1016/j.peptides.2004.11.020. CS1 одржавање: Експлицитна употреба et al. (веза)
Lagerström MC; Fredriksson R; Bjarnadóttir TK; et al. (2005). „Origin of the prolactin-releasing hormone (PRLH) receptors: evidence of coevolution between PRLH and a redundant neuropeptide Y receptor during vertebrate evolution.”.Genomics.85 (6): 688—703.PMID 15885496.doi:10.1016/j.ygeno.2005.02.007. CS1 одржавање: Експлицитна употреба et al. (веза)
Kimura K; Wakamatsu A; Suzuki Y; et al. (2006).„Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.”.Genome Res.16 (1): 55—65.PMC 1356129 .PMID 16344560.doi:10.1101/gr.4039406. CS1 одржавање: Експлицитна употреба et al. (веза)

Spoljašnje veze

[уреди |уреди извор]

„Prolactin-Releasing Peptide Receptor”.IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано изоригинала 03. 03. 2016. г.
PRLHR+protein,+human наUS National Library of Medicine Medical Subject Headings (MeSH)

Transmembranski receptor:receptori spregnuti s G proteinom

Klasa A:Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A,B,D) • α2 (A,B,C) • β1 • β2 • β3
Purinski	Adenozinski (A1,A2A,A2B,A3) • P2Y (1,2,4,5,6,8,9,10,11,12,13,14)
Serotoninski	(svi osim 5-HT3)5-HT1 (A,B,D,E,F) • 5-HT2 (A,B,C) • 5-HT (4,5A,6,7)
Drugi	Acetilholin (M1,M2,M3,M4,M5) • Dopamin (D1,D2,D3,D4,D5) • Histamin (H1,H2,H3,H4) • Melatonin (1A,1B,1C) • TAAR (1,2,3,5,6,8,9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1,2) • LTB4 (1,2) • FPRL1 • OXE • Prostaglandin (DP (1,2),EP (1,2,3,4),FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1,CB2,GPR (18,55,119)) • EBI2 • Estrogen • Slobodna masna kiselina (1,2,3,4) • Laktat • Lizofosfatidna kiselina (1,2,3,4,5,6) • Lizofosfolipid (1,2,3,4,5,6,7,8) • Niacin (1,2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1,2,3,4,5) • Sukcinat

Peptid

Neuropeptidni

B/W (1,2) • FF (1,2) • S • Y (1,2,4,5) • Neuromedin (B,U (1,2)) • Neurotenzin (1,2)

Drugi

Anafilatoksin (C3a,C5a) • Angiotenzin (1,2) • Apelin • Bombezin (BRS3,GRPR,NMBR) • Bradikinin (B1,B2) • Hemokin • Holecistokinin (A,B) • Endotelin (A,B) • Formil peptid (1,2,3) • FSH • Galanin (1,2,3) • GHB receptor • Gonadotropin-oslobađajući hormon (1,2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1,1L,D,E,F,G,X1,X2,X3,X4) • Melanokortin (1,2,3,4,5) • MCHR (1,2) • Motilin • Opioidni (δ,κ,μ,Nociceptin &ζ, ali neσ) • Oreksin (1,2) • Oksitocin • Prokineticin (1,2) • Prolaktin-oslobađajući peptid • Relaksin (1,2,3,4) • Somatostatin (1,2,3,4,5) • Tahikinin (1,2,3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A,1B,2)

Razno

Orfan	GPR (1,3,4,6,12,15,17,18,19,20,21,22,23,25,26,27,31,32,33,34,35,37,39,42,44,45,50,52,55,61,62,63,65,68,75,77,78,81,82,83,84,85,87,88,92,101,103,109A,109B,119,120,132,135,137B,139,141,142,146,148,149,150,151,152,153,160,161,162,171,173,174,176,177,182,183)
Drugi	Adrenomedulin • Mirisni • Opsin (3,4,5,1LW,1MW,1SW,RGR,RRH) • Proteazom-aktivirani (1,2,3,4) • SREB (1,2,3)

Klasa B:Sekretinu slični

Orfan	GPR (56,64,97,98,110,111,112,113,114,115,116,123,124,125,126,128,133,143,144,155,157)
Drugi	Moždano specifični angiogenezni inhibitor (1,2,3) • Kadherin (1,2,3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1,2) • EMR (1,2,3) • Glukagon (GR,GIPR,GLP1R,GLP2R) • Hormon rasta • PACAPR1 • GPR • Latrofilin (1,2,3,ELTD1) • Metuzalemski protein • Paratiroidni hormon (1,2) • Sekretin • Vazoaktivni intestinalni peptid (1,2)

Klasa C:Metabotropni
glutamat /feromon

Ukus	TAS1R (1,2,3) • TAS2R (1,3,4,5,8,9,10,12,13,14,16,19,20,30,31,38,39,40,41,42,43,45,46,50)
Drugi	Kalcijum-detektujući receptor • GABA B (1,2) • Glutamatni receptor (Metabotropni glutamat (1,2,3,4,5,6,7,8)) • GPRC6A • GPR (156,158,179) • RAIG (1,2,3,4) • VNR (1,2,3,5)

Klasa F:
Frizzled /Zaglađeni

Uvojiti	Frizzled (1,2,3,4,5,6,7,8,9,10)
Zaglađeni	Zaglađeni

Преузето из „https://sr.wikipedia.org/w/index.php?title=PRRP&oldid=27774519”

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