Hemijska struktura monensina je prvo opisana1967. godine (Agtarp et al.). To je bio prvi polietarski antibiotik. Prvi izveštaj o totalnoj sintezi monensina je objavljen1979. godine.[8]
Monensin A manifestuje naklonost ka formiranju kompleksa sa monovalentnimkatjonima kao što su Li+, Na+, K+, Rb+, Ag+ and Tl+[9][10][11][12]. Monensin A ima sposobnot transportovanja tih katjona kroz lipidne membrane ćelija, što mu daje značajnu ulogu Na+/H+antitransportera. On blokira intraćelijski proteinski transport, i posedujeantibiotička,antimalarijska, i druga biološka svojstva.[13].Antibakteriske osobine Monensina i njegovih derivata su rezultat njihove sposobnosti da transportuju metalne katjone kroz ćeliske i intraćeliskemembrane.[14][15][16].
Monenin je u širokoj upotrebi u industriji prerade mleka i mesa kao stredstvo za sprečavanjecocodiosisa, intenzivnog oslobađanja propionske kiselene.[17]. Monensin, monensin metilestar (MME), i posebno monensin decil estar (MDE) se široko koriste kao sastojak selectivnihelektroda.[18][19][20].
^Harvey BM; Hong H; Jones MA; et al. (2006). „Evidence that a novel thioesterase is responsible for polyketide chain release during biosynthesis of the polyether ionophore monensin”.Chembiochem.7 (9): 1435—42.PMID16897798.doi:10.1002/cbic.200500474.
^Li C, Hazzard C, Florova G, Reynolds KA (2009). „High titer production of tetracenomycins by heterologous expression of the pathway in a Streptomyces cinnamonensis industrial monensin producer strain”.Metab. Eng.11 (6): 319—27.PMID19595787.doi:10.1016/j.ymben.2009.06.004.
^Mollenhauer HH, Morré DJ, Rowe LD (1990). „Alteration of intracellular traffic by monensin; mechanism, specificity and relationship to toxicity”.Biochim. Biophys. Acta.1031 (2): 225—46.PMID2160275.
^Huczyński, Adam; Ratajczak-Sitarz, Małgorzata; Katrusiak, Andrzej; Brzezinski, Bogumil (2007). „Molecular structure of the 1:1 inclusion complex of monensin a lithium salt with acetonitrile”.Journal of Molecular Structure.871 (1–3): 92—97.Bibcode:2007JMoSt.871...92H.doi:10.1016/j.molstruc.2006.07.046.
^Huczyński, Adam; Ratajczak-Sitarz, Małgorzata; Katrusiak, Andrzej; Brzezinski, Bogumil (2007). „Molecular structure of the 1:1 inclusion complex of monensin a sodium salt with acetonitrile”.Journal of Molecular Structure.832 (1–3): 84—89.Bibcode:2007JMoSt.832...84H.doi:10.1016/j.molstruc.2006.07.043.
^Huczyński, Adam; Ratajczak-Sitarz, Małgorzata; Katrusiak, Andrzej; Brzezinski, Bogumil (2008). „Molecular structure of rubidium six-coordinated dihydrate complex with monensin A”.Journal of Molecular Structure.888 (1–3): 224—229.Bibcode:2008JMoSt.888..224H.doi:10.1016/j.molstruc.2007.12.005.
^M. Pinkerton, L. K. Steinrauf, "Molecular structure of monovalent metal cation complexes of monensin",J. Mol. Biol., 1970 49(3), 533-546
^Huczyński, Adam; Stefańska, Joanna; Przybylski, Piotr; Brzezinski, Bogumil; Bartl, Franz (2008). „Synthesis and antimicrobial properties of Monensin a esters”.Bioorganic & Medicinal Chemistry Letters.18 (8): 2585—2589.PMID18375122.doi:10.1016/j.bmcl.2008.03.038.
^Huczyñski, Adam; Przybylski, Piotr; Brzezinski, Bogumil; Bartl, Franz (2006). „Spectroscopic and Semiempirical Studies of a Proton Channel Formed by the Methyl Ester of Monensin A”.The Journal of Physical Chemistry B.110 (31): 15615—15623.PMID16884286.doi:10.1021/jp062160o.
^Huczyński, Adam; Domańska, Agata; Paluch, Izabela; Stefańska, Joanna; Brzezinski, Bogumil; Bartl, Franz (2008). „Synthesis of new semi-synthetic dipodands and tripodands from naturally occurring polyether ionophores”.Tetrahedron Letters.49 (39): 5572—5575.doi:10.1016/j.tetlet.2008.06.116.
^Matsuoka, T.; Novilla, M.N.; Thomson, T.D.; Donoho, A.L. (1996). „Review of monensin toxicosis in horses”.Journal of Equine Veterinary Science.16: 8—15.doi:10.1016/S0737-0806(96)80059-1.
^Tohda, Koji; Suzuki, Koji; Kosuge, Nobutaka; Nagashima, Hitoshi; Watanabe, Kazuhiko; Inoue, Hidenari; Shirai, Tsuneo (1990). „A Sodium Ion Selective Electrode Based on a Highly Lipophilic Monensin Derivative and Its Application to the Measurement of Sodium Ion Concentrations in Serum”.Analytical Sciences.6 (2): 227—232.doi:10.2116/analsci.6.227.
^Kim, Namsoo; Park, Kyung-rim; Park, In-Seon; Cho, Yong-Jin; Bae, Young Min (2005). „Application of a taste evaluation system to the monitoring of Kimchi fermentation☆”.Biosensors and Bioelectronics.20 (11): 2283—2291.PMID15797327.doi:10.1016/j.bios.2004.10.007.
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