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Mehitazin

С Википедије, слободне енциклопедије

Mehitazin
Klinički podaci

Prodajno ime	Butix, Instotal, Kitazemin, Metaplexan
Drugs.com	Monografija
Identifikatori
CAS broj	29216-28-2^Y
ATC kod	R06AD07 (WHO)
PubChem	CID4066
DrugBank	DB01071^Y
ChemSpider	3926^Y
KEGG	C12755^Y
Hemijski podaci
Formula	C₂₀H₂₂N₂S
Molarna masa	322,467
SMILES C(C1CN2CCC1CC2)N1C2=CC=CC=C2SC2=CC=CC=C12
InChI InChI=1S/C20H22N2S/c1-3-7-19-17(5-1)22(18-6-2-4-8-20(18)23-19)14-16-13-21-11-9-15(16)10-12-21/h1-8,15-16H,9-14H2^Y Key:HOKDBMAJZXIPGC-UHFFFAOYSA-N^Y

Fizički podaci
Tačka topljenja	1.305 °C (2.381 °F)

Mehitazin jeorgansko jedinjenje, koje sadrži 20atoma ugljenika i imamolekulsku masu od 322,467Da.^[1]^[2]^[3]^[4]^[5]^[6]

Osobine

[уреди |уреди извор]

Osobina	Vrednost
Broj akceptora vodonika	3
Broj donora vodonika	0
Broj rotacionih veza	2
Particioni koeficijent^[7] (ALogP)	4,4
Rastvorljivost^[8] (logS, log(mol/L))	-4,4
Polarna površina^[9] (PSA,Å²)	31,8

Reference

[уреди |уреди извор]

^Ramirez Chanona N, del Rio Navarro BE, Perez Martin J: [Efficacy of mequitazine (Primalan) on the relief of symptoms of allergic rhinoconjunctivitis in children. Documented clinical experience] Rev Alerg Mex. 2005 Nov-Dec;Ramírez Chanona, N.; Del Rio Navarro, B. E.; Pérez Martín, J. (2005). „Efficacy of mequitazine (Primalan) on the relief of symptoms of allergic rhinoconjunctivitis in children. Documented clinical experience”.Revista Alergia Mexico (Tecamachalco, Puebla, Mexico : 1993).52 (6): 221—5.PMID 16568706.
^Theunissen EL, Vermeeren A, van Oers AC, van Maris I, Ramaekers JG (2004 Feb). „A dose-ranging study of the effects of mequitazine on actual driving, memory and psychomotor performance as compared to dexchlorpheniramine, cetirizine and placebo”.Clin Exp Allergy.34 (2): 250—8.PMID 14987305.doi:10.1111/j.1365-2222.2004.01874.x. Проверите вредност парамет(а)ра за датум:|date= (помоћ)CS1 одржавање: Вишеструка имена: списак аутора (веза)
^Nakamura K, Yokoi T, Kodama T, Inoue K, Nagashima K, Shimada N, Shimizu T, Kamataki T (1998 Feb). „Oxidation of histamine H1 antagonist mequitazine is catalyzed by cytochrome P450 2D6 in human liver microsomes”.J Pharmacol Exp Ther.284 (2): 437—42.PMID 9454781.doi:10.1016/S0022-3565(24)37273-8. Проверите вредност парамет(а)ра за датум:|date= (помоћ)CS1 одржавање: Вишеструка имена: списак аутора (веза)
^Persi L, Dupin O, Arnaud B, Trinquand C, Michel FB, Bousquet J: Efficacy of mequitazine in comparison with placebo assessed by ocular challenge with allergen in allergic conjunctivitis. Allergy.Persi, L.; Dupin, O.; Arnaud, B.; Trinquand, C.; Michel, F. B.; Bousquet, J. (1997 Apr). „Efficacy of mequitazine in comparison with placebo assessed by ocular challenge with allergen in allergic conjunctivitis”.Allergy.52 (4): 451—4.PMID 9188930.doi:10.1111/j.1398-9995.1997.tb01028.x. Проверите вредност парамет(а)ра за датум:|date= (помоћ)
^Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011).„DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”.Nucleic Acids Research.39 (Database issue): D1035—D1041.PMC 3013709 .PMID 21059682.doi:10.1093/nar/gkq1126.
^Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008).„DrugBank: A knowledgebase for drugs, drug actions and drug targets”.Nucleic Acids Research.36 (Database issue): D901—D906.PMC 2238889 .PMID 18048412.doi:10.1093/nar/gkm958.
^Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”.The Journal of Physical Chemistry A.102 (21): 3762—3772.Bibcode:1998JPCA..102.3762G.doi:10.1021/jp980230o.
^Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”.Journal of Chemical Information and Computer Sciences.41 (6): 1488—1493.PMID 11749573.doi:10.1021/ci000392t.
^Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”.Journal of Medicinal Chemistry.43 (20): 3714—3717.PMID 11020286.doi:10.1021/jm000942e.