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LPAR6

Уреди везе

С Википедије, слободне енциклопедије

Receptor lizofosfatidne kiseline 6

Identifikatori

Simboli

LPAR6; MGC120358; P2Y5; P2RY5

Vanjski ID

OMIM: 609239MGI: 1914418HomoloGene: 55925IUPHAR:GeneCards:LPAR6 Gene

Ontologija gena
Molekularna funkcija	•aktivnost rodopsinu-sličnog receptora •receptorska aktivnost •aktivnost purinskog nukleotidnog receptora, G-protein spregnuti
Celularna komponenta	•membrana •integralno sa membranom
Biološki proces	•prenos signala •signalni put G-protein spregnutog receptora

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

RefSeq (mRNA)

RefSeq (protein)

Lokacija (UCSC)

Chr 13:
47.88 - 47.89 Mb

Chr 14:
71.97 - 71.97 Mb

PubMed pretraga

[1]

[2]

LPAR6 (receptor lizofosfatidne kiseline 6,LPA₆,P2RY5) jeprotein je protein koji je kod ljudi kodiranLPAR6genom.^[1]^[2]^[3]^[4] LPA₆ jeG protein-spregnuti receptor koji vezuje lipidni signalni molekullizofosfatidnu kiselinu (LPA).^[5]^[6]

Protein kodiran ovim genom pripada familiji G-protein spregnutih receptora, koji su preferentno aktiviraninukleotidima adenozina iuridina.^[4]

Uloga u rastu/gubitku kose

[уреди |уреди извор]

Februara2008 istraživači saBonskog univerziteta su objavili da su pronašli genetsku osnovu za dva oblika naslednog gubitka kose. Oni su utvrdili da gen P2RY5 uzrokuje retku, naslednu formugubitka kose koja se nazivaHypotrichosis simplex. To je bio prvi humanireceptor za koji je poznato da učestvuje u rastu kose.^[5]

Vidi još

[уреди |уреди извор]

Literatura

[уреди |уреди извор]

^Adrian K, Bernhard MK, Breitinger HG, Ogilvie A (2000). „Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells”.Biochim Biophys Acta.1492 (1): 127—38.PMID 11004484.
^Ralevic V, Burnstock G (1998). „Receptors for purines and pyrimidines”.Pharmacol Rev.50 (3): 413—92.PMID 9755289.
^Yanagida K, Masago K, Nakanishi H, Kihara Y, Hamano F, Tajima Y, Taguchi R, Shimizu T, Ishii S (2009).„Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6”.J Biol Chem.284 (26): 17731—41.PMC 2719412 .PMID 19386608.doi:10.1074/jbc.M808506200.
^^а ^б„Entrez Gene: P2RY5 purinergic receptor P2Y, G-protein coupled, 5”.
^^а ^бPasternack SM, von Kügelgen I, Aboud KA, Lee YA, Rüschendorf F, Voss K, Hillmer AM, Molderings GJ, Franz T, Ramirez A, Nürnberg P, Nöthen MM, Betz RC (2008). „G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth”.Nat. Genet.40 (3): 329—34.PMID 18297070.doi:10.1038/ng.84.
^Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (2010). „LPA Receptors: Subtypes and Biological Actions”.Annual Review of Pharmacology and Toxicology.50 (1): 157—186.PMID 20055701.doi:10.1146/annurev.pharmtox.010909.105753.

Dodatna literatura

[уреди |уреди извор]

Toguchida, J.; McGee, T. L.; Paterson, J. C.; et al. (1993). „Complete genomic sequence of the human retinoblastoma susceptibility gene.”.Genomics.17 (3): 535—43.PMID 7902321.doi:10.1006/geno.1993.1368.
Maruyama K, Sugano S (1994).„Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.”.Gene.138 (1-2): 171—4.PMID 8125298.doi:10.1016/0378-1119(94)90802-8.
Herzog H, Darby K, Hort YJ, Shine J (1997). „Intron 17 of the human retinoblastoma susceptibility gene encodes an actively transcribed G protein-coupled receptor gene.”.Genome Res.6 (9): 858—61.PMID 8889552.doi:10.1101/gr.6.9.858.
Li Q, Schachter JB, Harden TK, Nicholas RA (1997). „The 6H1 orphan receptor, claimed to be the p2y5 receptor, does not mediate nucleotide-promoted second messenger responses.”.Biochem. Biophys. Res. Commun.236 (2): 455—60.PMID 9240460.doi:10.1006/bbrc.1997.6984.
Suzuki, Y.; Yoshitomo-Nakagawa K; Maruyama, K.; et al. (1997).„Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.”.Gene.200 (1-2): 149—56.PMID 9373149.doi:10.1016/S0378-1119(97)00411-3.
Strausberg, R. L.; Feingold, E. A.; Grouse, L. H.; et al. (2003).„Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”.Proc. Natl. Acad. Sci. U.S.A.99 (26): 16899—903.PMC 139241 .PMID 12477932.doi:10.1073/pnas.242603899.
Ota, T.; Y, Suzuki; Nishikawa, T.; et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs.”.Nat. Genet.36 (1): 40—5.PMID 14702039.doi:10.1038/ng1285.
Dunham, A.; Matthews, L. H.; Burton, J.; et al. (2004).„The DNA sequence and analysis of human chromosome 13.”.Nature.428 (6982): 522—8.PMC 2665288 .PMID 15057823.doi:10.1038/nature02379.
Gerhard, D. S.; Wagner, L.; Feingold, E. A.; et al. (2004).„The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”.Genome Res.14 (10B): 2121—7.PMC 528928 .PMID 15489334.doi:10.1101/gr.2596504.
Ihara H, Hirukawa K, Goto S, Togari A (2005). „ATP-stimulated interleukin-6 synthesis through P2Y receptors on human osteoblasts.”.Biochem. Biophys. Res. Commun.326 (2): 329—34.PMID 15582581.doi:10.1016/j.bbrc.2004.11.037.

Transmembranski receptor:receptori spregnuti s G proteinom

Klasa A:Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A,B,D) • α2 (A,B,C) • β1 • β2 • β3
Purinski	Adenozinski (A1,A2A,A2B,A3) • P2Y (1,2,4,5,6,8,9,10,11,12,13,14)
Serotoninski	(svi osim 5-HT3)5-HT1 (A,B,D,E,F) • 5-HT2 (A,B,C) • 5-HT (4,5A,6,7)
Drugi	Acetilholin (M1,M2,M3,M4,M5) • Dopamin (D1,D2,D3,D4,D5) • Histamin (H1,H2,H3,H4) • Melatonin (1A,1B,1C) • TAAR (1,2,3,5,6,8,9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1,2) • LTB4 (1,2) • FPRL1 • OXE • Prostaglandin (DP (1,2),EP (1,2,3,4),FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1,CB2,GPR (18,55,119)) • EBI2 • Estrogen • Slobodna masna kiselina (1,2,3,4) • Laktat • Lizofosfatidna kiselina (1,2,3,4,5,6) • Lizofosfolipid (1,2,3,4,5,6,7,8) • Niacin (1,2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1,2,3,4,5) • Sukcinat

Peptid

Neuropeptidni

B/W (1,2) • FF (1,2) • S • Y (1,2,4,5) • Neuromedin (B,U (1,2)) • Neurotenzin (1,2)

Drugi

Anafilatoksin (C3a,C5a) • Angiotenzin (1,2) • Apelin • Bombezin (BRS3,GRPR,NMBR) • Bradikinin (B1,B2) • Hemokin • Holecistokinin (A,B) • Endotelin (A,B) • Formil peptid (1,2,3) • FSH • Galanin (1,2,3) • GHB receptor • Gonadotropin-oslobađajući hormon (1,2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1,1L,D,E,F,G,X1,X2,X3,X4) • Melanokortin (1,2,3,4,5) • MCHR (1,2) • Motilin • Opioidni (δ,κ,μ,Nociceptin &ζ, ali neσ) • Oreksin (1,2) • Oksitocin • Prokineticin (1,2) • Prolaktin-oslobađajući peptid • Relaksin (1,2,3,4) • Somatostatin (1,2,3,4,5) • Tahikinin (1,2,3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A,1B,2)

Razno

Orfan	GPR (1,3,4,6,12,15,17,18,19,20,21,22,23,25,26,27,31,32,33,34,35,37,39,42,44,45,50,52,55,61,62,63,65,68,75,77,78,81,82,83,84,85,87,88,92,101,103,109A,109B,119,120,132,135,137B,139,141,142,146,148,149,150,151,152,153,160,161,162,171,173,174,176,177,182,183)
Drugi	Adrenomedulin • Mirisni • Opsin (3,4,5,1LW,1MW,1SW,RGR,RRH) • Proteazom-aktivirani (1,2,3,4) • SREB (1,2,3)

Klasa B:Sekretinu slični

Orfan	GPR (56,64,97,98,110,111,112,113,114,115,116,123,124,125,126,128,133,143,144,155,157)
Drugi	Moždano specifični angiogenezni inhibitor (1,2,3) • Kadherin (1,2,3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1,2) • EMR (1,2,3) • Glukagon (GR,GIPR,GLP1R,GLP2R) • Hormon rasta • PACAPR1 • GPR • Latrofilin (1,2,3,ELTD1) • Metuzalemski protein • Paratiroidni hormon (1,2) • Sekretin • Vazoaktivni intestinalni peptid (1,2)

Klasa C:Metabotropni
glutamat /feromon

Ukus	TAS1R (1,2,3) • TAS2R (1,3,4,5,8,9,10,12,13,14,16,19,20,30,31,38,39,40,41,42,43,45,46,50)
Drugi	Kalcijum-detektujući receptor • GABA B (1,2) • Glutamatni receptor (Metabotropni glutamat (1,2,3,4,5,6,7,8)) • GPRC6A • GPR (156,158,179) • RAIG (1,2,3,4) • VNR (1,2,3,5)

Klasa F:
Frizzled /Zaglađeni

Uvojiti	Frizzled (1,2,3,4,5,6,7,8,9,10)
Zaglađeni	Zaglađeni

Преузето из „https://sr.wikipedia.org/w/index.php?title=LPAR6&oldid=30647131”

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