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LPAR4

Уреди везе

С Википедије, слободне енциклопедије

Receptor lizofosfatidne kiseline 4

Identifikatori

Simboli

LPAR4; GPR23; LPA4; P2RY9; P2Y5-LIKE; P2Y9

Vanjski ID

OMIM: 300086MGI: 1925384HomoloGene: 3871IUPHAR:GeneCards:LPAR4 Gene

Ontologija gena
Molekularna funkcija	•aktivnost rodopsinu-sličnog receptora •receptorska aktivnost •vezivanje lipida •aktivnost purinergičkog nukleotidnog receptora, G-protein spregnutog
Celularna komponenta	•integralno sa ćelijskom membranom •membrana
Biološki proces	•prenos signala •signalni put G-protein spregnutog receptora

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

RefSeq (mRNA)

RefSeq (protein)

Lokacija (UCSC)

Chr X:
77.9 - 77.9 Mb

Chr X:
103.12 - 103.14 Mb

PubMed pretraga

[1]

[2]

LPAR4,receptor lizofosfatidne kiseline 4 iliLPA₄, jeprotein koji je kod čoveka kodiranLPAR4genom.^[1]^[2]^[3] LPA₄ jeG protein-spregnuti receptor koji vezuje lipidni signalni molekullizofosfatidnu kiselinu (LPA).^[4]

Vidi još

[уреди |уреди извор]

Literatura

[уреди |уреди извор]

^„Entrez Gene: GPR23 G protein-coupled receptor 23”.
^Janssens R, Boeynaems JM, Godart M, Communi D (1997). „Cloning of a human heptahelical receptor closely related to the P2Y5 receptor”.Biochem. Biophys. Res. Commun.236 (1): 106—12.PMID 9223435.doi:10.1006/bbrc.1997.6895.
^O'Dowd BF, Nguyen T, Jung BP, Marchese A, Cheng R, Heng HH, Kolakowski LF, Lynch KR, George SR (1997).„Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes”.Gene.187 (1): 75—81.PMID 9073069.doi:10.1016/S0378-1119(96)00722-6.
^Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (2010). „LPA Receptors: Subtypes and Biological Actions”.Annual Review of Pharmacology and Toxicology.50 (1): 157—186.PMID 20055701.doi:10.1146/annurev.pharmtox.010909.105753.

Dodatna literatura

[уреди |уреди извор]

Adrian K, Bernhard MK, Breitinger HG, Ogilvie A (2000). „Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells.”.Biochim. Biophys. Acta.1492 (1): 127—38.PMID 11004484.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003).„Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”.Proc. Natl. Acad. Sci. U.S.A.99 (26): 16899—903.PMC 139241 .PMID 12477932.doi:10.1073/pnas.242603899.
Noguchi K, Ishii S, Shimizu T (2003).„Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family.”.J. Biol. Chem.278 (28): 25600—6.PMID 12724320.doi:10.1074/jbc.M302648200.
Gerhard DS; Wagner L; Feingold EA; et al. (2004).„The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”.Genome Res.14 (10B): 2121—7.PMC 528928 .PMID 15489334.doi:10.1101/gr.2596504.
Ross MT; Grafham DV; Coffey AJ; et al. (2005).„The DNA sequence of the human X chromosome.”.Nature.434 (7031): 325—37.PMC 2665286 .PMID 15772651.doi:10.1038/nature03440.
Liu T; Qian WJ; Gritsenko MA; et al. (2006).„Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.”.J. Proteome Res.4 (6): 2070—80.PMC 1850943 .PMID 16335952.doi:10.1021/pr0502065.

Transmembranski receptor:receptori spregnuti s G proteinom

Klasa A:Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A,B,D) • α2 (A,B,C) • β1 • β2 • β3
Purinski	Adenozinski (A1,A2A,A2B,A3) • P2Y (1,2,4,5,6,8,9,10,11,12,13,14)
Serotoninski	(svi osim 5-HT3)5-HT1 (A,B,D,E,F) • 5-HT2 (A,B,C) • 5-HT (4,5A,6,7)
Drugi	Acetilholin (M1,M2,M3,M4,M5) • Dopamin (D1,D2,D3,D4,D5) • Histamin (H1,H2,H3,H4) • Melatonin (1A,1B,1C) • TAAR (1,2,3,5,6,8,9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1,2) • LTB4 (1,2) • FPRL1 • OXE • Prostaglandin (DP (1,2),EP (1,2,3,4),FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1,CB2,GPR (18,55,119)) • EBI2 • Estrogen • Slobodna masna kiselina (1,2,3,4) • Laktat • Lizofosfatidna kiselina (1,2,3,4,5,6) • Lizofosfolipid (1,2,3,4,5,6,7,8) • Niacin (1,2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1,2,3,4,5) • Sukcinat

Peptid

Neuropeptidni

B/W (1,2) • FF (1,2) • S • Y (1,2,4,5) • Neuromedin (B,U (1,2)) • Neurotenzin (1,2)

Drugi

Anafilatoksin (C3a,C5a) • Angiotenzin (1,2) • Apelin • Bombezin (BRS3,GRPR,NMBR) • Bradikinin (B1,B2) • Hemokin • Holecistokinin (A,B) • Endotelin (A,B) • Formil peptid (1,2,3) • FSH • Galanin (1,2,3) • GHB receptor • Gonadotropin-oslobađajući hormon (1,2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1,1L,D,E,F,G,X1,X2,X3,X4) • Melanokortin (1,2,3,4,5) • MCHR (1,2) • Motilin • Opioidni (δ,κ,μ,Nociceptin &ζ, ali neσ) • Oreksin (1,2) • Oksitocin • Prokineticin (1,2) • Prolaktin-oslobađajući peptid • Relaksin (1,2,3,4) • Somatostatin (1,2,3,4,5) • Tahikinin (1,2,3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A,1B,2)

Razno

Orfan	GPR (1,3,4,6,12,15,17,18,19,20,21,22,23,25,26,27,31,32,33,34,35,37,39,42,44,45,50,52,55,61,62,63,65,68,75,77,78,81,82,83,84,85,87,88,92,101,103,109A,109B,119,120,132,135,137B,139,141,142,146,148,149,150,151,152,153,160,161,162,171,173,174,176,177,182,183)
Drugi	Adrenomedulin • Mirisni • Opsin (3,4,5,1LW,1MW,1SW,RGR,RRH) • Proteazom-aktivirani (1,2,3,4) • SREB (1,2,3)

Klasa B:Sekretinu slični

Orfan	GPR (56,64,97,98,110,111,112,113,114,115,116,123,124,125,126,128,133,143,144,155,157)
Drugi	Moždano specifični angiogenezni inhibitor (1,2,3) • Kadherin (1,2,3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1,2) • EMR (1,2,3) • Glukagon (GR,GIPR,GLP1R,GLP2R) • Hormon rasta • PACAPR1 • GPR • Latrofilin (1,2,3,ELTD1) • Metuzalemski protein • Paratiroidni hormon (1,2) • Sekretin • Vazoaktivni intestinalni peptid (1,2)

Klasa C:Metabotropni
glutamat /feromon

Ukus	TAS1R (1,2,3) • TAS2R (1,3,4,5,8,9,10,12,13,14,16,19,20,30,31,38,39,40,41,42,43,45,46,50)
Drugi	Kalcijum-detektujući receptor • GABA B (1,2) • Glutamatni receptor (Metabotropni glutamat (1,2,3,4,5,6,7,8)) • GPRC6A • GPR (156,158,179) • RAIG (1,2,3,4) • VNR (1,2,3,5)

Klasa F:
Frizzled /Zaglađeni

Uvojiti	Frizzled (1,2,3,4,5,6,7,8,9,10)
Zaglađeni	Zaglađeni

Преузето из „https://sr.wikipedia.org/w/index.php?title=LPAR4&oldid=30647125”

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