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LPAR1

Уреди везе

С Википедије, слободне енциклопедије

Receptor lizofosfatidne kiseline 1

Identifikatori

Simboli

LPAR1; EDG2; LPA1; Mrec1.3; VZG1; edg-2; rec.1.3; vzg-1

Vanjski ID

OMIM: 602282MGI: 108429HomoloGene: 1072IUPHAR:LPA₁GeneCards:LPAR1 Gene

Ontologija gena
Molekularna funkcija	•vezivanje G-protein alfa podjedinice •aktivnost G-protein spregnutog receptora •proteinsko vezivanje •fosfolipidno vezivanje
Celularna komponenta	•citoplazma •ćelijska membrana •integralno sa ćelijskom membranom •ćelijska površina
Biološki proces	•activacija MAPK aktivnosti •signalni put G-protein spregnutog receptora •aktivacija fosfolipaze C •povišenje koncentracije citozolnih jona kalcijuma

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

RefSeq (mRNA)

RefSeq (protein)

Lokacija (UCSC)

Chr 9:
113.64 - 113.8 Mb

Chr 4:
58.45 - 58.57 Mb

PubMed pretraga

[1]

[2]

Receptor lizofosfatidne kiseline 1 (LPA₁) jeprotein koji je kod ljudi kodiranLPAR1genom.^[1]^[2]^[3] LPA₁ jeG protein spregnuti receptor za koji se vezuje lipidni signalni molekullizofosfatidna kiselina (LPA).^[4]

Funkcija

[уреди |уреди извор]

Integralni membranski protein kodiran ovim genom pripada grupiEDG receptora. Ti receptori su članovi familije G protein spregnutih receptora. EDG receptori posreduju različite bioločkie funkcije, uključujući proliferaciju, agregaciju trombocita, kontrakcije glatkih mišića, inhibiciju diferencijaciju neuroblastomnih ćelija,hemotaksu, i invaziju tumornih ćelija.Alternativno splajsovanje ovog gena je uočeno i dve transkriptne varijante su opisane. One kodiraju identične proteine.^[1]

Reference

[уреди |уреди извор]

^^а ^б„Entrez Gene: LPAR1 Lysophosphatidic acid receptor 1”.
^Hecht JH, Weiner JA, Post SR, Chun J (1996).„Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex”.J. Cell Biol.135 (4): 1071—83.PMC 2133395 .PMID 8922387.doi:10.1083/jcb.135.4.1071.
^An S, Dickens MA, Bleu T, Hallmark OG, Goetzl EJ (1997). „Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid”.Biochem. Biophys. Res. Commun.231 (3): 619—22.PMID 9070858.doi:10.1006/bbrc.1997.6150.
^Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (2010). „LPA Receptors: Subtypes and Biological Actions”.Annual Review of Pharmacology and Toxicology.50 (1): 157—186.PMID 20055701.doi:10.1146/annurev.pharmtox.010909.105753.

Literatura

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An S, Goetzl EJ, Lee H (1999). „Signaling mechanisms and molecular characteristics of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate.”.J. Cell. Biochem. Suppl. 30-31: 147—57.PMID 9893266.
Contos JJ, Ishii I, Chun J (2001). „Lysophosphatidic acid receptors.”.Mol. Pharmacol.58 (6): 1188—96.PMID 11093753.
Moolenaar WH, Kranenburg O, Postma FR, Zondag GC (1997). „Lysophosphatidic acid: G-protein signalling and cellular responses.”.Curr. Opin. Cell Biol.9 (2): 168—73.PMID 9069262.doi:10.1016/S0955-0674(97)80059-2.
Fukushima N, Kimura Y, Chun J (1998).„A single receptor encoded by vzg-1/lpA1/edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid.”.Proc. Natl. Acad. Sci. U.S.A.95 (11): 6151—6.PMC 27607 .PMID 9600933.doi:10.1073/pnas.95.11.6151.
An S, Bleu T, Zheng Y, Goetzl EJ (1998). „Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization.”.Mol. Pharmacol.54 (5): 881—8.PMID 9804623.
Cervera, P.; M, Tirard; Barron, S.; et al. (2002). „Immunohistological localization of the myelinating cell-specific receptor LP(A1).”.Glia.38 (2): 126—36.PMID 11948806.doi:10.1002/glia.10054.
Hama, K.; K, Bandoh; Kakehi, Y.; et al. (2002). „Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA-binding proteins in activation of LPA receptors.”.FEBS Lett.523 (1-3): 187—92.PMID 12123830.doi:10.1016/S0014-5793(02)02976-9.
Van Leeuwen FN; Olivo, C.; S, Grivell; et al. (2003). „Rac activation by lysophosphatidic acid LPA1 receptors through the guanine nucleotide exchange factor Tiam1.”.J. Biol. Chem.278 (1): 400—6.PMID 12393875.doi:10.1074/jbc.M210151200.
Strausberg, R. L.; Feingold, E. A.; Grouse, L. H.; et al. (2003).„Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”.Proc. Natl. Acad. Sci. U.S.A.99 (26): 16899—903.PMC 139241 .PMID 12477932.doi:10.1073/pnas.242603899.
Murph MM, Scaccia LA, Volpicelli LA, Radhakrishna H (2004). „Agonist-induced endocytosis of lysophosphatidic acid-coupled LPA1/EDG-2 receptors via a dynamin2- and Rab5-dependent pathway.”.J. Cell. Sci.116 (Pt 10): 1969—80.PMID 12668728.doi:10.1242/jcs.00397.
Shida, D.; J, Kitayama; Yamaguchi, H.; et al. (2003). „Lysophosphatidic acid (LPA) enhances the metastatic potential of human colon carcinoma DLD1 cells through LPA1.”.Cancer Res.63 (7): 1706—11.PMID 12670925.
Matsuda, A.; Y, Suzuki; Honda, G.; et al. (2003). „Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.”.Oncogene.22 (21): 3307—18.PMID 12761501.doi:10.1038/sj.onc.1206406.
Xu J, Lai YJ, Lin WC, Lin FT (2004). „TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor.”.J. Biol. Chem.279 (11): 10459—68.PMID 14688263.doi:10.1074/jbc.M311891200.
Komuro, Y.; T, Watanabe; Kitayama, J.; et al. (2004). „The Immunohistochemical expression of endothelial cell differentiation gene-2 receptor in human colorectal adenomas.”.Hepatogastroenterology.50 (54): 1770—3.PMID 14696401.
Ota, T.; Y, Suzuki; Nishikawa, T.; et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs.”.Nat. Genet.36 (1): 40—5.PMID 14702039.doi:10.1038/ng1285.
Kaneider, N. C.; Lindner, J.; C, Feistritzer; et al. (2005). „The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor.”.FASEB J.18 (11): 1309—11.PMID 15208267.doi:10.1096/fj.03-1050fje.

Vidi još

[уреди |уреди извор]

Lizofosfolipidni receptor

Spoljašnje veze

[уреди |уреди извор]

„Lysophospholipid Receptors: LPA₁”.IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано изоригинала 03. 03. 2016. г.
Lysophospholipid+receptors наUS National Library of Medicine Medical Subject Headings (MeSH)

Transmembranski receptor:receptori spregnuti s G proteinom

Klasa A:Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A,B,D) • α2 (A,B,C) • β1 • β2 • β3
Purinski	Adenozinski (A1,A2A,A2B,A3) • P2Y (1,2,4,5,6,8,9,10,11,12,13,14)
Serotoninski	(svi osim 5-HT3)5-HT1 (A,B,D,E,F) • 5-HT2 (A,B,C) • 5-HT (4,5A,6,7)
Drugi	Acetilholin (M1,M2,M3,M4,M5) • Dopamin (D1,D2,D3,D4,D5) • Histamin (H1,H2,H3,H4) • Melatonin (1A,1B,1C) • TAAR (1,2,3,5,6,8,9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1,2) • LTB4 (1,2) • FPRL1 • OXE • Prostaglandin (DP (1,2),EP (1,2,3,4),FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1,CB2,GPR (18,55,119)) • EBI2 • Estrogen • Slobodna masna kiselina (1,2,3,4) • Laktat • Lizofosfatidna kiselina (1,2,3,4,5,6) • Lizofosfolipid (1,2,3,4,5,6,7,8) • Niacin (1,2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1,2,3,4,5) • Sukcinat

Peptid

Neuropeptidni

B/W (1,2) • FF (1,2) • S • Y (1,2,4,5) • Neuromedin (B,U (1,2)) • Neurotenzin (1,2)

Drugi

Anafilatoksin (C3a,C5a) • Angiotenzin (1,2) • Apelin • Bombezin (BRS3,GRPR,NMBR) • Bradikinin (B1,B2) • Hemokin • Holecistokinin (A,B) • Endotelin (A,B) • Formil peptid (1,2,3) • FSH • Galanin (1,2,3) • GHB receptor • Gonadotropin-oslobađajući hormon (1,2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1,1L,D,E,F,G,X1,X2,X3,X4) • Melanokortin (1,2,3,4,5) • MCHR (1,2) • Motilin • Opioidni (δ,κ,μ,Nociceptin &ζ, ali neσ) • Oreksin (1,2) • Oksitocin • Prokineticin (1,2) • Prolaktin-oslobađajući peptid • Relaksin (1,2,3,4) • Somatostatin (1,2,3,4,5) • Tahikinin (1,2,3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A,1B,2)

Razno

Orfan	GPR (1,3,4,6,12,15,17,18,19,20,21,22,23,25,26,27,31,32,33,34,35,37,39,42,44,45,50,52,55,61,62,63,65,68,75,77,78,81,82,83,84,85,87,88,92,101,103,109A,109B,119,120,132,135,137B,139,141,142,146,148,149,150,151,152,153,160,161,162,171,173,174,176,177,182,183)
Drugi	Adrenomedulin • Mirisni • Opsin (3,4,5,1LW,1MW,1SW,RGR,RRH) • Proteazom-aktivirani (1,2,3,4) • SREB (1,2,3)

Klasa B:Sekretinu slični

Orfan	GPR (56,64,97,98,110,111,112,113,114,115,116,123,124,125,126,128,133,143,144,155,157)
Drugi	Moždano specifični angiogenezni inhibitor (1,2,3) • Kadherin (1,2,3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1,2) • EMR (1,2,3) • Glukagon (GR,GIPR,GLP1R,GLP2R) • Hormon rasta • PACAPR1 • GPR • Latrofilin (1,2,3,ELTD1) • Metuzalemski protein • Paratiroidni hormon (1,2) • Sekretin • Vazoaktivni intestinalni peptid (1,2)

Klasa C:Metabotropni
glutamat /feromon

Ukus	TAS1R (1,2,3) • TAS2R (1,3,4,5,8,9,10,12,13,14,16,19,20,30,31,38,39,40,41,42,43,45,46,50)
Drugi	Kalcijum-detektujući receptor • GABA B (1,2) • Glutamatni receptor (Metabotropni glutamat (1,2,3,4,5,6,7,8)) • GPRC6A • GPR (156,158,179) • RAIG (1,2,3,4) • VNR (1,2,3,5)

Klasa F:
Frizzled /Zaglađeni

Uvojiti	Frizzled (1,2,3,4,5,6,7,8,9,10)
Zaglađeni	Zaglađeni

Преузето из „https://sr.wikipedia.org/w/index.php?title=LPAR1&oldid=27776098”

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