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Katin

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Katin
Klinički podaci


Drugs.com	Monografija
Farmakokinetički podaci
Poluvreme eliminacije	5,2 +/- 3,4 h

Identifikatori
CAS broj	492-39-7^Да
ATC kod	A08AA07 (WHO)
PubChem	CID441457
DrugBank	DB01486^Да
ChemSpider	390189^Да
KEGG	C08300^Да
Hemijski podaci
Formula	C₉H₁₃NO
Molarna masa	151,206
SMILES C[C@H](N)[C@@H](O)C1=CC=CC=C1
InChI InChI=1S/C9H13NO/c1-7(10)9(11)8-5-3-2-4-6-8/h2-7,9,11H,10H2,1H3/t7-,9+/m0/s1^Да Key:DLNKOYKMWOXYQA-IONNQARKSA-N^Да

Fizički podaci
Tačka topljenja	775—78 °C (1.427—172 °F)

Katin jeorgansko jedinjenje, koje sadrži 9atoma ugljenika i imamolekulsku masu od 151,206Da.^[1]^[2]^[3]

Osobine

[уреди |уреди извор]

Osobina	Vrednost
Broj akceptora vodonika	2
Broj donora vodonika	2
Broj rotacionih veza	2
Particioni koeficijent^[4] (ALogP)	0,8
Rastvorljivost^[5] (logS, log(mol/L))	-1,8
Polarna površina^[6] (PSA,Å²)	46,3

Reference

[уреди |уреди извор]

^Toennes SW, Harder S, Schramm M, Niess C, Kauert GF: Pharmacokinetics of cathinone, cathine and norephedrine after the chewing of khat leaves.Toennes, Stefan W.; Harder, Sebastian; Schramm, Markus; Niess, Constanze; Kauert, Gerold F. (2003 Jul). „Pharmacokinetics of cathinone, cathine and norephedrine after the chewing of khat leaves”.Br J Clin Pharmacol.56 (1): 125—30.PMID 12848785.doi:10.1046/j.1365-2125.2003.01834.x. Проверите вредност парамет(а)ра за датум:|date= (помоћ)
^Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011).„DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”.Nucleic Acids Research.39 (Database issue): D1035—D1041.PMC 3013709 .PMID 21059682.doi:10.1093/nar/gkq1126.
^Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008).„DrugBank: A knowledgebase for drugs, drug actions and drug targets”.Nucleic Acids Research.36 (Database issue): D901—D906.PMC 2238889 .PMID 18048412.doi:10.1093/nar/gkm958.
^Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”.The Journal of Physical Chemistry A.102 (21): 3762—3772.Bibcode:1998JPCA..102.3762G.doi:10.1021/jp980230o.
^Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”.Journal of Chemical Information and Computer Sciences.41 (6): 1488—1493.PMID 11749573.doi:10.1021/ci000392t.
^Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”.Journal of Medicinal Chemistry.43 (20): 3714—3717.PMID 11020286.doi:10.1021/jm000942e.