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GPRC5C

Уреди везе

С Википедије, слободне енциклопедије

G protein spregnuti receptor, familija C, grupa 5, član C

Identifikatori

Simboli

GPRC5C; RAIG-3; RAIG3

Vanjski ID

OMIM: 605949MGI: 1917605HomoloGene: 11099IUPHAR:RAIG₃GeneCards:GPRC5C Gene

Ontologija gena
Molekularna funkcija	•aktivnost G protein spregnutog receptora
Celularna komponenta	•Goldžijev aparat •ćelijska membrana •integralno sa ćelijskom membranom •membrana citoplazmičnih vezikula
Biološki proces	•prenos signala •signalni put G protein spregnutog receptora

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

RefSeq (mRNA)

RefSeq (protein)

Lokacija (UCSC)

Chr 17:
72.43 - 72.45 Mb

Chr 11:
114.71 - 114.73 Mb

PubMed pretraga

[1]

[2]

G protein spregnuti receptor, familija C, grupa 5, član C jeprotein koji je kod ljudi kodiranGPRC5Cgenom.^[1]^[2]

Ovaj protein pripada familiji tipa 3 G protein spregnutih receptora, koja ima karakteristični 7-transmembranski domen. On potencijalno učestvuje u interakciji između retinoidne kiseline i G protein signalnih puteva. Retinoinska kiselina ima kritičnu ulogu u razvoju, ćelijskom rastu, i diferencijaciji. Ovaj gen potencijalno učestvuje u embrionskom razvoju i diferencijaciji epitelnih ćelija.^[2]

Reference

[уреди |уреди извор]

^Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN (2000). „Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C)”.Genomics.67 (1): 8—18.PMID 10945465.doi:10.1006/geno.2000.6226.
^^а ^б„Entrez Gene: GPRC5C G protein-coupled receptor, family C, group 5, member C”.

Literatura

[уреди |уреди извор]

Maruyama K, Sugano S (1994). „Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides”.Gene.138 (1–2): 171—4.PMID 8125298.doi:10.1016/0378-1119(94)90802-8.
Suzuki Y, Yoshitomo-Nakagawa K, et al. (1997). „Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library”.Gene.200 (1–2): 149—56.PMID 9373149.doi:10.1016/S0378-1119(97)00411-3.
Bräuner-Osborne H, Krogsgaard-Larsen P (2000). „Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain”.Genomics.65 (2): 121—8.PMID 10783259.doi:10.1006/geno.2000.6164.
Bräuner-Osborne H, Jensen AA, et al. (2001). „Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D”.Biochim. Biophys. Acta.1518 (3): 237—48.PMID 11311935.
Strausberg RL, Feingold EA, et al. (2003).„Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”.Proc. Natl. Acad. Sci. U.S.A.99 (26): 16899—903.PMC 139241 .PMID 12477932.doi:10.1073/pnas.242603899.
Lehner B, Semple JI, et al. (2004). „Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region”.Genomics.83 (1): 153—67.PMID 14667819.doi:10.1016/S0888-7543(03)00235-0.
Ota T, Suzuki Y, et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs”.Nat. Genet.36 (1): 40—5.PMID 14702039.doi:10.1038/ng1285.
Gerhard DS, Wagner L, et al. (2004).„The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”.Genome Res.14 (10B): 2121—7.PMC 528928 .PMID 15489334.doi:10.1101/gr.2596504.
Rual JF, Venkatesan K, et al. (2005).„Towards a proteome-scale map of the human protein-protein interaction network”.Nature.437 (7062): 1173—8.PMID 16189514.doi:10.1038/nature04209.
Otsuki T, Ota T, et al. (2007). „Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries”.DNA Res.12 (2): 117—26.PMID 16303743.doi:10.1093/dnares/12.2.117.

Vidi još

[уреди |уреди извор]

Retinoinskom kiselinom inducibilni orfan G protein spregnuti receptori‎

Spoljašnje veze

[уреди |уреди извор]

„GPRC5 Receptors: RAIG₃”.IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано изоригинала 04. 03. 2016. г.

Transmembranski receptor:receptori spregnuti s G proteinom

Klasa A:Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A,B,D) • α2 (A,B,C) • β1 • β2 • β3
Purinski	Adenozinski (A1,A2A,A2B,A3) • P2Y (1,2,4,5,6,8,9,10,11,12,13,14)
Serotoninski	(svi osim 5-HT3)5-HT1 (A,B,D,E,F) • 5-HT2 (A,B,C) • 5-HT (4,5A,6,7)
Drugi	Acetilholin (M1,M2,M3,M4,M5) • Dopamin (D1,D2,D3,D4,D5) • Histamin (H1,H2,H3,H4) • Melatonin (1A,1B,1C) • TAAR (1,2,3,5,6,8,9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1,2) • LTB4 (1,2) • FPRL1 • OXE • Prostaglandin (DP (1,2),EP (1,2,3,4),FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1,CB2,GPR (18,55,119)) • EBI2 • Estrogen • Slobodna masna kiselina (1,2,3,4) • Laktat • Lizofosfatidna kiselina (1,2,3,4,5,6) • Lizofosfolipid (1,2,3,4,5,6,7,8) • Niacin (1,2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1,2,3,4,5) • Sukcinat

Peptid

Neuropeptidni

B/W (1,2) • FF (1,2) • S • Y (1,2,4,5) • Neuromedin (B,U (1,2)) • Neurotenzin (1,2)

Drugi

Anafilatoksin (C3a,C5a) • Angiotenzin (1,2) • Apelin • Bombezin (BRS3,GRPR,NMBR) • Bradikinin (B1,B2) • Hemokin • Holecistokinin (A,B) • Endotelin (A,B) • Formil peptid (1,2,3) • FSH • Galanin (1,2,3) • GHB receptor • Gonadotropin-oslobađajući hormon (1,2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1,1L,D,E,F,G,X1,X2,X3,X4) • Melanokortin (1,2,3,4,5) • MCHR (1,2) • Motilin • Opioidni (δ,κ,μ,Nociceptin &ζ, ali neσ) • Oreksin (1,2) • Oksitocin • Prokineticin (1,2) • Prolaktin-oslobađajući peptid • Relaksin (1,2,3,4) • Somatostatin (1,2,3,4,5) • Tahikinin (1,2,3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A,1B,2)

Razno

Orfan	GPR (1,3,4,6,12,15,17,18,19,20,21,22,23,25,26,27,31,32,33,34,35,37,39,42,44,45,50,52,55,61,62,63,65,68,75,77,78,81,82,83,84,85,87,88,92,101,103,109A,109B,119,120,132,135,137B,139,141,142,146,148,149,150,151,152,153,160,161,162,171,173,174,176,177,182,183)
Drugi	Adrenomedulin • Mirisni • Opsin (3,4,5,1LW,1MW,1SW,RGR,RRH) • Proteazom-aktivirani (1,2,3,4) • SREB (1,2,3)

Klasa B:Sekretinu slični

Orfan	GPR (56,64,97,98,110,111,112,113,114,115,116,123,124,125,126,128,133,143,144,155,157)
Drugi	Moždano specifični angiogenezni inhibitor (1,2,3) • Kadherin (1,2,3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1,2) • EMR (1,2,3) • Glukagon (GR,GIPR,GLP1R,GLP2R) • Hormon rasta • PACAPR1 • GPR • Latrofilin (1,2,3,ELTD1) • Metuzalemski protein • Paratiroidni hormon (1,2) • Sekretin • Vazoaktivni intestinalni peptid (1,2)

Klasa C:Metabotropni
glutamat /feromon

Ukus	TAS1R (1,2,3) • TAS2R (1,3,4,5,8,9,10,12,13,14,16,19,20,30,31,38,39,40,41,42,43,45,46,50)
Drugi	Kalcijum-detektujući receptor • GABA B (1,2) • Glutamatni receptor (Metabotropni glutamat (1,2,3,4,5,6,7,8)) • GPRC6A • GPR (156,158,179) • RAIG (1,2,3,4) • VNR (1,2,3,5)

Klasa F:
Frizzled /Zaglađeni

Uvojiti	Frizzled (1,2,3,4,5,6,7,8,9,10)
Zaglađeni	Zaglađeni

Преузето из „https://sr.wikipedia.org/w/index.php?title=GPRC5C&oldid=30644073”

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