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GPR61

Уреди везе

С Википедије, слободне енциклопедије

G protein-spregnuti receptor 61

Identifikatori

Simboli

GPR61; BALGR; GPCR3

Vanjski ID

OMIM: 606916MGI: 2441719HomoloGene: 12910IUPHAR:GPR61GeneCards:GPR61 Gene

Ontologija gena
Molekularna funkcija	•aktivnost rodopsinu sličnog receptora •receptorska aktivnost
Celularna komponenta	•integralno sa ćelijskom membranom •membrana •integralno sa membranom
Biološki proces	•prenos signala •signalni put G-protein spregnutog receptora •biološki_proces

Ortolozi

Vrsta

Čovek

Miš

RefSeq (mRNA)

RefSeq (protein)

Lokacija (UCSC)

Chr 1:
109.88 - 109.89 Mb

Chr 3:
108.28 - 108.28 Mb

PubMed pretraga

[1]

[2]

GPR61,G protein-spregnuti receptor 61, jeprotein koji je kod čoveka kodiranGPR61genom.^[1]^[2]^[3]

Ovaj gen pripada familijiG-protein spregnutih receptora. Oni sadrže sedamtransmembranskih domena i prenose ekstracelularne signale uz pomoćheterotrimernih G proteina. Protein kodiran ovim genom je blisko srodan receptorimabiogenih amina.^[3]

Literatura

[уреди |уреди извор]

^Lee DK, George SR, Cheng R, Nguyen T, Liu Y, Brown M, Lynch KR, O'Dowd BF (2001). „Identification of four novel human G protein-coupled receptors expressed in the brain”.Brain Res Mol Brain Res.86 (1–2): 13—22.PMID 11165367.doi:10.1016/S0169-328X(00)00242-4.
^Cikos S, Gregor P, Koppel J (2001). „Cloning of a novel biogenic amine receptor-like G protein-coupled receptor expressed in human brain”.Biochim Biophys Acta.1521 (1–3): 66—72.PMID 11690637.doi:10.1016/s0167-4781(01)00289-5.
^^а ^б„Entrez Gene: GPR61 G protein-coupled receptor 61”.

Dodatna literatura

[уреди |уреди извор]

Gregory SG; Barlow KF; McLay KE; et al. (2006). „The DNA sequence and biological annotation of human chromosome 1.”.Nature.441 (7091): 315—21.PMID 16710414.S2CID 4431933.doi:10.1038/nature04727.
Kimura K; Wakamatsu A; Suzuki Y; et al. (2006).„Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.”.Genome Res.16 (1): 55—65.PMC 1356129 .PMID 16344560.doi:10.1101/gr.4039406.
Conner AC; Hay DL; Simms J; et al. (2005). „A key role for transmembrane prolines in calcitonin receptor-like receptor agonist binding and signalling: implications for family B G-protein-coupled receptors.”.Mol. Pharmacol.67 (1): 20—31.PMID 15615699.doi:10.1124/mol.67.1.Проверите вредност параметра|doi= (помоћ).
Gerhard DS; Wagner L; Feingold EA; et al. (2004).„The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”.Genome Res.14 (10B): 2121—7.PMC 528928 .PMID 15489334.doi:10.1101/gr.2596504.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003).„Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”.Proc. Natl. Acad. Sci. U.S.A.99 (26): 16899—903.PMC 139241 .PMID 12477932.doi:10.1073/pnas.242603899 .
Takeda S; Kadowaki S; Haga T; et al. (2002). „Identification of G protein-coupled receptor genes from the human genome sequence.”.FEBS Lett.520 (1–3): 97—101.PMID 12044878.S2CID 7116392.doi:10.1016/S0014-5793(02)02775-8.

Spoljašnje veze

[уреди |уреди извор]

GPR61+receptor,+human наUS National Library of Medicine Medical Subject Headings (MeSH)

Transmembranski receptor:receptori spregnuti s G proteinom

Klasa A:Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A,B,D) • α2 (A,B,C) • β1 • β2 • β3
Purinski	Adenozinski (A1,A2A,A2B,A3) • P2Y (1,2,4,5,6,8,9,10,11,12,13,14)
Serotoninski	(svi osim 5-HT3)5-HT1 (A,B,D,E,F) • 5-HT2 (A,B,C) • 5-HT (4,5A,6,7)
Drugi	Acetilholin (M1,M2,M3,M4,M5) • Dopamin (D1,D2,D3,D4,D5) • Histamin (H1,H2,H3,H4) • Melatonin (1A,1B,1C) • TAAR (1,2,3,5,6,8,9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1,2) • LTB4 (1,2) • FPRL1 • OXE • Prostaglandin (DP (1,2),EP (1,2,3,4),FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1,CB2,GPR (18,55,119)) • EBI2 • Estrogen • Slobodna masna kiselina (1,2,3,4) • Laktat • Lizofosfatidna kiselina (1,2,3,4,5,6) • Lizofosfolipid (1,2,3,4,5,6,7,8) • Niacin (1,2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1,2,3,4,5) • Sukcinat

Peptid

Neuropeptidni

B/W (1,2) • FF (1,2) • S • Y (1,2,4,5) • Neuromedin (B,U (1,2)) • Neurotenzin (1,2)

Drugi

Anafilatoksin (C3a,C5a) • Angiotenzin (1,2) • Apelin • Bombezin (BRS3,GRPR,NMBR) • Bradikinin (B1,B2) • Hemokin • Holecistokinin (A,B) • Endotelin (A,B) • Formil peptid (1,2,3) • FSH • Galanin (1,2,3) • GHB receptor • Gonadotropin-oslobađajući hormon (1,2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1,1L,D,E,F,G,X1,X2,X3,X4) • Melanokortin (1,2,3,4,5) • MCHR (1,2) • Motilin • Opioidni (δ,κ,μ,Nociceptin &ζ, ali neσ) • Oreksin (1,2) • Oksitocin • Prokineticin (1,2) • Prolaktin-oslobađajući peptid • Relaksin (1,2,3,4) • Somatostatin (1,2,3,4,5) • Tahikinin (1,2,3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A,1B,2)

Razno

Orfan	GPR (1,3,4,6,12,15,17,18,19,20,21,22,23,25,26,27,31,32,33,34,35,37,39,42,44,45,50,52,55,61,62,63,65,68,75,77,78,81,82,83,84,85,87,88,92,101,103,109A,109B,119,120,132,135,137B,139,141,142,146,148,149,150,151,152,153,160,161,162,171,173,174,176,177,182,183)
Drugi	Adrenomedulin • Mirisni • Opsin (3,4,5,1LW,1MW,1SW,RGR,RRH) • Proteazom-aktivirani (1,2,3,4) • SREB (1,2,3)

Klasa B:Sekretinu slični

Orfan	GPR (56,64,97,98,110,111,112,113,114,115,116,123,124,125,126,128,133,143,144,155,157)
Drugi	Moždano specifični angiogenezni inhibitor (1,2,3) • Kadherin (1,2,3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1,2) • EMR (1,2,3) • Glukagon (GR,GIPR,GLP1R,GLP2R) • Hormon rasta • PACAPR1 • GPR • Latrofilin (1,2,3,ELTD1) • Metuzalemski protein • Paratiroidni hormon (1,2) • Sekretin • Vazoaktivni intestinalni peptid (1,2)

Klasa C:Metabotropni
glutamat /feromon

Ukus	TAS1R (1,2,3) • TAS2R (1,3,4,5,8,9,10,12,13,14,16,19,20,30,31,38,39,40,41,42,43,45,46,50)
Drugi	Kalcijum-detektujući receptor • GABA B (1,2) • Glutamatni receptor (Metabotropni glutamat (1,2,3,4,5,6,7,8)) • GPRC6A • GPR (156,158,179) • RAIG (1,2,3,4) • VNR (1,2,3,5)

Klasa F:
Frizzled /Zaglađeni

Uvojiti	Frizzled (1,2,3,4,5,6,7,8,9,10)
Zaglađeni	Zaglađeni

Преузето из „https://sr.wikipedia.org/w/index.php?title=GPR61&oldid=27557692”

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CS1 грешке: DOI

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