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GPR124

Уреди везе

С Википедије, слободне енциклопедије

G protein spregnuti receptor 124

Identifikatori

Simboli

GPR124; TEM5

Vanjski ID

OMIM: 606823MGI: 1925810HomoloGene: 13112IUPHAR:GPR124GeneCards:GPR124 Gene

Ontologija gena
Molekularna funkcija	•aktivnost G protein spregnutog receptora
Celularna komponenta	•integralno sa ćelijskom membranom •integralno sa membranom
Biološki proces	•ćelijska adhezija •signalni put G protein spregnutog receptora •neuropeptidni signalni put •razvoj centralnog nervnog sistema •endotelna ćelijska migracija •regulacija angiogeneze •regulacija hemotakse

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

RefSeq (mRNA)

RefSeq (protein)

Lokacija (UCSC)

Chr 8:
37.64 - 37.7 Mb

Chr 8:
28.2 - 28.23 Mb

PubMed pretraga

[1]

[2]

G protein spregnuti receptor 124 jeprotein koji je kod ljudi kodiranGPR124genom.^[1]^[2]^[3]

Interakcije

[уреди |уреди извор]

GPR124 formira interakcije sainteract saDLG1.^[4]

Reference

[уреди |уреди извор]

^Carson-Walter EB, Watkins DN, Nanda A, Vogelstein B, Kinzler KW, St Croix B (septembar 2001).„Cell surface tumor endothelial markers are conserved in mice and humans”.Cancer Res.61 (18): 6649—55.PMID 11559528.
^Fredriksson R, Gloriam DE, Hoglund PJ, Lagerstrom MC, Schioth HB (februar 2003). „There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini”.Biochem Biophys Res Commun.301 (3): 725—34.PMID 12565841.doi:10.1016/S0006-291X(03)00026-3.
^„Entrez Gene: GPR124 G protein-coupled receptor 124”.
^Yamamoto, Yasunori; Irie Kenji; et al. (maj 2004). „Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein”.Oncogene. England.23 (22): 3889—97.ISSN 0950-9232.PMID 15021905.doi:10.1038/sj.onc.1207495.

Literatura

[уреди |уреди извор]

Nakajima D; Okazaki N; Yamakawa H; et al. (2003). „Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.”.DNA Res.9 (3): 99—106.PMID 12168954.doi:10.1093/dnares/9.3.99.
Nagase T; Kikuno R; Ishikawa K; et al. (2000). „Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.”.DNA Res.7 (2): 143—50.PMID 10819331.doi:10.1093/dnares/7.2.143.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003).„Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”.Proc. Natl. Acad. Sci. U.S.A.99 (26): 16899—903.PMC 139241 .PMID 12477932.doi:10.1073/pnas.242603899.
Ota T; Suzuki Y; Nishikawa T; et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs.”.Nat. Genet.36 (1): 40—5.PMID 14702039.doi:10.1038/ng1285.
Yamamoto Y; Irie K; Asada M; et al. (2004). „Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein.”.Oncogene.23 (22): 3889—97.PMID 15021905.doi:10.1038/sj.onc.1207495.
Bjarnadóttir TK; Fredriksson R; Höglund PJ; et al. (2005). „The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.”.Genomics.84 (1): 23—33.PMID 15203201.doi:10.1016/j.ygeno.2003.12.004.
Vallon M, Essler M (2006).„Proteolytically processed soluble tumor endothelial marker (TEM) 5 mediates endothelial cell survival during angiogenesis by linking integrin alpha(v)beta3 to glycosaminoglycans.”.J. Biol. Chem.281 (45): 34179—88.PMID 16982628.doi:10.1074/jbc.M605291200.

Transmembranski receptor:receptori spregnuti s G proteinom

Klasa A:Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A,B,D) • α2 (A,B,C) • β1 • β2 • β3
Purinski	Adenozinski (A1,A2A,A2B,A3) • P2Y (1,2,4,5,6,8,9,10,11,12,13,14)
Serotoninski	(svi osim 5-HT3)5-HT1 (A,B,D,E,F) • 5-HT2 (A,B,C) • 5-HT (4,5A,6,7)
Drugi	Acetilholin (M1,M2,M3,M4,M5) • Dopamin (D1,D2,D3,D4,D5) • Histamin (H1,H2,H3,H4) • Melatonin (1A,1B,1C) • TAAR (1,2,3,5,6,8,9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1,2) • LTB4 (1,2) • FPRL1 • OXE • Prostaglandin (DP (1,2),EP (1,2,3,4),FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1,CB2,GPR (18,55,119)) • EBI2 • Estrogen • Slobodna masna kiselina (1,2,3,4) • Laktat • Lizofosfatidna kiselina (1,2,3,4,5,6) • Lizofosfolipid (1,2,3,4,5,6,7,8) • Niacin (1,2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1,2,3,4,5) • Sukcinat

Peptid

Neuropeptidni

B/W (1,2) • FF (1,2) • S • Y (1,2,4,5) • Neuromedin (B,U (1,2)) • Neurotenzin (1,2)

Drugi

Anafilatoksin (C3a,C5a) • Angiotenzin (1,2) • Apelin • Bombezin (BRS3,GRPR,NMBR) • Bradikinin (B1,B2) • Hemokin • Holecistokinin (A,B) • Endotelin (A,B) • Formil peptid (1,2,3) • FSH • Galanin (1,2,3) • GHB receptor • Gonadotropin-oslobađajući hormon (1,2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1,1L,D,E,F,G,X1,X2,X3,X4) • Melanokortin (1,2,3,4,5) • MCHR (1,2) • Motilin • Opioidni (δ,κ,μ,Nociceptin &ζ, ali neσ) • Oreksin (1,2) • Oksitocin • Prokineticin (1,2) • Prolaktin-oslobađajući peptid • Relaksin (1,2,3,4) • Somatostatin (1,2,3,4,5) • Tahikinin (1,2,3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A,1B,2)

Razno

Orfan	GPR (1,3,4,6,12,15,17,18,19,20,21,22,23,25,26,27,31,32,33,34,35,37,39,42,44,45,50,52,55,61,62,63,65,68,75,77,78,81,82,83,84,85,87,88,92,101,103,109A,109B,119,120,132,135,137B,139,141,142,146,148,149,150,151,152,153,160,161,162,171,173,174,176,177,182,183)
Drugi	Adrenomedulin • Mirisni • Opsin (3,4,5,1LW,1MW,1SW,RGR,RRH) • Proteazom-aktivirani (1,2,3,4) • SREB (1,2,3)

Klasa B:Sekretinu slični

Orfan	GPR (56,64,97,98,110,111,112,113,114,115,116,123,124,125,126,128,133,143,144,155,157)
Drugi	Moždano specifični angiogenezni inhibitor (1,2,3) • Kadherin (1,2,3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1,2) • EMR (1,2,3) • Glukagon (GR,GIPR,GLP1R,GLP2R) • Hormon rasta • PACAPR1 • GPR • Latrofilin (1,2,3,ELTD1) • Metuzalemski protein • Paratiroidni hormon (1,2) • Sekretin • Vazoaktivni intestinalni peptid (1,2)

Klasa C:Metabotropni
glutamat /feromon

Ukus	TAS1R (1,2,3) • TAS2R (1,3,4,5,8,9,10,12,13,14,16,19,20,30,31,38,39,40,41,42,43,45,46,50)
Drugi	Kalcijum-detektujući receptor • GABA B (1,2) • Glutamatni receptor (Metabotropni glutamat (1,2,3,4,5,6,7,8)) • GPRC6A • GPR (156,158,179) • RAIG (1,2,3,4) • VNR (1,2,3,5)

Klasa F:
Frizzled /Zaglađeni

Uvojiti	Frizzled (1,2,3,4,5,6,7,8,9,10)
Zaglađeni	Zaglađeni

Преузето из „https://sr.wikipedia.org/w/index.php?title=GPR124&oldid=30643984”

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