GNAQ,Guanin nukleotid-vezujući protein G(q), podjedinica alfa, jeprotein koji je kod ljudi kodiranGNAQgenom.[1]
Guanin nukleotid-vezujući proteini su familija heterotrimernih proteina koji se uparuju sa proteinima ćelijske površine, 7-TM domenskim receptorima, i posreduju intracelularnu signalizaciju. Aktivacija receptorakatalizuje izmenuGDP zaGTP. GDP je vezan za neaktivnuG protein alfa podedinicu. Vezivanjeagonista dovodi do konformacione promene i disocijacije kompleksa. G protein alfa i beta-gama podjedinice imaju sposobnost regulacije niza celularnih efektora. Aktivacija se okončava GTPazom specifičnom za G-alfa podjedinicu. G-alfa-q podjedinica je jedan od heterotrimernih GTP-vezujućih proteina koji posreduje stimulaciju fosfolipaze C-beta (MIM 600230).[2]
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