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GABBR2

Уреди везе

С Википедије, слободне енциклопедије

Receptor 2 gama-aminobuterne kiseline B

Identifikatori

Simboli

GABBR2; GABABR2; GPR51; GPRC3B; HG20; HRIHFB2099

Vanjski ID

OMIM: 607340MGI: 2386030HomoloGene: 55902IUPHAR:GABA_B2GeneCards:GABBR2 Gene

Ontologija gena
Molekularna funkcija	•aktivnost prenosnika signala •receptorska aktivnost •aktivnost G-protein spregnutog GABA receptora
Celularna komponenta	•citoplazma •ćelijska membrana •integralno sa ćelijskom membranom •ćelijski spoj •neuronska projekcija •sinapsa •postsinaptička membrana
Biološki proces	•signalni put G-protein spregnutog receptora •negativna regulacija aktivnosti adenilat ciklaze •signalni put gama-aminobuterne kiseline •sinaptička transmisija

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

RefSeq (mRNA)

RefSeq (protein)

Lokacija (UCSC)

Chr 9:
101.05 - 101.47 Mb

Chr 4:
46.68 - 47 Mb

PubMed pretraga

[1]

[2]

Receptor 2 gama-aminobuterne kiseline B (GABA_B1) je podjedinicaG protein spregnutog receptora koja je kod ljudi kodiranaGABBR2genom.^[1]

B-tip receptora zaneurotransmiter GABA (gama-aminobuterna kiselina) inhibira neuronsku aktivnost putem G protein spregnutog sistema sekundarnih glasnika, koji reguliše oslobađanje neurotransmiter, aktivnost jonskih kanala iadenilil ciklaze.^[1]

Interakcije

[уреди |уреди извор]

Poznato je da GABBR2 formirainterakcije saGABBR1.^[2]

Vidi još

[уреди |уреди извор]

GABAB receptor

Reference

[уреди |уреди извор]

^^а ^б„Entrez Gene: GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2”.
^White JH, Wise A, Main MJ, Green A, Fraser NJ, Disney GH, Barnes AA, Emson P, Foord SM, Marshall FH (1998).„Heterodimerization is required for the formation of a functional GABA(B) receptor”.Nature. ENGLAND.396 (6712): 679—82.ISSN 0028-0836.PMID 9872316.doi:10.1038/25354.

Literatura

[уреди |уреди извор]

White JH; Wise A; Main MJ; et al. (1999). „Heterodimerization is required for the formation of a functional GABA(B) receptor”.Nature.396 (6712): 679—82.PMID 9872316.doi:10.1038/25354.
Ng GY; Clark J; Coulombe N; et al. (1999).„Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity”.J. Biol. Chem.274 (12): 7607—10.PMID 10075644.doi:10.1074/jbc.274.12.7607.
Ng GY; McDonald T; Bonnert T; et al. (1999). „Cloning of a novel G-protein-coupled receptor GPR 51 resembling GABAB receptors expressed predominantly in nervous tissues and mapped proximal to the hereditary sensory neuropathy type 1 locus on chromosome 9”.Genomics.56 (3): 288—95.PMID 10087195.doi:10.1006/geno.1998.5706.
Martin SC, Russek SJ, Farb DH (1999). „Molecular identification of the human GABABR2: cell surface expression and coupling to adenylyl cyclase in the absence of GABABR1”.Mol. Cell. Neurosci.13 (3): 180—91.PMID 10328880.doi:10.1006/mcne.1999.0741.
Clark JA, Mezey E, Lam AS, Bonner TI (2000). „Distribution of the GABA(B) receptor subunit gb2 in rat CNS”.Brain Res.860 (1–2): 41—52.PMID 10727622.doi:10.1016/S0006-8993(00)01958-2.
Sullivan R; Chateauneuf A; Coulombe N; et al. (2000). „Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor”.J. Pharmacol. Exp. Ther.293 (2): 460—7.PMID 10773016.
White JH; McIllhinney RA; Wise A; et al. (2001).„The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx”.Proc. Natl. Acad. Sci. U.S.A.97 (25): 13967—72.PMC 17684 .PMID 11087824.doi:10.1073/pnas.240452197.
Kitano J; Kimura K; Yamazaki Y; et al. (2002). „Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins”.J. Neurosci.22 (4): 1280—9.PMID 11850456.
Salim K; Fenton T; Bacha J; et al. (2002).„Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation”.J. Biol. Chem.277 (18): 15482—5.PMID 11854302.doi:10.1074/jbc.M201539200.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003).„Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”.Proc. Natl. Acad. Sci. U.S.A.99 (26): 16899—903.PMC 139241 .PMID 12477932.doi:10.1073/pnas.242603899.
Furtinger S; Pirker S; Czech T; et al. (2004). „Increased expression of gamma-aminobutyric acid type B receptors in the hippocampus of patients with temporal lobe epilepsy”.Neurosci. Lett.352 (2): 141—5.PMID 14625043.doi:10.1016/j.neulet.2003.08.046.
Waldvogel HJ; Billinton A; White JH; et al. (2004). „Comparative cellular distribution of GABAA and GABAB receptors in the human basal ganglia: immunohistochemical colocalization of the alpha 1 subunit of the GABAA receptor, and the GABABR1 and GABABR2 receptor subunits”.J. Comp. Neurol.470 (4): 339—56.PMID 14961561.doi:10.1002/cne.20005.
Balasubramanian S, Teissére JA, Raju DV, Hall RA (2004).„Hetero-oligomerization between GABAA and GABAB receptors regulates GABAB receptor trafficking”.J. Biol. Chem.279 (18): 18840—50.PMID 14966130.doi:10.1074/jbc.M313470200.
Uezono Y; Kaibara M; Hayashi H; et al. (2004). „Characterization of GABAB receptor in the human colon”.J. Pharmacol. Sci.94 (2): 211—3.PMID 14978362.doi:10.1254/jphs.94.211.
Humphray SJ; Oliver K; Hunt AR; et al. (2004).„DNA sequence and analysis of human chromosome 9”.Nature.429 (6990): 369—74.PMC 2734081 .PMID 15164053.doi:10.1038/nature02465.
Gerhard DS; Wagner L; Feingold EA; et al. (2004).„The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”.Genome Res.14 (10B): 2121—7.PMC 528928 .PMID 15489334.doi:10.1101/gr.2596504.
Hlavackova V; Goudet C; Kniazeff J; et al. (2005).„Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR”.EMBO J.24 (3): 499—509.PMC 548662 .PMID 15660124.doi:10.1038/sj.emboj.7600557.
DeGiorgis JA; Jaffe H; Moreira JE; et al. (2005). „Phosphoproteomic analysis of synaptosomes from human cerebral cortex”.J. Proteome Res.4 (2): 306—15.PMID 15822905.doi:10.1021/pr0498436.
Rual JF; Venkatesan K; Hao T; et al. (2005).„Towards a proteome-scale map of the human protein-protein interaction network”.Nature.437 (7062): 1173—8.PMID 16189514.doi:10.1038/nature04209.
Osawa Y; Xu D; Sternberg D; et al. (2006). „Functional expression of the GABAB receptor in human airway smooth muscle”.Am. J. Physiol. Lung Cell Mol. Physiol.291 (5): L923—31.PMID 16829628.doi:10.1152/ajplung.00185.2006.

Spoljašnje veze

[уреди |уреди извор]

„GABA_B Receptors: GABA_B2”.IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано изоригинала 08. 08. 2014. г.

Transmembranski receptor:receptori spregnuti s G proteinom

Klasa A:Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A,B,D) • α2 (A,B,C) • β1 • β2 • β3
Purinski	Adenozinski (A1,A2A,A2B,A3) • P2Y (1,2,4,5,6,8,9,10,11,12,13,14)
Serotoninski	(svi osim 5-HT3)5-HT1 (A,B,D,E,F) • 5-HT2 (A,B,C) • 5-HT (4,5A,6,7)
Drugi	Acetilholin (M1,M2,M3,M4,M5) • Dopamin (D1,D2,D3,D4,D5) • Histamin (H1,H2,H3,H4) • Melatonin (1A,1B,1C) • TAAR (1,2,3,5,6,8,9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1,2) • LTB4 (1,2) • FPRL1 • OXE • Prostaglandin (DP (1,2),EP (1,2,3,4),FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1,CB2,GPR (18,55,119)) • EBI2 • Estrogen • Slobodna masna kiselina (1,2,3,4) • Laktat • Lizofosfatidna kiselina (1,2,3,4,5,6) • Lizofosfolipid (1,2,3,4,5,6,7,8) • Niacin (1,2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1,2,3,4,5) • Sukcinat

Peptid

Neuropeptidni

B/W (1,2) • FF (1,2) • S • Y (1,2,4,5) • Neuromedin (B,U (1,2)) • Neurotenzin (1,2)

Drugi

Anafilatoksin (C3a,C5a) • Angiotenzin (1,2) • Apelin • Bombezin (BRS3,GRPR,NMBR) • Bradikinin (B1,B2) • Hemokin • Holecistokinin (A,B) • Endotelin (A,B) • Formil peptid (1,2,3) • FSH • Galanin (1,2,3) • GHB receptor • Gonadotropin-oslobađajući hormon (1,2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1,1L,D,E,F,G,X1,X2,X3,X4) • Melanokortin (1,2,3,4,5) • MCHR (1,2) • Motilin • Opioidni (δ,κ,μ,Nociceptin &ζ, ali neσ) • Oreksin (1,2) • Oksitocin • Prokineticin (1,2) • Prolaktin-oslobađajući peptid • Relaksin (1,2,3,4) • Somatostatin (1,2,3,4,5) • Tahikinin (1,2,3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A,1B,2)

Razno

Orfan	GPR (1,3,4,6,12,15,17,18,19,20,21,22,23,25,26,27,31,32,33,34,35,37,39,42,44,45,50,52,55,61,62,63,65,68,75,77,78,81,82,83,84,85,87,88,92,101,103,109A,109B,119,120,132,135,137B,139,141,142,146,148,149,150,151,152,153,160,161,162,171,173,174,176,177,182,183)
Drugi	Adrenomedulin • Mirisni • Opsin (3,4,5,1LW,1MW,1SW,RGR,RRH) • Proteazom-aktivirani (1,2,3,4) • SREB (1,2,3)

Klasa B:Sekretinu slični

Orfan	GPR (56,64,97,98,110,111,112,113,114,115,116,123,124,125,126,128,133,143,144,155,157)
Drugi	Moždano specifični angiogenezni inhibitor (1,2,3) • Kadherin (1,2,3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1,2) • EMR (1,2,3) • Glukagon (GR,GIPR,GLP1R,GLP2R) • Hormon rasta • PACAPR1 • GPR • Latrofilin (1,2,3,ELTD1) • Metuzalemski protein • Paratiroidni hormon (1,2) • Sekretin • Vazoaktivni intestinalni peptid (1,2)

Klasa C:Metabotropni
glutamat /feromon

Ukus	TAS1R (1,2,3) • TAS2R (1,3,4,5,8,9,10,12,13,14,16,19,20,30,31,38,39,40,41,42,43,45,46,50)
Drugi	Kalcijum-detektujući receptor • GABA B (1,2) • Glutamatni receptor (Metabotropni glutamat (1,2,3,4,5,6,7,8)) • GPRC6A • GPR (156,158,179) • RAIG (1,2,3,4) • VNR (1,2,3,5)

Klasa F:
Frizzled /Zaglađeni

Uvojiti	Frizzled (1,2,3,4,5,6,7,8,9,10)
Zaglađeni	Zaglađeni

Преузето из „https://sr.wikipedia.org/w/index.php?title=GABBR2&oldid=30642201”

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