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FZD7

Уреди везе

С Википедије, слободне енциклопедије

Uvojiti receptor 7

Identifikatori

Simboli

FZD7; FzE3

Vanjski ID

OMIM: 603410MGI: 108570HomoloGene: 20751IUPHAR:FZD₇GeneCards:FZD7 Gene

Ontologija gena
Molekularna funkcija	•aktivnost G protein spregnutog receptora •receptorsko vezivanje •proteinsko vezivanje •Wnt proteinsko vezivanje •vezivanje PDZ domena
Celularna komponenta	•citoplazma •ćelijska površina •integralno sa membranom •sinaptosom •membrana neuronske projekcije
Biološki proces	•pozitivna regulacija proteinske fosforilacije •razvoj vaskulature •morfogeneza odlivnog trakta •signalni put G protein spregnutog receptora spregnutog sa cGMP nukleotidom

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

RefSeq (mRNA)

RefSeq (protein)

Lokacija (UCSC)

Chr 2:
202.9 - 202.9 Mb

Chr 1:
59.54 - 59.54 Mb

PubMed pretraga

[1]

[2]

Uvojiti-7 jeprotein koji je kod ljudi kodiranFZD7genom.^[1]^[2]^[3]

Članovi familije „uvojitih“ proteina su 7-transmembranski receptori za Wnt signalne proteine. FZD7 protein sadrži signalni peptid,cisteinom bogati domen uN-terminalnom ekstracelularnom regionu, 7 transmembranski domen, iC-terminalni PDZ vezujući motiv. Izražavanje FZD7 gena može da umanji APC funkciju i pojača beta-katenin-posredovane signale u slabo diferenciranom ljudskimkarcinomima jednjaka.^[3]

Interakcije

[уреди |уреди извор]

FZD7 formirainterakcije saDLG4.^[4]

Reference

[уреди |уреди извор]

^Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K (1998).„A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals”.Proc Natl Acad Sci U S A.95 (17): 10164—9.PMC 21479 .PMID 9707618.doi:10.1073/pnas.95.17.10164.
^Sagara N, Toda G, Hirai M, Terada M, Katoh M (1998). „Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7”.Biochem Biophys Res Commun.252 (1): 117—22.PMID 9813155.doi:10.1006/bbrc.1998.9607.
^^а ^б„Entrez Gene: FZD7 frizzled homolog 7 (Drosophila)”.
^Hering, Heike; Sheng Morgan (2002). „Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95”.FEBS Lett. Netherlands.521 (1–3): 185—9.ISSN 0014-5793.PMID 12067714.doi:10.1016/S0014-5793(02)02831-4.

Literatura

[уреди |уреди извор]

Finch PW; He X; Kelley MJ (1997).„Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action”.Proc. Natl. Acad. Sci. U.S.A.94 (13): 6770—5.PMC 21233 .PMID 9192640.doi:10.1073/pnas.94.13.6770.
Hering H, Sheng M (2002). „Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95”.FEBS Lett.521 (1–3): 185—9.PMID 12067714.doi:10.1016/S0014-5793(02)02831-4.
Strausberg RL; Feingold EA; Grouse LH (2003).„Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”.Proc. Natl. Acad. Sci. U.S.A.99 (26): 16899—903.PMC 139241 .PMID 12477932.doi:10.1073/pnas.242603899.
Yao R, Natsume Y, Noda T (2005). „MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap”.Oncogene.23 (36): 6023—30.PMID 15195140.doi:10.1038/sj.onc.1207817.
Omoto S; Hayashi T; Kitahara K (2004). „Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)”.Ophthalmic Genet.25 (2): 81—90.PMID 15370539.doi:10.1080/13816810490514270.
Gerhard DS; Wagner L; Feingold EA (2004).„The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”.Genome Res.14 (10B): 2121—7.PMC 528928 .PMID 15489334.doi:10.1101/gr.2596504.
Vincan E; Darcy PK; Smyth MJ (2005). „Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth”.Differentiation.73 (4): 142—53.PMID 15901282.doi:10.1111/j.1432-0436.2005.00015.x.
Rual JF; Venkatesan K; Hao T (2005).„Towards a proteome-scale map of the human protein-protein interaction network”.Nature.437 (7062): 1173—8.PMID 16189514.doi:10.1038/nature04209.
Lim J; Hao T; Shaw C (2006). „A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration”.Cell.125 (4): 801—14.PMID 16713569.doi:10.1016/j.cell.2006.03.032.
Vincan E; Darcy PK; Farrelly CA (2007). „Frizzled-7 dictates three-dimensional organization of colorectal cancer cell carcinoids”.Oncogene.26 (16): 2340—52.PMID 17016432.doi:10.1038/sj.onc.1210026.
Struewing IT; Barnett CD; Zhang W (2007). „Frizzled-7 turnover at the plasma membrane is regulated by cell density and the Ca(2+) -dependent protease calpain-1”.Exp. Cell Res.313 (16): 3526—41.PMID 17716656.doi:10.1016/j.yexcr.2007.07.012.

Vidi još

[уреди |уреди извор]

Uvojiti receptori

Spoljašnje veze

[уреди |уреди извор]

„Frizzled Receptors: FZD₇”.IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано изоригинала 03. 03. 2016. г.

Transmembranski receptor:receptori spregnuti s G proteinom

Klasa A:Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A,B,D) • α2 (A,B,C) • β1 • β2 • β3
Purinski	Adenozinski (A1,A2A,A2B,A3) • P2Y (1,2,4,5,6,8,9,10,11,12,13,14)
Serotoninski	(svi osim 5-HT3)5-HT1 (A,B,D,E,F) • 5-HT2 (A,B,C) • 5-HT (4,5A,6,7)
Drugi	Acetilholin (M1,M2,M3,M4,M5) • Dopamin (D1,D2,D3,D4,D5) • Histamin (H1,H2,H3,H4) • Melatonin (1A,1B,1C) • TAAR (1,2,3,5,6,8,9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1,2) • LTB4 (1,2) • FPRL1 • OXE • Prostaglandin (DP (1,2),EP (1,2,3,4),FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1,CB2,GPR (18,55,119)) • EBI2 • Estrogen • Slobodna masna kiselina (1,2,3,4) • Laktat • Lizofosfatidna kiselina (1,2,3,4,5,6) • Lizofosfolipid (1,2,3,4,5,6,7,8) • Niacin (1,2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1,2,3,4,5) • Sukcinat

Peptid

Neuropeptidni

B/W (1,2) • FF (1,2) • S • Y (1,2,4,5) • Neuromedin (B,U (1,2)) • Neurotenzin (1,2)

Drugi

Anafilatoksin (C3a,C5a) • Angiotenzin (1,2) • Apelin • Bombezin (BRS3,GRPR,NMBR) • Bradikinin (B1,B2) • Hemokin • Holecistokinin (A,B) • Endotelin (A,B) • Formil peptid (1,2,3) • FSH • Galanin (1,2,3) • GHB receptor • Gonadotropin-oslobađajući hormon (1,2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1,1L,D,E,F,G,X1,X2,X3,X4) • Melanokortin (1,2,3,4,5) • MCHR (1,2) • Motilin • Opioidni (δ,κ,μ,Nociceptin &ζ, ali neσ) • Oreksin (1,2) • Oksitocin • Prokineticin (1,2) • Prolaktin-oslobađajući peptid • Relaksin (1,2,3,4) • Somatostatin (1,2,3,4,5) • Tahikinin (1,2,3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A,1B,2)

Razno

Orfan	GPR (1,3,4,6,12,15,17,18,19,20,21,22,23,25,26,27,31,32,33,34,35,37,39,42,44,45,50,52,55,61,62,63,65,68,75,77,78,81,82,83,84,85,87,88,92,101,103,109A,109B,119,120,132,135,137B,139,141,142,146,148,149,150,151,152,153,160,161,162,171,173,174,176,177,182,183)
Drugi	Adrenomedulin • Mirisni • Opsin (3,4,5,1LW,1MW,1SW,RGR,RRH) • Proteazom-aktivirani (1,2,3,4) • SREB (1,2,3)

Klasa B:Sekretinu slični

Orfan	GPR (56,64,97,98,110,111,112,113,114,115,116,123,124,125,126,128,133,143,144,155,157)
Drugi	Moždano specifični angiogenezni inhibitor (1,2,3) • Kadherin (1,2,3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1,2) • EMR (1,2,3) • Glukagon (GR,GIPR,GLP1R,GLP2R) • Hormon rasta • PACAPR1 • GPR • Latrofilin (1,2,3,ELTD1) • Metuzalemski protein • Paratiroidni hormon (1,2) • Sekretin • Vazoaktivni intestinalni peptid (1,2)

Klasa C:Metabotropni
glutamat /feromon

Ukus	TAS1R (1,2,3) • TAS2R (1,3,4,5,8,9,10,12,13,14,16,19,20,30,31,38,39,40,41,42,43,45,46,50)
Drugi	Kalcijum-detektujući receptor • GABA B (1,2) • Glutamatni receptor (Metabotropni glutamat (1,2,3,4,5,6,7,8)) • GPRC6A • GPR (156,158,179) • RAIG (1,2,3,4) • VNR (1,2,3,5)

Klasa F:
Frizzled /Zaglađeni

Uvojiti	Frizzled (1,2,3,4,5,6,7,8,9,10)
Zaglađeni	Zaglađeni

Преузето из „https://sr.wikipedia.org/w/index.php?title=FZD7&oldid=30642178”

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