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FZD6

Уреди везе

С Википедије, слободне енциклопедије

Uvojiti receptor 6

Identifikatori

Simboli

FZD6; FZ-6; FZ6; HFZ6; NDNC10

Vanjski ID

OMIM: 603409MGI: 108474HomoloGene: 2617IUPHAR:FZD₆GeneCards:FZD6 Gene

Ontologija gena
Molekularna funkcija	•aktivnost G protein spregnutog receptora •receptorsko vezivanje •proteinsko vezivanje •Wnt proteinsko vezivanje
Celularna komponenta	•citoplazma •ćelijska površina •integralno sa membranom •sinaptosom •membrana neuronske projekcije
Biološki proces	•pozitivna regulacija proteinske fosforilacije •razvoj vaskulature •morfogeneza odlivnog trakta •signalni put G protein spregnutog receptora spregnutog sa cGMP nukleotidom

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

RefSeq (mRNA)

RefSeq (protein)

Lokacija (UCSC)

Chr 8:
104.31 - 104.35 Mb

Chr 15:
38.84 - 38.87 Mb

PubMed pretraga

[1]

[2]

Uvojiti-6 jeprotein koji je kod ljudi kodiranFZD6genom.^[1]^[2]^[3]

Članovi familije „uvojitih“ proteina su 7-transmembranski receptori za Wnt signalne proteine. FZD6 protein sadrži signalni peptid,cisteinom bogati domen uN-terminalnom ekstracelularnom regionu i 7 transmembranski domen. Za razliku od mnogih drugih članova FZD familije, FDZ6 ne sadrži C-terminalni PDZ vezujući motif.^[3] Postoje indikacije da je FZD6 protein receptor za WNT4 ligand.^[4]

Interakcije

[уреди |уреди извор]

FZD6 formirainterakcije saSFRP1.^[5]

Reference

[уреди |уреди извор]

^Tokuhara M, Hirai M, Atomi Y, Terada M, Katoh M (1998). „Molecular cloning of human Frizzled-6”.Biochem Biophys Res Commun.243 (2): 622—7.PMID 9480858.doi:10.1006/bbrc.1998.8143.
^Golan T, Yaniv A, Bafico A, Liu G, Gazit A (2004). „The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade”.J Biol Chem.279 (15): 14879—88.PMID 14747478.doi:10.1074/jbc.M306421200.
^^а ^б„Entrez Gene: FZD6 frizzled homolog 6 (Drosophila)”.
^Lyons JP, Mueller UW, Ji H, Everett C, Fang X, Hsieh JC, Barth AM, McCrea PD (2004). „WNT4 activates the canonical beta-catenin-mediated WNT pathway and binds FZD6 CRD: functional implications of Wnt/beta-catenin activity in kidney epithelial cells.”.Experimental Cell Research.298 (2): 369—387.PMID 15265686.doi:10.1016/j.yexcr.2004.04.036.
^Bafico, A; Gazit A (1999). „Interaction of frizzled related protein (FRP) with WNT ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of WNT signaling”.J. Biol. Chem. UNITED STATES.274 (23): 16180—7.ISSN 0021-9258.PMID 10347172.doi:10.1074/jbc.274.23.16180.

Literatura

[уреди |уреди извор]

Wang Y; Macke JP; Abella BS (1996). „A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled.”.J. Biol. Chem.271 (8): 4468—76.PMID 8626800.doi:10.1074/jbc.271.8.4468.
Finch PW; He X; Kelley MJ (1997).„Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.”.Proc. Natl. Acad. Sci. U.S.A.94 (13): 6770—5.PMC 21233 .PMID 9192640.doi:10.1073/pnas.94.13.6770.
Bafico A; Gazit A; Pramila T (1999). „Interaction of frizzled related protein (FRP) with WNT ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling.”.J. Biol. Chem.274 (23): 16180—7.PMID 10347172.doi:10.1074/jbc.274.23.16180.
Strausberg RL; Feingold EA; Grouse LH (2003).„Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”.Proc. Natl. Acad. Sci. U.S.A.99 (26): 16899—903.PMC 139241 .PMID 12477932.doi:10.1073/pnas.242603899.
Omoto S; Hayashi T; Kitahara K (2004). „Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R).”.Ophthalmic Genet.25 (2): 81—90.PMID 15370539.doi:10.1080/13816810490514270.
Gerhard DS; Wagner L; Feingold EA (2004).„The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”.Genome Res.14 (10B): 2121—7.PMC 528928 .PMID 15489334.doi:10.1101/gr.2596504.
Kimura K; Wakamatsu A; Suzuki Y (2006).„Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.”.Genome Res.16 (1): 55—65.PMC 1356129 .PMID 16344560.doi:10.1101/gr.4039406.
Sirchia R, Luparello C (2007). „Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells.”.Biol. Chem.388 (5): 457—65.PMID 17516841.doi:10.1515/BC.2007.059.

Vidi još

[уреди |уреди извор]

Uvojiti receptori

Spoljašnje veze

[уреди |уреди извор]

„Frizzled Receptors: FZD₆”.IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано изоригинала 24. 01. 2016. г.

Transmembranski receptor:receptori spregnuti s G proteinom

Klasa A:Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A,B,D) • α2 (A,B,C) • β1 • β2 • β3
Purinski	Adenozinski (A1,A2A,A2B,A3) • P2Y (1,2,4,5,6,8,9,10,11,12,13,14)
Serotoninski	(svi osim 5-HT3)5-HT1 (A,B,D,E,F) • 5-HT2 (A,B,C) • 5-HT (4,5A,6,7)
Drugi	Acetilholin (M1,M2,M3,M4,M5) • Dopamin (D1,D2,D3,D4,D5) • Histamin (H1,H2,H3,H4) • Melatonin (1A,1B,1C) • TAAR (1,2,3,5,6,8,9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1,2) • LTB4 (1,2) • FPRL1 • OXE • Prostaglandin (DP (1,2),EP (1,2,3,4),FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1,CB2,GPR (18,55,119)) • EBI2 • Estrogen • Slobodna masna kiselina (1,2,3,4) • Laktat • Lizofosfatidna kiselina (1,2,3,4,5,6) • Lizofosfolipid (1,2,3,4,5,6,7,8) • Niacin (1,2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1,2,3,4,5) • Sukcinat

Peptid

Neuropeptidni

B/W (1,2) • FF (1,2) • S • Y (1,2,4,5) • Neuromedin (B,U (1,2)) • Neurotenzin (1,2)

Drugi

Anafilatoksin (C3a,C5a) • Angiotenzin (1,2) • Apelin • Bombezin (BRS3,GRPR,NMBR) • Bradikinin (B1,B2) • Hemokin • Holecistokinin (A,B) • Endotelin (A,B) • Formil peptid (1,2,3) • FSH • Galanin (1,2,3) • GHB receptor • Gonadotropin-oslobađajući hormon (1,2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1,1L,D,E,F,G,X1,X2,X3,X4) • Melanokortin (1,2,3,4,5) • MCHR (1,2) • Motilin • Opioidni (δ,κ,μ,Nociceptin &ζ, ali neσ) • Oreksin (1,2) • Oksitocin • Prokineticin (1,2) • Prolaktin-oslobađajući peptid • Relaksin (1,2,3,4) • Somatostatin (1,2,3,4,5) • Tahikinin (1,2,3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A,1B,2)

Razno

Orfan	GPR (1,3,4,6,12,15,17,18,19,20,21,22,23,25,26,27,31,32,33,34,35,37,39,42,44,45,50,52,55,61,62,63,65,68,75,77,78,81,82,83,84,85,87,88,92,101,103,109A,109B,119,120,132,135,137B,139,141,142,146,148,149,150,151,152,153,160,161,162,171,173,174,176,177,182,183)
Drugi	Adrenomedulin • Mirisni • Opsin (3,4,5,1LW,1MW,1SW,RGR,RRH) • Proteazom-aktivirani (1,2,3,4) • SREB (1,2,3)

Klasa B:Sekretinu slični

Orfan	GPR (56,64,97,98,110,111,112,113,114,115,116,123,124,125,126,128,133,143,144,155,157)
Drugi	Moždano specifični angiogenezni inhibitor (1,2,3) • Kadherin (1,2,3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1,2) • EMR (1,2,3) • Glukagon (GR,GIPR,GLP1R,GLP2R) • Hormon rasta • PACAPR1 • GPR • Latrofilin (1,2,3,ELTD1) • Metuzalemski protein • Paratiroidni hormon (1,2) • Sekretin • Vazoaktivni intestinalni peptid (1,2)

Klasa C:Metabotropni
glutamat /feromon

Ukus	TAS1R (1,2,3) • TAS2R (1,3,4,5,8,9,10,12,13,14,16,19,20,30,31,38,39,40,41,42,43,45,46,50)
Drugi	Kalcijum-detektujući receptor • GABA B (1,2) • Glutamatni receptor (Metabotropni glutamat (1,2,3,4,5,6,7,8)) • GPRC6A • GPR (156,158,179) • RAIG (1,2,3,4) • VNR (1,2,3,5)

Klasa F:
Frizzled /Zaglađeni

Uvojiti	Frizzled (1,2,3,4,5,6,7,8,9,10)
Zaglađeni	Zaglađeni

Преузето из „https://sr.wikipedia.org/w/index.php?title=FZD6&oldid=27559173”

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