CGP-7930 je jedinjenje koje se koristi u naučnim istraživanjima kaopozitivni alosterni modulatorGABABreceptor.[1][2][3][4] On imaanksiolitičko dejstvo u životinjskim studijama,[5][6] kao i sinergističke efekte sa GABAB agonistima, poputbaklofena iGHB.[7][8] On umanjuje samo-administracijuetanola ikokaina.[9][10]
- ^Urwyler, S.; Mosbacher, J.; Lingenhoehl, K.; Heid, J.; Hofstetter, K.; Froestl, W.; Bettler, B.; Kaupmann, K. (2001). „Positive allosteric modulation of native and recombinant gamma-aminobutyric acid(B) receptors by 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501”.Molecular Pharmacology.60 (5): 963—971.PMID 11641424.doi:10.1124/mol.60.5.963.
- ^Binet, V.; Brajon, C.; Le Corre, L.; Acher, F.; Pin, J. P.; Prézeau, L. (2004).„The heptahelical domain of GABA(B2) is activated directly by CGP7930, a positive allosteric modulator of the GABA(B) receptor”.The Journal of Biological Chemistry.279 (28): 29085—29091.PMC 2557059
.PMID 15126507.doi:10.1074/jbc.M400930200 . - ^Chen, Y.; Menendez-Roche, N.; Sher, E. (2006). „Differential modulation by the GABAB receptor allosteric potentiator 2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)-phenol (CGP7930) of synaptic transmission in the rat hippocampal CA1 area”.The Journal of Pharmacology and Experimental Therapeutics.317 (3): 1170—1177.PMID 16507713.S2CID 17821271.doi:10.1124/jpet.105.099176.
- ^Adams, C. L.; Lawrence, A. J. (2007).„CGP7930: A Positive Allosteric Modulator of the GABABReceptor”.CNS Drug Reviews.13 (3): 308—316.PMC 6494120 .PMID 17894647.doi:10.1111/j.1527-3458.2007.00021.x.
- ^Frankowska, M.; Filip, M.; Przegaliński, E. (2007). „Effects of GABAB receptor ligands in animal tests of depression and anxiety”.Pharmacological Reports : Pr.59 (6): 645—655.PMID 18195453.
- ^Jacobson, L. H.; Cryan, J. F. (2008). „Evaluation of the anxiolytic-like profile of the GABAB receptor positive modulator CGP7930 in rodents”.Neuropharmacology.54 (5): 854—862.PMID 18328507.S2CID 45852297.doi:10.1016/j.neuropharm.2008.01.004.
- ^Carai, M. A.; Colombo, G.; Froestl, W.; Gessa, G. L. (2004). „In vivo effectiveness of CGP7930, a positive allosteric modulator of the GABAB receptor”.European Journal of Pharmacology.504 (3): 213—216.PMID 15541424.doi:10.1016/j.ejphar.2004.10.008.
- ^Parker, D. A.; Marino, V.; Ong, J.; Puspawati, N. M.; Prager, R. H. (2008). „The CGP7930 analogue 2,6-di-tert-butyl-4-(3-hydroxy-2-spiropentylpropyl)-phenol (BSPP) potentiates baclofen action at GABA(B) autoreceptors”.Clinical and Experimental Pharmacology & Physiology.35 (9): 1113—1115.PMID 18430050.S2CID 25608408.doi:10.1111/j.1440-1681.2008.04948.x.
- ^Liang, J. H.; Chen, F.; Krstew, E.; Cowen, M. S.; Carroll, F. Y.; Crawford, D.; Beart, P. M.; Lawrence, A. J. (2006). „The GABA(B) receptor allosteric modulator CGP7930, like baclofen, reduces operant self-administration of ethanol in alcohol-preferring rats”.Neuropharmacology.50 (5): 632—639.PMID 16406445.S2CID 54264313.doi:10.1016/j.neuropharm.2005.11.011.
- ^Filip, M.; Frankowska, M.; Przegaliński, E. (2007). „Effects of GABA(B) receptor antagonist, agonists and allosteric positive modulator on the cocaine-induced self-administration and drug discrimination”.European Journal of Pharmacology.574 (2–3): 148—157.PMID 17698060.doi:10.1016/j.ejphar.2007.07.048.
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