Butirilholinesteraza (HGNC symbolBCHE), takođe poznata kaoBChE,BuChE,pseudoholinesteraza, ili(holin)esteraza plazme,[1] je nespecifičniholinesterazni enzim koji hidrolizuje mnoge različiteestre bazirane naholinu. Kod ljudi, ona se izražava u jetri, prisutna je uglavnom ukrvotoku, a kodirana jeBCHEgenom.[2]
Ovaj enzim je veoma sličan sa neuronskomacetilholinesterazom, koja je isto tako poznata kao RBC ili eritrocitna holinesteraza.[1] Termim "serumska holinesteraza" se generalno koristi u kontekstu kliničkog testa koji odražava nivoe ova dva enzima u krvi.[1] Test aktivnosti butirilholinesteraze u plazmi se može koristiti kaotest funkcije jetre pošto hiperholinesterasemija i hipoholinesterasemija indiciraju patoliške procese.
Butirilholin je sintetičko jedinjenje koje se prirodno ne javlja u telju. On se koristi za pravljenje razlike između acetilholinesteraze i butirilholinesteraze.
Butirilholinesteraza jeprofilaktički protivotrov protivorganofosfatnenervne agense. Ona vezuje nervne agense u krvotoku pre nego što oni deluju na nervni sistem. Pošto je ona biološko sredstvo za uklanjanje (i univerzalna meta), ona je trenutno jedini terapeutski agens koji efektivno pruža pruža kompletnustehiometrijsku zaštitu od celokupnog spektraa organofosfatnih nervnih agenasa.[3]
^абвJasmin L (28. 05. 2013).„Cholinesterase - blood”. University of Maryland Medical Center. Архивирано изоригинала 30. 10. 2012. г. Приступљено28. 10. 2016.
^Allderdice PW, Gardner HA, Galutira D, Lockridge O, LaDu BN, McAlpine PJ (1991). „The cloned butyrylcholinesterase (BCHE) gene maps to a single chromosome site, 3q26”.Genomics.11 (2): 452—4.PMID1769657.doi:10.1016/0888-7543(91)90154-7.
^Chen VP, Gao Y, Geng L, Parks RJ, Pang YP, Brimijoin S (2015). „Plasma butyrylcholinesterase regulates ghrelin to control aggression”.Proceedings of the National Academy of Sciences of the United States of America.112 (7): 2251—6.PMID25646463.doi:10.1073/pnas.1421536112.
^Brus B, Košak U, Turk S, Pišlar A, Coquelle N, Kos J, Stojan J, Colletier JP, Gobec S (2014). „Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor”.Journal of Medicinal Chemistry.57 (19): 8167—79.PMID25226236.doi:10.1021/jm501195e.
Bodur E, Cokugras AN (2005). „The effects of indole-3-acetic acid on human and horse serum butyrylcholinesterase”.Chemico-Biological Interactions. 157-158 (16): 375—378.PMID16429500.doi:10.1016/j.cbi.2005.10.061.
Allderdice PW, Gardner HA, Galutira D, Lockridge O, LaDu BN, McAlpine PJ (1991). „The cloned butyrylcholinesterase (BCHE) gene maps to a single chromosome site, 3q26”.Genomics.11 (2): 452—4.PMID1769657.doi:10.1016/0888-7543(91)90154-7.
Gaughan G, Park H, Priddle J, Craig I, Craig S (1991). „Refinement of the localization of human butyrylcholinesterase to chromosome 3q26.1-q26.2 using a PCR-derived probe”.Genomics.11 (2): 455—8.PMID1769658.doi:10.1016/0888-7543(91)90155-8.
Arpagaus M, Kott M, Vatsis KP, Bartels CF, La Du BN, Lockridge O (1990). „Structure of the gene for human butyrylcholinesterase. Evidence for a single copy”.Biochemistry.29 (1): 124—31.PMID2322535.doi:10.1021/bi00453a015.
Mattes C, Bradley R, Slaughter E, Browne S (1996). „Cocaine and butyrylcholinesterase (BChE): determination of enzymatic parameters”.Life Sciences.58 (13): PL257—61.PMID8622553.doi:10.1016/0024-3205(96)00065-3.
Iida S, Kinoshita M, Fujii H, Moriyama Y, Nakamura Y, Yura N, Moriwaki K (1996). „Mutations of human butyrylcholinesterase gene in a family with hypocholinesterasemia”.Human Mutation.6 (4): 349—51.PMID8680411.doi:10.1002/humu.1380060411.
Kamendulis LM, Brzezinski MR, Pindel EV, Bosron WF, Dean RA (1996). „Metabolism of cocaine and heroin is catalyzed by the same human liver carboxylesterases”.The Journal of Pharmacology and Experimental Therapeutics.279 (2): 713—7.PMID8930175.
Hidaka K, Iuchi I, Tomita M, Watanabe Y, Minatogawa Y, Iwasaki K, Gotoh K, Shimizu C (1997). „Genetic analysis of a Japanese patient with butyrylcholinesterase deficiency”.Annals of Human Genetics.61 (Pt 6): 491—6.PMID9543549.doi:10.1046/j.1469-1809.1997.6160491.x.
Altamirano CV, Lockridge O (1999). „Conserved aromatic residues of the C-terminus of human butyrylcholinesterase mediate the association of tetramers”.Biochemistry.38 (40): 13414—22.PMID10529218.doi:10.1021/bi991475.
Darvesh S, Kumar R, Roberts S, Walsh R, Martin E (2001). „Butyrylcholinesterase-Mediated enhancement of the enzymatic activity of trypsin”.Cellular and Molecular Neurobiology.21 (3): 285—96.PMID11569538.doi:10.1023/A:1010947205224.
Barta C, Sasvari-Szekely M, Devai A, Kovacs E, Staub M, Enyedi P (2001). „Analysis of mutations in the plasma cholinesterase gene of patients with a history of prolonged neuromuscular block during anesthesia”.Molecular Genetics and Metabolism.74 (4): 484—8.PMID11749053.doi:10.1006/mgme.2001.3251.
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