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Пређи на садржај
Википедија
Претрага

Apelinski receptor

С Википедије, слободне енциклопедије
Apelinski receptor
Identifikatori
SimboliAPLNR; FLJ90771; MGC45246; AGTRL1; HG11; APJR; APJ; FLJ96609
Vanjski IDOMIM600052MGI1346086HomoloGene3784IUPHAR:APJGeneCards:APLNR Gene
Ontologija gena
Molekularna funkcijaaktivnost purinskog nukleotidnog receptora, G-protein spregnutog
aktivnost bradikininskog receptora
aktivnost angiotenzinskog tip II receptora
receptorska aktivnost
aktivnost C-C hemokinskog receptora
aktivnost receptora trombocit aktivirajućeg faktora
aktivnost N-formil peptidnog receptora
aktivnost G-protein spregnutog receptora
Celularna komponentaintegralno sa ćelijskom membranom
integralno sa membranom
ćelijska membrana
Biološki processignalni put G-protein spregnutog receptora
prenos signala
hemotaksa
Ortolozi
VrstaČovekMiš
Entrez18723796
EnsemblENSG00000134817ENSMUSG00000044338
UniProtP35414Q9WV08
RefSeq (mRNA)NM_005161NM_011784
RefSeq (protein)NP_005152NP_035914
Lokacija (UCSC)Chr 11:
56.76 - 56.76 Mb
Chr 2:
84.98 - 84.98 Mb
PubMed pretraga[1][2]

Apelinski receptor (takođe poznatAPJ receptor) jeG protein-spregnuti receptor[1] koji vezujeapelin.[2][3][4]

Literatura

[уреди |уреди извор]
  1. ^O'Dowd BF, Heiber M, Chan A, Heng HH, Tsui LC, Kennedy JL, Shi X, Petronis A, George SR, Nguyen T (1993).„A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11”.Gene.136 (1-2): 355—60.PMID 8294032.doi:10.1016/0378-1119(93)90495-O. 
  2. ^Tatemoto K, Hosoya M, Habata Y, Fujii R, Kakegawa T, Zou MX, Kawamata Y, Fukusumi S, Hinuma S, Kitada C, Kurokawa T, Onda H, Fujino M (1998). „Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor”.Biochem. Biophys. Res. Commun.251 (2): 471—6.PMID 9792798.doi:10.1006/bbrc.1998.9489. 
  3. ^Lee DK, Cheng R, Nguyen T, Fan T, Kariyawasam AP, Liu Y, Osmond DH, George SR, O'Dowd BF (2000). „Characterization of apelin, the ligand for the APJ receptor”.J. Neurochem.74 (1): 34—41.PMID 10617103.doi:10.1046/j.1471-4159.2000.0740034.x. 
  4. ^Szokodi I, Tavi P, Földes G, Voutilainen-Myllylä S, Ilves M, Tokola H, Pikkarainen S, Piuhola J, Rysä J, Tóth M, Ruskoaho H (2002). „Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility”.Circ. Res.91 (5): 434—40.PMID 12215493.doi:10.1161/01.RES.0000033522.37861.69. 

Dodatna literatura

[уреди |уреди извор]
  • Hinohara K; Nakajima T; Sasaoka T; et al. (2009). „Validation of the association between AGTRL1 polymorphism and coronary artery disease in the Japanese and Korean populations.”.J. Hum. Genet.54 (9): HASH(0x28fffa0).PMID 19680269.doi:10.1038/jhg.2009.78. 
  • Hata J; Matsuda K; Ninomiya T; et al. (2007). „Functional SNP in an Sp1-binding site of AGTRL1 gene is associated with susceptibility to brain infarction.”.Hum. Mol. Genet.16 (6): 630—9.PMID 17309882.doi:10.1093/hmg/ddm005. 
  • Kälin RE; Kretz MP; Meyer AM; et al. (2007). „Paracrine and autocrine mechanisms of apelin signaling govern embryonic and tumor angiogenesis.”.Dev. Biol.305 (2): 599—614.PMID 17412318.doi:10.1016/j.ydbio.2007.03.004. 
  • Zhou N; Zhang X; Fan X; et al. (2003). „The N-terminal domain of APJ, a CNS-based coreceptor for HIV-1, is essential for its receptor function and coreceptor activity.”.Virology.317 (1): 84—94.PMID 14675627.doi:10.1016/j.virol.2003.08.026. 
  • Otsuki T; Ota T; Nishikawa T; et al. (2005). „Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.”.DNA Res.12 (2): 117—26.PMID 16303743.doi:10.1093/dnares/12.2.117. 
  • O'Carroll AM, Don AL, Lolait SJ (2003). „APJ receptor mRNA expression in the rat hypothalamic paraventricular nucleus: regulation by stress and glucocorticoids.”.J. Neuroendocrinol.15 (11): 1095—101.PMID 14622440.doi:10.1046/j.1365-2826.2003.01102.x. 
  • Sarzani R; Forleo C; Pietrucci F; et al. (2007). „The 212A variant of the APJ receptor gene for the endogenous inotrope apelin is associated with slower heart failure progression in idiopathic dilated cardiomyopathy.”.J. Card. Fail.13 (7): 521—9.PMID 17826642.doi:10.1016/j.cardfail.2007.04.002. 
  • Langelaan DN, Bebbington EM, Reddy T, Rainey JK (2009). „Structural insight into G-protein coupled receptor binding by apelin.”.Biochemistry.48 (3): 537—48.PMID 19123778.doi:10.1021/bi801864b. 
  • Zhou N; Fan X; Mukhtar M; et al. (2003). „Cell-cell fusion and internalization of the CNS-based, HIV-1 co-receptor, APJ.”.Virology.307 (1): 22—36.PMID 12667811.doi:10.1016/S0042-6822(02)00021-1. 
  • Li WW; Niu WQ; Zhang Y; et al. (2009). „Family-based analysis of apelin and AGTRL1 gene polymorphisms with hypertension in Han Chinese.”.J. Hypertens.27 (6): 1194—201.PMID 19307984.doi:10.1097/HJH.0b013e32832a3eb1. 
  • Gerhard DS; Wagner L; Feingold EA; et al. (2004).„The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”.Genome Res.14 (10B): 2121—7.PMC 528928Слободан приступ.PMID 15489334.doi:10.1101/gr.2596504. 
  • Lee DK; Lança AJ; Cheng R; et al. (2004). „Agonist-independent nuclear localization of the Apelin, angiotensin AT1, and bradykinin B2 receptors.”.J. Biol. Chem.279 (9): 7901—8.PMID 14645236.doi:10.1074/jbc.M306377200. 
  • Choe H; Martin KA; Farzan M; et al. (1998). „Structural interactions between chemokine receptors, gp120 Env and CD4.”.Semin. Immunol.10 (3): 249—57.PMID 9653051.doi:10.1006/smim.1998.0127. 
  • Ota T; Suzuki Y; Nishikawa T; et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs.”.Nat. Genet.36 (1): 40—5.PMID 14702039.doi:10.1038/ng1285. 
  • Kleinz MJ, Skepper JN, Davenport AP (2005). „Immunocytochemical localisation of the apelin receptor, APJ, to human cardiomyocytes, vascular smooth muscle and endothelial cells.”.Regul. Pept.126 (3): 233—40.PMID 15664671.doi:10.1016/j.regpep.2004.10.019. 
  • Luttrell LM (2008). „Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.”.Mol. Biotechnol.39 (3): 239—64.PMID 18240029.doi:10.1007/s12033-008-9031-1. 
  • Cobellis L; De Falco M; Mastrogiacomo A; et al. (2007). „Modulation of apelin and APJ receptor in normal and preeclampsia-complicated placentas.”.Histol. Histopathol.22 (1): 1—8.PMID 17128405. 
  • Kubo M (2008). „[Genetic risk factors of ischemic stroke identified by a genome-wide association study]”.Brain and nerve = Shinkei kenkyÅ« no shinpo.60 (11): 1339—46.PMID 19069168. 
  • Bai B; Tang J; Liu H; et al. (2008). „Apelin-13 induces ERK1/2 but not p38 MAPK activation through coupling of the human apelin receptor to the Gi2 pathway.”.Acta Biochim. Biophys. Sin. (Shanghai).40 (4): 311—8.PMID 18401529.doi:10.1111/j.1745-7270.2008.00403.x. 
  • Ishida J; Hashimoto T; Hashimoto Y; et al. (2004). „Regulatory roles for APJ, a seven-transmembrane receptor related to angiotensin-type 1 receptor in blood pressure in vivo.”.J. Biol. Chem.279 (25): 26274—9.PMID 15087458.doi:10.1074/jbc.M404149200. 

Spoljašnje veze

[уреди |уреди извор]
Klasa A:Rodopsinu slični
Neurotransmiter
Adrenergički
α1 (A,B,D) • α2 (A,B,C) • β1 • β2 • β3
Purinski
Serotoninski
(svi osim 5-HT3)5-HT1 (A,B,D,E,F) • 5-HT2 (A,B,C) • 5-HT (4,5A,6,7)
Drugi
Acetilholin (M1,M2,M3,M4,M5) • Dopamin (D1,D2,D3,D4,D5) • Histamin (H1,H2,H3,H4) • Melatonin (1A,1B,1C) • TAAR (1,2,3,5,6,8,9)
Metaboliti i
signalni molekuli
Eikozanoidni
CysLT (1,2) • LTB4 (1,2) • FPRL1 • OXE • Prostaglandin (DP (1,2),EP (1,2,3,4),FP) • Prostaciklin • Tromboksan
Drugi
Peptid
Neuropeptidni
B/W (1,2) • FF (1,2) • S • Y (1,2,4,5) • Neuromedin (B,U (1,2)) • Neurotenzin (1,2)
Drugi
Razno
Orfan
Drugi
Klasa B:Sekretinu slični
Orfan
Drugi
Klasa C:Metabotropni
glutamat /feromon
Ukus
TAS1R (1,2,3) • TAS2R (1,3,4,5,8,9,10,12,13,14,16,19,20,30,31,38,39,40,41,42,43,45,46,50)
Drugi
Klasa F:
Frizzled /Zaglađeni
Uvojiti
Zaglađeni
Apelinski receptor nasrodnim projektima Vikipedije:
Podaci na Vikipodacima
Преузето из „https://sr.wikipedia.org/w/index.php?title=Apelinski_receptor&oldid=29179354
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