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ACTH receptor

Уреди везе

С Википедије, слободне енциклопедије

Melanokortin 2 receptor (adrenokortikotropski hormon)

Identifikatori

Simboli

MC2R; ACTHR; MGC125798

Vanjski ID

OMIM: 607397MGI: 96928HomoloGene: 444IUPHAR:MC₂GeneCards:MC2R Gene

Ontologija gena
Molekularna funkcija	•rodopsinu-slična receptorska aktivnost •receptorska aktivnost •adrenokortikotropska receptorska aktivnost
Celularna komponenta	•integralno sa membranom plazme •membrana
Biološki proces	•prenos signala •G-protein signalizacija, spregnuta sa cikličnim nukleotidnim drugim glasnikom

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

RefSeq (mRNA)

RefSeq (protein)

Lokacija (UCSC)

Chr 18:
13.87 - 13.91 Mb

Chr 18:
68.53 - 68.55 Mb

PubMed pretraga

[1]

[2]

ACTH receptor je tipmelanokortin receptora (tip 2), takođe poznat kaoMC₂, koji je specifičan zaACTH.^[1]

On je rasprostranjen uzona fasciculata ljudskogadrenalnog korteksa. ACTH vezivanje za receptor stimuliše produkcijukortizola. (U kontrastu s tim, produkcijaaldosterona izzona glomerulosa je stimulisana primarnoangiotenzinom II.)

ACTH receptor koristicAMP kao sekundarni glasnik.^[2]

Mutacije ovog receptora uzrokujuglukokortikoidnu deficijenciju tipa 1, u kojoj pacijenti imaju visoke ACTH nivoe u serumu, i niske nivoekortizola.^[3]^[4]

Vidi još

[уреди |уреди извор]

Melanokortin receptor

Literatura

[уреди |уреди извор]

^Beuschlein F, Fassnacht M, Klink A, Allolio B, Reincke M (2001). „ACTH-receptor expression, regulation and role in adrenocortial tumor formation”.Eur. J. Endocrinol.144 (3): 199—206.PMID 11248736.doi:10.1530/eje.0.1440199.
^Elias LL, Clark AJ (2000). „The expression of the ACTH receptor”.Brazilian Journal of Medical and Biological Research.33 (10): 1245—1248.PMID 11004726.doi:10.1590/S0100-879X2000001000015.
^Clark AJ, McLoughlin L, Grossman A (1993).„Familial glucocorticoid deficiency associated with point mutation in the adrenocorticotropin receptor”.Lancet.341 (8843): 461—462.PMID 8094489.doi:10.1016/0140-6736(93)90208-X.
^Tsigos C, Arai K, Hung W, Chrousos GP (1993).„Hereditary isolated glucocorticoid deficiency is associated with abnormalities of the adrenocorticotropin receptor gene”.J. Clin. Invest.92 (5): 2458—2461.PMC 288430 .PMID 8227361.doi:10.1172/JCI116853.

Dodatna literatura

[уреди |уреди извор]

Cone RD; Mountjoy KG; Robbins LS; et al. (1993).„Cloning and functional characterization of a family of receptors for the melanotropic peptides.”.Ann. N. Y. Acad. Sci.680: 342—63.PMID 8390157.doi:10.1111/j.1749-6632.1993.tb19694.x.
Allolio B, Reincke M (1997). „Adrenocorticotropin receptor and adrenal disorders.”.Horm. Res.47 (4-6): 273—8.PMID 9167964.doi:10.1159/000185476.
Tatro JB (1997). „Receptor biology of the melanocortins, a family of neuroimmunomodulatory peptides.”.Neuroimmunomodulation.3 (5): 259—84.PMID 9218248.doi:10.1159/000097281.
Mountjoy KG, Robbins LS, Mortrud MT, Cone RD (1992).„The cloning of a family of genes that encode the melanocortin receptors.”.Science.257 (5074): 1248—51.PMID 1325670.doi:10.1126/science.1325670.
Clark AJ, McLoughlin L, Grossman A (1993).„Familial glucocorticoid deficiency associated with point mutation in the adrenocorticotropin receptor.”.Lancet.341 (8843): 461—2.PMID 8094489.doi:10.1016/0140-6736(93)90208-X.
Tsigos C, Arai K, Hung W, Chrousos GP (1993).„Hereditary isolated glucocorticoid deficiency is associated with abnormalities of the adrenocorticotropin receptor gene.”.J. Clin. Invest.92 (5): 2458—61.PMC 288430 .PMID 8227361.doi:10.1172/JCI116853.
Gantz I; Tashiro T; Barcroft C; et al. (1994). „Localization of the genes encoding the melanocortin-2 (adrenocorticotropic hormone) and melanocortin-3 receptors to chromosomes 18p11.2 and 20q13.2-q13.3 by fluorescence in situ hybridization.”.Genomics.18 (1): 166—7.PMID 8276410.doi:10.1006/geno.1993.1448.
Gantz I; Konda Y; Tashiro T; et al. (1993).„Molecular cloning of a novel melanocortin receptor.”.J. Biol. Chem.268 (11): 8246—50.PMID 8463333.
Naville D; Barjhoux L; Jaillard C; et al. (1996). „Demonstration by transfection studies that mutations in the adrenocorticotropin receptor gene are one cause of the hereditary syndrome of glucocorticoid deficiency.”.J. Clin. Endocrinol. Metab.81 (4): 1442—8.PMID 8636348.doi:10.1210/jc.81.4.1442.
Naville D; Jaillard C; Barjhoux L; et al. (1997). „Genomic structure and promoter characterization of the human ACTH receptor gene.”.Biochem. Biophys. Res. Commun.230 (1): 7—12.PMID 9020063.doi:10.1006/bbrc.1996.5911.
Yang YK; Ollmann MM; Wilson BD; et al. (1997). „Effects of recombinant agouti-signaling protein on melanocortin action.”.Mol. Endocrinol.11 (3): 274—80.PMID 9058374.doi:10.1210/me.11.3.274.
Naville D; Barjhoux L; Jaillard C; et al. (1997).„Stable expression of normal and mutant human ACTH receptor: study of ACTH binding and coupling to adenylate cyclase.”.Mol. Cell. Endocrinol.129 (1): 83—90.PMID 9175632.doi:10.1016/S0303-7207(97)04043-4.
Penhoat A; Naville D; Jaillard C; et al. (1997). „Presence of multiple functional polyadenylation signals in the 3'-untranslated region of human corticotropin receptor cDNA.”.Biochim. Biophys. Acta.1356 (3): 249—52.PMID 9194567.doi:10.1016/S0167-4889(97)00031-1.
Ishii T; Ogata T; Sasaki G; et al. (2000).„Novel mutations of the ACTH receptor gene in a female adult patient with adrenal unresponsiveness to ACTH.”.Clin. Endocrinol. (Oxf).53 (3): 389—92.PMID 10971458.doi:10.1046/j.1365-2265.2000.01040.x.
Flück CE, Martens JW, Conte FA, Miller WL (2002). „Clinical, genetic, and functional characterization of adrenocorticotropin receptor mutations using a novel receptor assay.”.J. Clin. Endocrinol. Metab.87 (9): 4318—23.PMID 12213892.doi:10.1210/jc.2002-020501.
Swords FM; Baig A; Malchoff DM; et al. (2003). „Impaired desensitization of a mutant adrenocorticotropin receptor associated with apparent constitutive activity.”.Mol. Endocrinol.16 (12): 2746—53.PMID 12456795.doi:10.1210/me.2002-0099.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003).„Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”.Proc. Natl. Acad. Sci. U.S.A.99 (26): 16899—903.PMC 139241 .PMID 12477932.doi:10.1073/pnas.242603899.
„Melanocortin Receptors: MC₂”.IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано изоригинала 03. 03. 2016. г.

Spoljašnje veze

[уреди |уреди извор]

MC2+Receptor наUS National Library of Medicine Medical Subject Headings (MeSH)

Transmembranski receptor:receptori spregnuti s G proteinom

Klasa A:Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A,B,D) • α2 (A,B,C) • β1 • β2 • β3
Purinski	Adenozinski (A1,A2A,A2B,A3) • P2Y (1,2,4,5,6,8,9,10,11,12,13,14)
Serotoninski	(svi osim 5-HT3)5-HT1 (A,B,D,E,F) • 5-HT2 (A,B,C) • 5-HT (4,5A,6,7)
Drugi	Acetilholin (M1,M2,M3,M4,M5) • Dopamin (D1,D2,D3,D4,D5) • Histamin (H1,H2,H3,H4) • Melatonin (1A,1B,1C) • TAAR (1,2,3,5,6,8,9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1,2) • LTB4 (1,2) • FPRL1 • OXE • Prostaglandin (DP (1,2),EP (1,2,3,4),FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1,CB2,GPR (18,55,119)) • EBI2 • Estrogen • Slobodna masna kiselina (1,2,3,4) • Laktat • Lizofosfatidna kiselina (1,2,3,4,5,6) • Lizofosfolipid (1,2,3,4,5,6,7,8) • Niacin (1,2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1,2,3,4,5) • Sukcinat

Peptid

Neuropeptidni

B/W (1,2) • FF (1,2) • S • Y (1,2,4,5) • Neuromedin (B,U (1,2)) • Neurotenzin (1,2)

Drugi

Anafilatoksin (C3a,C5a) • Angiotenzin (1,2) • Apelin • Bombezin (BRS3,GRPR,NMBR) • Bradikinin (B1,B2) • Hemokin • Holecistokinin (A,B) • Endotelin (A,B) • Formil peptid (1,2,3) • FSH • Galanin (1,2,3) • GHB receptor • Gonadotropin-oslobađajući hormon (1,2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1,1L,D,E,F,G,X1,X2,X3,X4) • Melanokortin (1,2,3,4,5) • MCHR (1,2) • Motilin • Opioidni (δ,κ,μ,Nociceptin &ζ, ali neσ) • Oreksin (1,2) • Oksitocin • Prokineticin (1,2) • Prolaktin-oslobađajući peptid • Relaksin (1,2,3,4) • Somatostatin (1,2,3,4,5) • Tahikinin (1,2,3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A,1B,2)

Razno

Orfan	GPR (1,3,4,6,12,15,17,18,19,20,21,22,23,25,26,27,31,32,33,34,35,37,39,42,44,45,50,52,55,61,62,63,65,68,75,77,78,81,82,83,84,85,87,88,92,101,103,109A,109B,119,120,132,135,137B,139,141,142,146,148,149,150,151,152,153,160,161,162,171,173,174,176,177,182,183)
Drugi	Adrenomedulin • Mirisni • Opsin (3,4,5,1LW,1MW,1SW,RGR,RRH) • Proteazom-aktivirani (1,2,3,4) • SREB (1,2,3)

Klasa B:Sekretinu slični

Orfan	GPR (56,64,97,98,110,111,112,113,114,115,116,123,124,125,126,128,133,143,144,155,157)
Drugi	Moždano specifični angiogenezni inhibitor (1,2,3) • Kadherin (1,2,3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1,2) • EMR (1,2,3) • Glukagon (GR,GIPR,GLP1R,GLP2R) • Hormon rasta • PACAPR1 • GPR • Latrofilin (1,2,3,ELTD1) • Metuzalemski protein • Paratiroidni hormon (1,2) • Sekretin • Vazoaktivni intestinalni peptid (1,2)

Klasa C:Metabotropni
glutamat /feromon

Ukus	TAS1R (1,2,3) • TAS2R (1,3,4,5,8,9,10,12,13,14,16,19,20,30,31,38,39,40,41,42,43,45,46,50)
Drugi	Kalcijum-detektujući receptor • GABA B (1,2) • Glutamatni receptor (Metabotropni glutamat (1,2,3,4,5,6,7,8)) • GPRC6A • GPR (156,158,179) • RAIG (1,2,3,4) • VNR (1,2,3,5)

Klasa F:
Frizzled /Zaglađeni

Uvojiti	Frizzled (1,2,3,4,5,6,7,8,9,10)
Zaglađeni	Zaglađeni

Neuropeptidni ligandi

Holecistokinin

CCK_A	Agonisti:Holecistokinin •CCK-4 Antagonisti:Asperlicin •Proglumid •Lorglumid •Devazepid •Deksloksiglumid
CCK_B	Agonisti:Holecistokinin •CCK-4 •Gastrin Antagonisti:Proglumid •CI-988

CRH

CRF₁	Agonisti:Kortikotropin-oslobađajuči hormon Antagonisti:Antalarmin •CP-154,526 •Peksacerfont
CRF₂	Agonisti:Kortikotropin-oslobađajuči hormon

Galanin

GAL₁	Agonisti:Galanin •Galaninu-sličan peptid •Galmic •Galnon
GAL₂	Agonisti:Galanin •Galaninu-sličan peptid •Galmic •Galnon
GAL₃	Agonisti:Galanin •Galmic •Galnon

Grelin

Agonisti:Grelin •Kapromorelin •MK-677 •Sermorelin •SM-130,686 •Tabimorelin

MCH

MCH₁	Agonisti:Melanin-koncentrirajući hormon Antagonisti:ATC-0175 •GW-803,430 •NGD-4715 •SNAP-7941 •SNAP-94847
MCH₂	Agonisti:Melanin-koncentrirajući hormon

Melanokortin

MC₁	Agonisti:alfa-MSH •Afamelanotid •Bremelanotid •Melanotan II Antagonisti:Agouti signalni peptid
MC₂	Agonisti:ACTH •Kosintropin •Tetrakosaktid
MC₃	Agonisti:alfa-MSH •Bremelanotid •Melanotan II
MC₄	Agonisti:alfa-MSH •Bremelanotid •Melanotan II •THIQ Antagonisti:Agutiju srodni peptid
MC₅	Agonisti:alfa-MSH •Melanotan II

Neuropeptid S

Agonisti:Neuropeptid S
Antagonisti:SHA-68

Neuropeptid Y

Y₁	Agonisti:Neuropeptid Y •Peptid YY Antagonisti:BIBP-3226
Y₂	Agonisti:Neuropeptid Y •Peptid YY Antagonisti:BIIE-0246
Y₄	Agonisti:Neuropeptid Y •Pankreasni polipeptid •Peptid YY Antagonisti:UR-AK49
Y₅	Agonisti:Neuropeptid Y •Peptid YY Antagonisti:Lu AA-33810

Neurotenzin

NTS₁	Agonisti:Neurotenzin •Neuromedin N Antagonisti:SR-48692 •SR-142,948
NTS₂	Agonisti:Neurotenzin Antagonisti:Levokabastin •SR-142,948

Opioid

vidiOpioidi

Oreksin

OX₁	Agonisti:Oreksin-A Antagonisti:Almoreksant •SB-334,867 •SB-408,124 •SB-649,868
OX₂	Agonisti:Oreksin-A Antagonisti:Almoreksant •SB-649,868 •TCS-OX2-29

Oksitocin

Agonisti:Karbetocin •Demoksitocin •Oksitocin •WAY-267,464
Antagonisti:Atosiban •L-371,257 •L-368,899

Tahikinin

NK₁	Agonisti:Supstanca P Antagonisti:Aprepitant •Befetupitant •Kasopitant •CI-1021 •CP-96,345 •CP-99,994 •CP-122,721 •Dapitant •Ezlopitant •FK-888 •Fosaprepitant •GR-203,040 •GW-597,599 •HSP-117 •L-733,060 •L-741,671 •L-743,310 •L-758,298 •Lanepitant •LY-306,740 •Maropitant •Netupitant •NKP-608 •Nolpitantium •Orvepitant •RP-67,580 •SDZ NKT 343 •Vestipitant •Vofopitant
NK₂	Agonisti:Neurokinin A Antagonisti:GR-159897 •Ibodutant •Saredutant
NK₃	Agonisti:Neurokinin B Antagonisti:Osanetant •Talnetant

Vazopresin

V_1A	Agonisti:Dezmopresin •Felipresin •Ornipresin •Terlipresin •Vazopresin Antagonisti:Konivaptan •Demeklociklin •Relkovaptan
V_1B	Agonisti:Felipresin •Ornipresin •Terlipresin •Vazopresin Antagonisti:Demeklociklin •Nelivaptan
V₂	Agonisti:Dezmopresin •Ornipresin •Vazopresin Antagonisti:Konivaptan •Demeklociklin •Liksivaptan •Mozavaptan •Satavaptan •Tolvaptan

Преузето из „https://sr.wikipedia.org/w/index.php?title=ACTH_receptor&oldid=30638309”

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