- Neil Armstrong (1960s and 1970, graduate studies) (M.S. Aerospace Engineering) – astronaut and the first person to walk on the Moon, NASAX-15 pilot[6][7]
- Charles A. Bassett, II (1960s, graduate studies) – Air Force test pilot, was selected as a NASA astronaut in 1963 but died in an airplane crash during training for his first spaceflight[8]
- Karol J. Bobko (1970, M.S. Aerospace Engineering) – engineer, Air Force officer and USAF and NASA astronaut[9]
- Charles F. Bolden, Jr. (1977, M.S. Systems Management) –Space Shuttle commander;Administrator of NASA[10]
- Gerald P. Carr (1954, B.S. Mechanical Engineering) – colonel in the Marine Corps and NASA astronaut[11]
- Nancy J. Currie (1985, M.S. Systems Management) – engineer, Army officer and NASA astronaut[12]
- William H. Dana (1958, M.S. Aerospace Engineering) – NASA test pilot and astronaut[13]
- Brian Duffy (1981, M.S. Systems Management) – U.S. Air Force colonel and NASA astronaut[14]
- Henry C. Gordon (1966, M.B.A.) – X-20 Dyna-Soar astronaut and a colonel in the Air Force[15]
- Nathan J. Lindsay (1976, M.S. Systems Management) – major general in the Air Force[16]
- Jerry M. Linenger (1988, M.S. Systems Management) – captain in the Navy Medical Corps, and NASA astronaut[17]
- James A. Lovell (1961, Aviation Safety School) – NASA astronaut and captain in the Navy, most famous as commander of Apollo 13 mission[18]
- Carlos I. Noriega (1981, B.S. Computer Science) – NASA astronaut and Marine Corps lieutenant colonel[19]
- Kenneth S. Reightler, Jr. (1984, M.S. Systems Management) – NASA astronaut[20]
- Walter M. Schirra (1969, Honorary Doctorate in Science) – test pilot, Navy officer, and one of the original Mercury Seven astronauts chosen for Project Mercury[21]
- Pierre J. Thuot (1985, M.S. Systems Management) – Navy captain and NASA astronaut[22]
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