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Theodor Boveri

From Simple English Wikipedia, the free encyclopedia
Theodor Boveri
Born12 October 1862
Died15 October 1915
NationalityGerman
Known forEmbryonic development
Boveri-Sutton chromosome theory
Centrosome
Scientific career
FieldsGenetics,Cell biology

Theodor Heinrich Boveri (12 October 1862 – 15 October 1915) was aGermanbiologist who made discoveries incytology,embryology andgenetics. His career was devoted to the processes whereby a new individual arises from parental reproductive materials.[1]

His work withsea urchins showed that it was necessary to have allchromosomes present in order for proper development of theembryo to take place.[2] This discovery was an important part of the Boveri-Sutton chromosome theory. His other significant discovery was thecentrosome (1888), which he described as theespecial organ of cell division. Boveri also discovered the phenomenon ofchromatin diminution during embryonic development of the nematodeParascaris.[3][4]

Boveri–Sutton hypothesis

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1902–1904: Boveri, in a series of papers, drew attention to the correspondence between the behaviour of chromosomes and the results obtained by Mendel.[5] He said that chromosomes were "independent entities which retain their independence even in the resting nucleus... What comes out of the nucleus is what goes into it".

In 1903Walter Sutton suggested that chromosomes, which segregate in a Mendelian fashion, are hereditary units.[6]E.B. Wilson, who was Sutton's teacher, called this theSutton–Boveri hypothesis.

Cancer

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Boveri reasoned that acancerous tumor begins with a singlecell in which the make up of its chromosomes becomes scrambled, causing the cells to divide uncontrollably.[7]

It was only later that researchers such asThomas Hunt Morgan showed that Boveri was correct.[8]

Other websites

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References

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  1. Baltzer, Fritz 1967.Theodor Boveri: The life of a great biologist 1862–1915. University of California Press, Berkeley.http://www.devbio.com/article.php?ch=7&id=75Archived 2005-02-28 at theWayback Machine
  2. Laubichler, Manfred D.; Davidson, Eric H. (2008)."Boveri's long experiment: sea urchin merogones and the establishment of the role of nuclear chromosomes in development".Developmental Biology.314 (1):1–11.doi:10.1016/j.ydbio.2007.11.024.PMC 2247478.PMID 18163986.
  3. Moritz, K. B.; Sauer, H. W. (1996). "Boveri's contributions to developmental biology--a challenge for today".Int. J. Dev. Biol.40 (1):27–47.PMID 8735909.
  4. Baltzer F. (1964)."Theodor Boveri".Science.144 (3620):809–15.Bibcode:1964Sci...144..809B.doi:10.1126/science.144.3620.809.PMID 14149391.
  5. Boveri T. 1904.Ergebnisse uber die Konstitution der chromatischen Substanz des Zellkerns. Fischer, Jena.
  6. Ernest W. Crow and James F. Crow (2002)."100 Years Ago: Walter Sutton and the chromosome theory of heredity".Genetics.160 (1):1–4.doi:10.1093/genetics/160.1.1.PMC 1461948.PMID 11805039.{{cite journal}}: CS1 maint: date and year (link)
  7. Boveri, Theodor (2008),"Concerning the origin of malignant tumours",Journal of Cell Science,121 (Supplement 1):1–84,doi:10.1242/jcs.025742,PMID 18089652,S2CID 9033401, archived fromthe original on 2010-02-17, retrieved2009-11-18
  8. STERN, C (1950)."Boveri and the early days of genetics".Nature.166 (4219): 446.Bibcode:1950Natur.166..446S.doi:10.1038/166446a0.PMID 14775717.S2CID 4189392.
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