At eight years old, Michele went with a friend to an opencasting call for amusical. She decided on a whim she wanted to try out. She was offered the part and made her debut on Broadway in 1995 as a replacement in the role of Young Cosette in the New York City showing ofLes Misérables. Then, in 1998, she played Tateh's daughter, the Little Girl, in the originalBroadway cast ofRagtime. In 2004, Michele played Shprintze and Chava in the Broadway revival of the musicalFiddler on the Roof. She also sang on the 2003 Broadway revival cast recording ofFiddler on the Roof.
She played the role of Wendla inSteven Sater andDuncan Sheik's musical version ofSpring Awakening, starring in early workshops toOff-Broadway and finally playing the role in the Broadway production at the age of 20.[9] Around the same time that the show was set to go to Broadway, she was offered the role of Eponine in the Broadway revival ofLes Misérables.[10] She decided to remain withSpring Awakening, which debuted on Broadway in December 2006. She was nominated for aDrama Desk Award for her acting inSpring Awakening in the category of Outstanding Actress in a Musical.[11]
On May 18, 2008, Michele leftSpring Awakening with co-starJonathan Groff. She acted in a reading of Sheik and Sater's new musical,Nero, in July 2008 atVassar College.[12] From August 8–August 10, 2008, she played Eponine in theHollywood Bowl'sLes Misérables concert. She sings on the original Broadway cast recordings ofRagtime andSpring Awakening.
Michele was included inTime magazine's 2010 list of the100 Most Influential People In the World.[15]FHM named her #7 on 2010 Sexiest Women List, which was the highest ranking for a new entry on the list that year.[16] Michele was named toPeople Magazine's Best Dressed List of 2010 as "The Newbie"[17] and she was voted "2010 Most Stylish Star" by E! Online.[18]
Michele is active incharities forgay rights andanimal rights, as well as in numerous other charities. In 2008, Michele was a part of thePETA ad campaign "Buck Cruelty! Say No to Horse-Drawn Carriage Rides".[23] In April 2010, Michele appeared in aPSA for PETA speaking out againstfur clothing.[24] In September 2010, Michele was honored by PETA for her work for animals.[25] In addition to working with PETA, Michele is also avegan.[26]
In 2008, Michele performed at a benefit concert, "Alive in the World",[30] to aid theTwin Tower Orphan Fund. Michele has also been active withBroadway Cares/Equity Fights AIDS. For Broadway Cares, Michele has participated in Broadway Barks, Broadway Bares,Easter Bonnet Competition and TheFlea Market and GrandAuction. In October 2010, Michele performed at a benefit concert for the Painted Turtle, a camp for children with illnesses. The concert celebrated the 35th anniversary ofThe Rocky Horror Picture Show, with Michele playing the lead role of Janet Weiss for the benefit.[31] In February 2011 she performed forThe Grammy's MusiCares Benefit inLos Angeles,California. Money earned by the event go to helpmusicians in need.[32]