SimNPH

Usage

remotes::install_git("https://github.com/SimNPH/SimNPH.git")

Results of the Simulation Study

The results of the simulation study done by the CONFIRMS consortium in the course of the EMA tender are published in the paperA Comparison of Statistical Methods for Time-To-Event Analyses in Randomized Controlled Trials Under Non-Proportional Hazards, Klinglmüller et al. (2025) and are presented in ashinylive App.

Reproducing the Results of the Simulation study

The parameters for the simulations were set using the following scripts:

• scripts/set_parameters_delayed_effect.R
• scripts/set_parameters_crossing_hazards.R
• scripts/set_parameters_subgroup.R
• scripts/set_parameters_progression.R

The simulations were then run using the following scripts:

• scripts/run_simulations_delayed_effect.R
• scripts/run_simulations_crossing_hazards.R
• scripts/run_simulations_subgroup.R
• scripts/run_simulations_progression.R

Which in turn usescripts/run_simulations_common.R.

All scripts are executed with the base directory of this repository as working directory.

Changes since the conduct of the simulation study:

• The version number of SimNPH was increased, to reproduce the simulation study, remove the check fromrun_simulations_...
• Simulation parameters and results were previously stored in the folderdata. This folder was renamed todata_sim_study becausedata is reserved for the use in R packages. Change the paths accordingly.
• Therun_simulations_... scripts use the parameters from a specified data. If you want to use parameter-values you generated yourself, update the path accordingly.

Re-Using the Scenarios

If you want to re-use the scenarios from the simulation study to investigate additional methods, use the scripts and documentation provided in theSimTemplate github repository. Also refer to the documentation oncontributing. If you do so please cite the simulation study, you can get a bibtex entry withcitation(package="SimNPH").