Triptofan 5-monooksigenaza (EC1.14.16.4,L-triptofanska hidroksilaza,indolsirćetna kiselina-5-hidroksilaza,triptofanska 5-hidroksilaza,triptofanska hidroksilaza) jeenzim sa sistematskim imenomL-triptofan,tetrahidrobiopterin:kiseonik oksidoreduktaza (5-hidroksilacija).[1][2][3][4][5] Ovaj enzimkatalizuje sledećuhemijsku reakciju
- L-triptofan +tetrahidrobiopterin + O2
5-hidroksi-L-triptofan + 4a-hidroksitetrahidrobiopterin
Aktivni centar sadrži mononuklearnogvožđe(II). Enzim se aktivira fosforilacijom, koju katalizuje Ca2+-aktiviranaproteinska kinaza.
- ↑Friedman, P.A., Kappelman, A.H. and Kaufman, S. (1972). „Partial purification and characterization of tryptophan hydroxylase from rabbit hindbrain”. J. Biol. Chem. 247: 4165-4173. PMID 4402511.
- ↑Hamon, M., Bourgoin, S., Artaud, F. and Glowinski, J. (1979). „The role of intraneuronal 5-HT and of tryptophan hydroxylase activation in the control of 5-HT synthesis in rat brain slices incubated in K+-enriched medium”. J. Neurochem. 33: 1031-1042. PMID 315449.
- ↑Ichiyama, A., Nakamura, S., Nishizuka, Y. and Hayaishi, O. (1970). „Enzymic studies on the biosynthesis of serotonin in mammalian brain”. J. Biol. Chem. 245: 1699-1709. PMID 5309585.
- ↑Jequier, E., Robinson, B.S., Lovenberg, W. and Sjoerdsma, A. (1969). „Further studies on tryptophan hydroxylase in rat brainstem and beef pineal”. Biochem. Pharmacol. 18: 1071-1081. PMID 5789774.
- ↑Wang, L., Erlandsen, H., Haavik, J., Knappskog, P.M. and Stevens, R.C. (2002). „Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin”. Biochemistry 41: 12569-12574. PMID 12379098.
