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Torasemid

Izvor: Wikipedija
Torasemid
(IUPAC) ime
1- {4-[(3-metilfenil)amino]piridin-3-sulfonil3-(propan-2-il)ureja
Klinički podaci
Robne markeDemadex, Luprac
AHFS/Drugs.comMonografija
Identifikatori
CAS broj56211-40-6
ATC kodC03CA01 ,C03CA04
PubChem[1][2]41781
DrugBankDB00214
ChemSpider[3]38123
Hemijski podaci
FormulaC16H20N4O3S 
Mol. masa348.42
SMILESeMolekuli &PubHem
InChI
InChI=1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21)
Key: NGBFQHCMQULJNZ-UHFFFAOYSA-N DaY
Fizički podaci
Tačka topljenja164-164 °C (-99 °F)
Farmakokinetički podaci
Poluvreme eliminacije3,5 sati
IzlučivanjeHepatički metabilizam 80%
Farmakoinformacioni podaci
Trudnoća?
Pravni status
Način primeneIntravenozno; Oralno

Torasemid (rINN) ilitorsemid (USAN) je piridin-sulfonilurejni tipdiuretika koji se uglavnom koristi za kontrolisanjeotoka uzrokovanihkongestivnim zatajenjem srca. On takođe koristu u niskim dozama za kontroluhipertenzije.[4][5][6][7]

Reference

[uredi |uredi kod]
  1. ↑Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ↑Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ↑Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. ↑Dunn CJ, Fitton A, Brogden RN: Torasemide. An update of its pharmacological properties and therapeutic efficacy. Drugs. 1995 Jan;49(1):121-42.PMID7705212
  5. ↑FDA approved new drug bulletin: torsemide (Demadex), trimetrexate glucuronate (neuTrexin). RN. 1994 May;57(5):53-6.PMID8197389
  6. ↑Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. PMID 21059682. 
  7. ↑Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. PMID 18048412. 

Vanjske veze

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Portal Medicina
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Torasemid naWikimedijinoj ostavi

Šablon:Diuretici

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