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Tirotropinski receptor

Uredi veze

Izvor: Wikipedija

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Tirotropinski receptor

Identifikatori

Simboli

TSHR; LGR3; MGC75129; hTSHR-I

Vanjski ID

OMIM: 603372MGI: 98849HomoloGene: 315IUPHAR:TSHGeneCards:TSHR Gene

Ontologija gena
Molekularna funkcija	•receptorska aktivnost•aktivnost tirotropinskog receptora•vezivanje proteina
Celularna komponenta	•ćelijska membrana•integralno sa ćelijskom membranom
Biološki proces	•prenos signala•G-proteinska signalizacija, spregnuta sa cikličnim nukleotidnim sekundarnim glasnikom•G-protein signalizacija, put aktiviranja adenilat ciklaze•ćelija-ćelija signalizacija•pozitivna regulacija ćelijske proliferacije•lokomotorno ponašanje odraslih osoba•regulacija lokomocije•pozitivna regulacija veličine tela

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

RefSeq (mRNA)

RefSeq (protein)

Lokacija (UCSC)

Chr 14:
80.49 - 80.68 Mb

Chr 12:
91.81 - 91.95 Mb

PubMed pretraga

[1]

[2]

Tirotropinski receptor (iliTSH receptor) je receptor koji odgovara natireostimulišući hormon (takođe poznat kao "tirotropin", i stimuliše produkcijutiroksina (T4) itrijodotironina (T3). TSH receptor je član familijG protein-spregnutih receptora,integralnih membranskih proteina^[1]. Ovaj receptor je spregnut saG_s.^[2]

One je prvenstveno nađen na površinitiroidnih epitelskih ćelija.

Povezano

[uredi |uredi kod]

Gravesova bolest

Reference

[uredi |uredi kod]

↑Farid NR, Szkudlinski MW (2004). „Minireview: structural and functional evolution of the thyrotropin receptor”. Endocrinology 145 (9): 4048–57. DOI:10.1210/en.2004-0437. PMID 15231707.
↑Calebiro D, Nikolaev VO, Lohse MJ (July 2010). „Imaging of persistent cAMP signaling by internalized G protein-coupled receptors”. J. Mol. Endocrinol. 45 (1): 1–8. DOI:10.1677/JME-10-0014. PMID 20378719.

Literatura

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Führer D, Wonerow P, Willgerodt H, Paschke R (1998). „Identification of a new thyrotropin receptor germline mutation (Leu629Phe) in a family with neonatal onset of autosomal dominant nonautoimmune hyperthyroidism.”. J. Clin. Endocrinol. Metab. 82 (12): 4234–8. DOI:10.1210/jc.82.12.4234. PMID 9398746.
Farid NR, Kascur V, Balazs C (2000). „The human thyrotropin receptor is highly mutable: a review of gain-of-function mutations.”. Eur. J. Endocrinol. 143 (1): 25–30. DOI:10.1530/eje.0.1430025. PMID 10870027.
Szkudlinski MW, Fremont V, Ronin C, Weintraub BD (2002). „Thyroid-stimulating hormone and thyroid-stimulating hormone receptor structure-function relationships.”. Physiol. Rev. 82 (2): 473–502. DOI:10.1152/physrev.00031.2001. PMID 11917095.
Tonacchera M, Vitti P, De Servi M,et al. (2004). „Gain of function TSH receptor mutations and iodine deficiency: implications in iodine prophylaxis.”. J. Endocrinol. Invest. 26 (2 Suppl): 2–6. PMID 12762632.
Arturi F, Scarpelli D, Coco A,et al. (2004). „Thyrotropin receptor mutations and thyroid hyperfunctioning adenomas ten years after their first discovery: unresolved questions.”. Thyroid 13 (4): 341–3. DOI:10.1089/105072503321669811. PMID 12804102.
Vaidya B, Campbell V, Tripp JH,et al. (2004). „Premature birth and low birth weight associated with nonautoimmune hyperthyroidism due to an activating thyrotropin receptor gene mutation.”. Clin. Endocrinol. (Oxf) 60 (6): 711–8. DOI:10.1111/j.1365-2265.2004.02040.x. PMID 15163335.
Takeshita A, Nagayama Y, Fujiyama K,et al. (1992). „Molecular cloning and sequencing of an alternatively spliced form of the human thyrotropin receptor transcript.”. Biochem. Biophys. Res. Commun. 188 (3): 1214–9. DOI:10.1016/0006-291X(92)91360-3. PMID 1445355.
Graves PN, Tomer Y, Davies TF (1992). „Cloning and sequencing of a 1.3 KB variant of human thyrotropin receptor mRNA lacking the transmembrane domain.”. Biochem. Biophys. Res. Commun. 187 (2): 1135–43. DOI:10.1016/0006-291X(92)91315-H. PMID 1530609.
Loosfelt H, Pichon C, Jolivet A,et al. (1992). „Two-subunit structure of the human thyrotropin receptor.”. Proc. Natl. Acad. Sci. U.S.A. 89 (9): 3765–9. DOI:10.1073/pnas.89.9.3765. PMC 525571. PMID 1570295.
Nagayama Y, Russo D, Wadsworth HL,et al. (1991). „Eleven amino acids (Lys-201 to Lys-211) and 9 amino acids (Gly-222 to Leu-230) in the human thyrotropin receptor are involved in ligand binding.”. J. Biol. Chem. 266 (23): 14926–30. PMID 1651314.
Murakami M, Mori M (1990). „Identification of immunogenic regions in human thyrotropin receptor for immunoglobulin G of patients with Graves' disease.”. Biochem. Biophys. Res. Commun. 171 (1): 512–8. DOI:10.1016/0006-291X(90)91423-P. PMID 1697467.
Heldin NE, Gustavsson B, Westermark K, Westermark B (1992). „A somatic point mutation in a putative ligand binding domain of the TSH receptor in a patient with autoimmune hyperthyroidism.”. J. Clin. Endocrinol. Metab. 73 (6): 1374–6. DOI:10.1210/jcem-73-6-1374. PMID 1955520.
Libert F, Passage E, Lefort A,et al. (1991). „Localization of human thyrotropin receptor gene to chromosome region 14q3 by in situ hybridization.”. Cytogenet. Cell Genet. 54 (1-2): 82–3. DOI:10.1159/000132964. PMID 2249482.
Frazier AL, Robbins LS, Stork PJ,et al. (1991). „Isolation of TSH and LH/CG receptor cDNAs from human thyroid: regulation by tissue specific splicing.”. Mol. Endocrinol. 4 (8): 1264–76. DOI:10.1210/mend-4-8-1264. PMID 2293030.
Misrahi M, Loosfelt H, Atger M,et al. (1990). „Cloning, sequencing and expression of human TSH receptor.”. Biochem. Biophys. Res. Commun. 166 (1): 394–403. DOI:10.1016/0006-291X(90)91958-U. PMID 2302212.
Nagayama Y, Kaufman KD, Seto P, Rapoport B (1990). „Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor.”. Biochem. Biophys. Res. Commun. 165 (3): 1184–90. DOI:10.1016/0006-291X(89)92727-7. PMID 2558651.
Libert F, Lefort A, Gerard C,et al. (1990). „Cloning, sequencing and expression of the human thyrotropin (TSH) receptor: evidence for binding of autoantibodies.”. Biochem. Biophys. Res. Commun. 165 (3): 1250–5. DOI:10.1016/0006-291X(89)92736-8. PMID 2610690.
Cuddihy RM, Bryant WP, Bahn RS (1996). „Normal function in vivo of a homozygotic polymorphism in the human thyrotropin receptor.”. Thyroid 5 (4): 255–7. DOI:10.1089/thy.1995.5.255. PMID 7488864.
Bahn RS, Dutton CM, Heufelder AE, Sarkar G (1994). „A genomic point mutation in the extracellular domain of the thyrotropin receptor in patients with Graves' ophthalmopathy.”. J. Clin. Endocrinol. Metab. 78 (2): 256–60. DOI:10.1210/jc.78.2.256. PMID 7508946.
Sunthornthepvarakui T, Gottschalk ME, Hayashi Y, Refetoff S (1995). „Brief report: resistance to thyrotropin caused by mutations in the thyrotropin-receptor gene.”. N. Engl. J. Med. 332 (3): 155–60. DOI:10.1056/NEJM199501193320305. PMID 7528344.

Vanjske veze

[uredi |uredi kod]

„Glycoprotein Hormone Receptors: TSH”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano izoriginala na datum 2013-11-01.
MeSHThyrotropin+Receptors
GRIS Arhivirano 2006-10-16 naWayback Machine-u

Transmembranski receptor:G protein spregnuti receptori

Klasa A:Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A,B,D) • α2 (A,B,C) • β1 • β2 • β3
Purinski	Adenozinski (A1,A2A,A2B,A3) • P2Y (1,2,4,5,6,8,9,10,11,12,13,14)
Serotoninski	(svi osim 5-HT3)5-HT1 (A,B,D,E,F) • 5-HT2 (A,B,C) • 5-HT (4,5A,6,7)
Drugi	Acetilholin (M1,M2,M3,M4,M5) • Dopamin (D1,D2,D3,D4,D5) • Histamin (H1,H2,H3,H4) • Melatonin (1A,1B,1C) • TAAR (1,2,3,5,6,8,9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1,2) • LTB4 (1,2) • FPRL1 • OXE • Prostaglandin (DP (1,2),EP (1,2,3,4),FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1,CB2,GPR (18,55,119)) • EBI2 • Estrogen • Slobodna masna kiselina (1,2,3,4) • Laktat • Lizofosfatidna kiselina (1,2,3,4,5,6) • Lizofosfolipid (1,2,3,4,5,6,7,8) • Niacin (1,2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1,2,3,4,5) • Sukcinat

Peptid

Neuropeptidni

B/W (1,2) • FF (1,2) • S • Y (1,2,4,5) • Neuromedin (B,U (1,2)) • Neurotenzin (1,2)

Drugi

Anafilatoksin (C3a,C5a) • Angiotenzin (1,2) • Apelin • Bombezin (BRS3,GRPR,NMBR) • Bradikinin (B1,B2) • Hemokin • Holecistokinin (A,B) • Endotelin (A,B) • Formil peptid (1,2,3) • FSH • Galanin (1,2,3) • GHB receptor • Gonadotropin-oslobađajući hormon (1,2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1,1L,D,E,F,G,X1,X2,X3,X4) • Melanokortin (1,2,3,4,5) • MCHR (1,2) • Motilin • Opioidni (δ,κ,μ,Nociceptin &ζ, ali neσ) • Oreksin (1,2) • Oksitocin • Prokineticin (1,2) • Prolaktin-oslobađajući peptid • Relaksin (1,2,3,4) • Somatostatin (1,2,3,4,5) • Tahikinin (1,2,3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A,1B,2)

Razno

Orfan	GPR (1,3,4,6,12,15,17,18,19,20,21,22,23,25,26,27,31,32,33,34,35,37,39,42,44,45,50,52,55,61,62,63,65,68,75,77,78,81,82,83,84,85,87,88,92,101,103,109A,109B,119,120,132,135,137B,139,141,142,146,148,149,150,151,152,153,160,161,162,171,173,174,176,177,182,183)
Drugi	Adrenomedulin • Mirisni • Opsin (3,4,5,1LW,1MW,1SW,RGR,RRH) • Proteazom-aktivirani (1,2,3,4) • SREB (1,2,3)

Klasa B:Sekretinu slični

Orfan

GPR (56,64,97,98,110,111,112,113,114,115,116,123,124,125,126,128,133,143,144,155,157)

Drugi

Moždano specifični angiogenezni inhibitor (1,2,3) • Cadherin (1,2,3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1,2) • EMR (1,2,3) • Glukagon (GR,GIPR,GLP1R,GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1,2,3,ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1,2) • Sekretin • Vazoaktivni intestinalni peptid (1,2)

Klasa C:Metabotropni
glutamat /feromon

Ukus	TAS1R (1,2,3) • TAS2R (1,3,4,5,8,9,10,12,13,14,16,19,20,30,31,38,39,40,41,42,43,45,46,50)
Drugi	Kalcijum-detektujući receptor • GABA B (1,2) • Glutamatni receptor (Metabotropni glutamat (1,2,3,4,5,6,7,8)) • GPRC6A • GPR (156,158,179) • RAIG (1,2,3,4)

Klasa F:
Frizzled /Zaglađeni

Uvojiti	Frizzled (1,2,3,4,5,6,7,8,9,10)
Zaglađeni	Zaglađeni

B trdu:peptidi (nrpl/grfl/cytl/horl),receptori (lgic,enzr,gprc,igsr,intg,nrpr/grfr/cytr),itra (adap,gbpr,mapk),calc,lipd, signalni putevi (hedp,wntp,tgfp+mapp,notp,jakp,fsap,hipp,tlrp)

Neuropeptidni receptori

Hormonski receptori

Hipotalamusni	CRH -FSH -LHRH -TRH -Somatostatin
Hipofizni	Vazopresin (1A,1B,2) -Oksitocin -LHCG -Tip I citokinski receptor (GH,Prolaktin) -TSH
Drugi	Atrijalni natriuretski faktor (NPR1,NPR2,NPR3) -Kalcitonin -Holecistokinin (A,B) -VIP

Opioidni receptori

Delta -Kapa -Mi -Sigma (1,2) -Nociceptin

Drugi neuropeptidni receptori

Angiotenzin -Bradikinin (B1,B2) /Tahikinin (TACR1) -Kalcitoninu sličan -Galanin -GPCR neuropeptid (B/W,FF,S,Y) -Neurotenzin

B trdu:peptidi (nrpl/grfl/cytl/horl),receptori (lgic,enzr,gprc,igsr,intg,nrpr/grfr/cytr),itra (adap,gbpr,mapk),calc,lipd, signalni putevi (hedp,wntp,tgfp+mapp,notp,jakp,fsap,hipp,tlrp)

Izvor:https://sh.wikipedia.org/w/index.php?title=Tirotropinski_receptor&oldid=42509155

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