Movatterモバイル変換


[0]ホーム

URL:


Prijeđi na sadržaj
Wikipedija
Pretraga

Tipranavir

Izvor: Wikipedija
Tipranavir
Klinički podaci
Robne markeAptivus, Aptivus (Boehringer Ingelheim)
AHFS/Drugs.comMonografija
Identifikatori
CAS broj174484-41-4
ATC kodJ05AE09
PubChem[1][2]65027
DrugBankDB00932
ChemSpider[3]58539
ChEMBL[4]CHEMBL183041 DaY
Hemijski podaci
FormulaC31H33F3N2O5S 
Mol. masa602,664
SMILESeMolekuli &PubHem
InChI
InChI=1S/C31H33F3N2O5S/c1-3-16-30(17-15-21-9-6-5-7-10-21)19-26(37)28(29(38)41-30)25(4-2)22-11-8-12-24(18-22)36-42(39,40)27-14-13-23(20-35-27)31(32,33)34/h5-14,18,20,25,36,38H,3-4,15-17,19H2,1-2H3/t25-,30-/m1/s1
Key: NZPXPXAGXYTROM-FYBSXPHGSA-N DaY
Farmakokinetički podaci
Poluvreme eliminacije5-6 h
Farmakoinformacioni podaci
Trudnoća?
Pravni status
Način primeneOralno

Tipranavir jeorgansko jedinjenje, koje sadrži 31atomugljenika i imamolekulsku masu od 602,664Da.[5][6][7][8][9][10]

Osobine

[uredi |uredi kod]
OsobinaVrednost
Broj akceptora vodonika6
Broj donora vodonika2
Broj rotacionih veza12
Particioni koeficijent[11] (ALogP)7,4
Rastvorljivost[12] (logS, log(mol/L))-9,6
Polarna površina[13] (PSA,Å2)114,0

Reference

[uredi |uredi kod]
  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  5. Doyon L, Tremblay S, Bourgon L, Wardrop E, Cordingley MG: Selection and characterization of HIV-1 showing reduced susceptibility to the non-peptidic protease inhibitor tipranavir. Antiviral Res. 2005 Oct;68(1):27-35.PMID16122817
  6. Tipranavir: PNU 140690, tipranivir. Drugs R D. 2006;7(1):55-62.PMID16620137
  7. Temesgen Z, Feinberg J: Tipranavir: a new option for the treatment of drug-resistant HIV infection. Clin Infect Dis. 2007 Sep 15;45(6):761-9. Epub 2007 Aug 7.PMID17712762
  8. Luna B, Townsend MU: Tipranavir: the first nonpeptidic protease inhibitor for the treatment of protease resistance. Clin Ther. 2007 Nov;29(11):2309-18.PMID18158073
  9. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. DOI:10.1093/nar/gkq1126. PMC 3013709. PMID 21059682.  edit
  10. David S. Wishart, Craig Knox, An Chi Guo, Dean Cheng, Savita Shrivastava, Dan Tzur, Bijaya Gautam, and Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. DOI:10.1093/nar/gkm958. PMC 2238889. PMID 18048412.  edit
  11. Ghose, A.K., Viswanadhan V.N., and Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A 102: 3762-3772. DOI:10.1021/jp980230o. 
  12. Tetko IV, Tanchuk VY, Kasheva TN, Villa AE. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488-1493. DOI:10.1021/ci000392t. PMID 11749573.  edit
  13. Ertl P., Rohde B., Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714-3717. DOI:10.1021/jm000942e. PMID 11020286.  edit

Literatura

[uredi |uredi kod]

Vanjske veze

[uredi |uredi kod]
Portal Medicina
Portal Hemija
Tipranavir naWikimedijinoj ostavi
Izvor:https://sh.wikipedia.org/w/index.php?title=Tipranavir&oldid=42300574
Kategorije:

[8]ページ先頭

©2009-2026 Movatter.jp