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TAS2R38

Uredi veze

Izvor: Wikipedija

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Receptor ukusa tip 2 član 38

Identifikatori

Simboli

TAS2R38; PTC; T2R38; T2R61

Vanjski ID

OMIM: 607751MGI: 2681306HomoloGene: 47976IUPHAR:GeneCards:TAS2R38 Gene

Ontologija gena
Molekularna funkcija	•aktivnost receptora ukusa
Celularna komponenta	•integralno sa membranom
Biološki proces	•signalni put G-protein spregnutog receptora

Ortolozi

Vrsta

Čovek

Miš

RefSeq (mRNA)

RefSeq (protein)

Lokacija (UCSC)

Chr 7:
141.67 - 141.67 Mb

Chr 6:
40.56 - 40.56 Mb

PubMed pretraga

[1]

[2]

Receptor ukusa tip 2 član 38 jeprotein koji je kod ljudi kodiranTAS2R38genom. TAS2R38 je receptor gorkog ukusa. Različitigenotipi ovog receptora utiču na sposobnost prepoznavanja ukusa 6-n-propiltiouracila (PROP)^[1] ifeniltiokarbamida (PTC).^[2]^[3] Though it has often been proposed that varying taste receptor genotypes could influence tasting ability, TAS2R38 is one of the only taste receptors shown to have this function.^[4]

Prenos signala

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Kao i kod svih TAS2R proteina, TAS2R38 koristi G-proteingustducin kao svoj primarni metodprenosa signala. Jedinice α i βγ su esencijalne za prenos signala ukusa.^[5]

Reference

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↑Duffy VB, Davidson AC, Kidd JR, Kidd KK, Speed WC, Pakstis AJ, Reed DR, Snyder DJ, Bartoshuk LM (2004). „Bitter Receptor Gene (TAS2R38), 6-n-Propylthiouracil (PROP) Bitterness and Alcohol Intake”. Alcoholism, clinical and experimental research 28 (11): 1629–1637. DOI:10.1097/01.ALC.0000145789.55183.D4. PMC 1397913. PMID 15547448.
↑Prodi DA, Drayna D, Forabosco P, Palmas MA, Maestrale GB, Piras D, Pirastu M, Angius A (2004). „Bitter Taste Study in a Sardinian Genetic Isolate Supports the Association of Phenylthiocarbamide Sensitivity to the TAS2R38 Bitter Receptor Gene”. Chemical Senses 29 (8): 697–702. DOI:10.1093/chemse/bjh074. PMID 15466815.
↑Kim UK, Drayna D (2004). „Genetics of individual differences in bitter taste perception: Lessons from the PTC gene”. Clinical Genetics 67 (4): 275–280. DOI:10.1111/j.1399-0004.2004.00361.x. PMID 15733260.
↑Bachmanov AA, Beauchamp GK (2007). „Taste Receptor Genes”. Annual Review of Nutrition 27: 389–414. DOI:10.1146/annurev.nutr.26.061505.111329. PMC 2721271. PMID 17444812.
↑Margolskee RF (2001). „Molecular Mechanisms of Bitter and Sweet Taste Transduction”. Journal of Biological Chemistry 277 (1): 1–4. DOI:10.1074/jbc.R100054200. PMID 11696554.

Literatura

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Montmayeur JP, Matsunami H (2002). „Receptors for bitter and sweet taste”. Curr. Opin. Neurobiol. 12 (4): 366–71. DOI:10.1016/S0959-4388(02)00345-8. PMID 12139982.
Anne-Spence M, Falk CT, Neiswanger K,et al. (1984). „Estimating the recombination frequency for the PTC-Kell linkage”. Hum. Genet. 67 (2): 183–6. DOI:10.1007/BF00272997. PMID 6745938.
Bufe B, Hofmann T, Krautwurst D,et al. (2002). „The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides”. Nat. Genet. 32 (3): 397–401. DOI:10.1038/ng1014. PMID 12379855.
Strausberg RL, Feingold EA, Grouse LH,et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Zhang Y, Hoon MA, Chandrashekar J,et al. (2003). „Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways”. Cell 112 (3): 293–301. DOI:10.1016/S0092-8674(03)00071-0. PMID 12581520.
Conte C, Ebeling M, Marcuz A,et al. (2003). „Identification and characterization of human taste receptor genes belonging to the TAS2R family”. Cytogenet. Genome Res. 98 (1): 45–53. DOI:10.1159/000068546. PMID 12584440.
Scherer SW, Cheung J, MacDonald JR,et al. (2003). „Human Chromosome 7: DNA Sequence and Biology”. Science 300 (5620): 767–72. DOI:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Pronin AN, Tang H, Connor J, Keung W (2005). „Identification of ligands for two human bitter T2R receptors”. Chem. Senses 29 (7): 583–93. DOI:10.1093/chemse/bjh064. PMID 15337684.
Gerhard DS, Wagner L, Feingold EA,et al. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Fischer A, Gilad Y, Man O, Pääbo S (2005). „Evolution of bitter taste receptors in humans and apes”. Mol. Biol. Evol. 22 (3): 432–6. DOI:10.1093/molbev/msi027. PMID 15496549.
Go Y, Satta Y, Takenaka O, Takahata N (2006). „Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates”. Genetics 170 (1): 313–26. DOI:10.1534/genetics.104.037523. PMC 1449719. PMID 15744053.

Vanjske veze

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Povezano

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Receptor ukusa

Transmembranski receptor:G protein spregnuti receptori

Klasa A:Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A,B,D) • α2 (A,B,C) • β1 • β2 • β3
Purinski	Adenozinski (A1,A2A,A2B,A3) • P2Y (1,2,4,5,6,8,9,10,11,12,13,14)
Serotoninski	(svi osim 5-HT3)5-HT1 (A,B,D,E,F) • 5-HT2 (A,B,C) • 5-HT (4,5A,6,7)
Drugi	Acetilholin (M1,M2,M3,M4,M5) • Dopamin (D1,D2,D3,D4,D5) • Histamin (H1,H2,H3,H4) • Melatonin (1A,1B,1C) • TAAR (1,2,3,5,6,8,9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1,2) • LTB4 (1,2) • FPRL1 • OXE • Prostaglandin (DP (1,2),EP (1,2,3,4),FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1,CB2,GPR (18,55,119)) • EBI2 • Estrogen • Slobodna masna kiselina (1,2,3,4) • Laktat • Lizofosfatidna kiselina (1,2,3,4,5,6) • Lizofosfolipid (1,2,3,4,5,6,7,8) • Niacin (1,2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1,2,3,4,5) • Sukcinat

Peptid

Neuropeptidni

B/W (1,2) • FF (1,2) • S • Y (1,2,4,5) • Neuromedin (B,U (1,2)) • Neurotenzin (1,2)

Drugi

Anafilatoksin (C3a,C5a) • Angiotenzin (1,2) • Apelin • Bombezin (BRS3,GRPR,NMBR) • Bradikinin (B1,B2) • Hemokin • Holecistokinin (A,B) • Endotelin (A,B) • Formil peptid (1,2,3) • FSH • Galanin (1,2,3) • GHB receptor • Gonadotropin-oslobađajući hormon (1,2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1,1L,D,E,F,G,X1,X2,X3,X4) • Melanokortin (1,2,3,4,5) • MCHR (1,2) • Motilin • Opioidni (δ,κ,μ,Nociceptin &ζ, ali neσ) • Oreksin (1,2) • Oksitocin • Prokineticin (1,2) • Prolaktin-oslobađajući peptid • Relaksin (1,2,3,4) • Somatostatin (1,2,3,4,5) • Tahikinin (1,2,3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A,1B,2)

Razno

Orfan	GPR (1,3,4,6,12,15,17,18,19,20,21,22,23,25,26,27,31,32,33,34,35,37,39,42,44,45,50,52,55,61,62,63,65,68,75,77,78,81,82,83,84,85,87,88,92,101,103,109A,109B,119,120,132,135,137B,139,141,142,146,148,149,150,151,152,153,160,161,162,171,173,174,176,177,182,183)
Drugi	Adrenomedulin • Mirisni • Opsin (3,4,5,1LW,1MW,1SW,RGR,RRH) • Proteazom-aktivirani (1,2,3,4) • SREB (1,2,3)

Klasa B:Sekretinu slični

Orfan

GPR (56,64,97,98,110,111,112,113,114,115,116,123,124,125,126,128,133,143,144,155,157)

Drugi

Moždano specifični angiogenezni inhibitor (1,2,3) • Cadherin (1,2,3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1,2) • EMR (1,2,3) • Glukagon (GR,GIPR,GLP1R,GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1,2,3,ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1,2) • Sekretin • Vazoaktivni intestinalni peptid (1,2)

Klasa C:Metabotropni
glutamat /feromon

Ukus	TAS1R (1,2,3) • TAS2R (1,3,4,5,8,9,10,12,13,14,16,19,20,30,31,38,39,40,41,42,43,45,46,50)
Drugi	Kalcijum-detektujući receptor • GABA B (1,2) • Glutamatni receptor (Metabotropni glutamat (1,2,3,4,5,6,7,8)) • GPRC6A • GPR (156,158,179) • RAIG (1,2,3,4)

Klasa F:
Frizzled /Zaglađeni

Uvojiti	Frizzled (1,2,3,4,5,6,7,8,9,10)
Zaglađeni	Zaglađeni

B trdu:peptidi (nrpl/grfl/cytl/horl),receptori (lgic,enzr,gprc,igsr,intg,nrpr/grfr/cytr),itra (adap,gbpr,mapk),calc,lipd, signalni putevi (hedp,wntp,tgfp+mapp,notp,jakp,fsap,hipp,tlrp)

Izvor:https://sh.wikipedia.org/w/index.php?title=TAS2R38&oldid=42509224

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