T-Plasminogeni aktivator (EC3.4.21.68,tkivni plazminogenski activator,plazminogenski aktivator, tkivni-tip,tkivni tip plazminogenskog aktivatora,tPA,t-PA) jeenzim.[1][2][3][4][5][6] Ovaj enzimkatalizuje sledećuhemijsku reakciju
- Specifično razlaganje Arg-Val veze uplazminogenu čime se formiraplazmin
Ova peptidaza je prisutna u širokom opsegu tipova tkiva, a posebno uendotelnim ćelijama.
- ↑Pennica, D., Holmes, W.E., Kohr, W.J., Harkins, R.N., Vehar, G.A., Ward, C.A., Bennett, W.F., Yelverton, E., Seeburg, P.H., Heyneker, H.L., Goeddel, D.V. and Collen, D. (1983). „Cloning and expression of human tissue-type plasminogen activator cDNA inE. coli”. Nature 301: 214-221. PMID 6337343.
- ↑Loskutoff, D.J. and Schleef, R.R. (1988). „Plasminogen activators and their inhibitors”. Methods Enzymol. 163: 293-302. PMID 3148826.
- ↑Petersen, L.C., Johannessen, M., Forster, D., Kumar, A. and Mulvihill, E. (1988). „The effect of polymerised fibrin on the catalytic activities of one-chain tissue-type plasminogen activator as revealed by an analogue resistant to plasmin cleavage”. Biochim. Biophys. Acta 952: 245-254. PMID 2962643.
- ↑Verheijen, J.H. (1988). „Tissue-type plasminogen activator and fast-acting plasminogen activator inhibitor in plasma”. Methods Enzymol. 163: 302-309. PMID 3148827.
- ↑Gerard, R.D. and Meidell, R.S. (1989). „Regulation of tissue plasminogen activator expression”. Annu. Rev. Physiol. 51: 245-262. PMID 2496643.
- ↑Collen, D., Lijnen, H. R. and Verstraete, M. (1990). „The fibrinolytic system and its disorders”. u: Handin, R.I., Lux, S.E. and Stossel, J.P.. Blood: Principles and Practice of Hematology (2nd izd.). Philadelphia: J.B.Lippincott Company. str. -.
- Collen, D., Lijnen, H. R. and Verstraete, M. (1990). „The fibrinolytic system and its disorders”. u: Handin, R.I., Lux, S.E. and Stossel, J.P.. Blood: Principles and Practice of Hematology (2nd izd.). Philadelphia: J.B.Lippincott Company. str. -.
