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Saredutant

Izvor: Wikipedija

Saredutant

(IUPAC) ime

N-[(2S)-4-(4-acetamido-4-phenylpiperidin-1-yl)- 2-(3,4-dichlorophenyl)butyl]-N-methylbenzamide

Klinički podaci

Identifikatori

CAS broj

nije dodeljen

PubChem^[1]^[2]

Hemijski podaci

C₃₁H₃₅N₃O₂

552.5345 g/mol

InChI
InChI=1S/C31H35Cl2N3O2/c1-23(37)34-31(27-11-7-4-8-12-27)16-19-36(20-17-31)18-15-26(25-13-14-28(32)29(33)21-25)22-35(2)30(38)24-9-5-3-6-10-24/h3-14,21,26H,15-20,22H2,1-2H3,(H,34,37)/t26-/m1/s1^Y Key: PGKXDIMONUAMFR-AREMUKBSSA-N^Y

Farmakoinformacioni podaci

Trudnoća

Saredutant (SR-48,968) jelek koji deluje kaoantagonist NK₂ receptora. Njega je razvioSanofi-Aventis kao noviantidepresant ianksiolitik. Lek je dosped do faze IIIkliničkih ispitivanja. Međutim, maja2009, Sanofi-Aventis je objavio svoje tromesečne rezultate i najavio prestanak rada na 14 projekata u razvoju, među kojima je bio saredutant za tretmankliničke depresije.^[5].

↑Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑„Letter to the stockholders of Sanofi-Aventis on May 2009”. Arhivirano izoriginala na datum 2010-12-21. Pristupljeno 2014-04-05.

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