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SB-649,868

Izvor: Wikipedija

SB-649,868

(IUPAC) ime

N-([(2S)-1-([5-(4-fluorofenil)-2-metil-4-tiazolil]karbonil)-2-piperidinil]metil)-4-benzofurankarboksamid

Klinički podaci

Identifikatori

nije dodeljen

PubChem^[1]^[2]

Hemijski podaci

C₂₆H₂₄F N₃O₃S

477,549 g/mol (slobodna baza)

eMolekuli &PubHem

InChI
InChI=1S/C26H24FN3O3S/c1-16-29-23(24(34-16)17-8-10-18(27)11-9-17)26(32)30-13-3-2-5-19(30)15-28-25(31)21-6-4-7-22-20(21)12-14-33-22/h4,6-12,14,19H,2-3,5,13,15H2,1H3,(H,28,31)/t19-/m0/s1^Y Key: ZJXIUGNEAIHSBI-IBGZPJMESA-N^Y

Farmakoinformacioni podaci

?

SB-649,868 je antagonistoreksinskog receptora u razvoju od strane kompanijeGlaksoSmitKlajn. Ovaj lek je u fazi 2 kliničkih ispitivanja za poremećaje spavanja.^[4]

Ovaj lek je sličanACT-078573, koji je razio Aktelion. GlaksoSmitKlajn je prekinuo dalja klinička ispitivanja almoreksanta zbog nuspojava.^[5]

Reference

[uredi |uredi kod]

↑Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑„Clinical trials to evaluate the effects of SB-649868 (10, 30 mg and 60 mg) on subjects with primary insomnia”.
↑„Almorexant in Adult Subjects With Chronic Primary Insomnia (RESTORA 1), ClinicalTrials.gov”. Pristupljeno 3. 02. 2010.

Vanjske veze

[uredi |uredi kod]

	Portal Medicina
	Portal Hemija

p
r
u

Hipnotici/sedativi (N05C)

GABA_A receptor

Ultra kratkotrajni	Metoheksital •Tiamilal •Tiopental
Kratko/srednje trajni	Alobarbital •Amobarbital •Aprobarbital •Butobarbital •Pentobarbital •Sekobarbital •Talbutal
Dugotrajni	Barbital •Mefobarbital •Fenobarbital
Negrupisani	Ciklobarbital •Etalobarbital •Heptabarbital •Heksobarbital •Proksibarbal •Reposal •Vinilbital •Vinbarbital

Kratkotrajni	Brotizolam •Cinolazepam •Doksefazepam •Loprazolam •Midazolam •Triazolam
Intermedijerno trajni	Estazolam •Flunitrazepam •Lormetazepam •Nimetazepam •Temazepam
Dugotrajni	Flurazepam •Flutoprazepam •Nitrazepam •Kvazepam

Dialkil-fenoli

Fospropofol •Propofol •Timol

Nebenzodiazepini

CL-218,872 •Eszopiklon •Indiplon •Nekopidem •Pazinaklon •ROD-188 •Saripidem •Suproklon •Suriklon •SX-3228 •U-89843A •U-90042 •Zaleplon •Zolpidem •Zopiklon

Glutetimid •Metiprilon •Piritildion •Piperidion

Aflokvalon •Klorokvalon •Diprokvalon •Etakvalon •Mebrokvalon •Meklokvalon •Metakvalon •Metilmetakvalon

Neuroaktivni
steroidi

Acebrokol •Alopregnanolon •Alfadolon •Alfaksolon •Eltanolon •Ganaksolon •Hidroksidion •Minaksolon •Org 20599 •Org 21465 •Tetrahidrodeoksi-kortikosteron

Alfa-2 adrenergički
receptor

Alfa-adrenergični agonisti	4-NEMD •Klonidin •Deksmedetomidin •Lofeksidin •Medetomidin •Romifidin •Tizanidin •Ksilazin

Melatoninski receptor

Melatonin	Agomelatin •Melatonin •Ramelteon •Tasimelteon

Histaminski receptor &
Acetilholinski receptor

Antihistamini & Antiholinergici	Amitriptilin •Dimenhidrinat •Doksilamin •Hidroksizin •Difenhidramin •Bromodifenhidramin •Karbinoksamin •Doksepin •Esmirtazapin •Orfenadrin •Mianserin •Mirtazapin •Feniltoloksamin •Propiomazin •Pirilamin •Skopolamin

5-HT_2A &
α₁- adrenergički

Selektivni5-HT_2A &α₁-adrenergički antagonisti	Etoperidon •Nefazodon •Niaprazin •Trazodon

GABA_B receptor /
GHB receptor

GHB Tip	1,4-Butandiol •Acebuterna kiselina •GABOB •Gama-hidroksibuterna kiselina •GBL •gama-Valerolakton

Oreksinski receptori

Oreksinski antagonisti	Almoreksant •SB-334,867 •SB-408,124 •SB-649,868 •TCS-OX2-29

Drugi receptori/
negrupisani

Aldehidi	Acetilglicinamid hloral hidrat •Hloral hidrat •Hloralodol •Dihloralfenazon •Paraldehid •Petrihloral
Alkini	Centalun •Ethlorvinol •Etinamat •Heksapropimat •Metilpentinol
Karbamati	Meprobamat •Karisoprodol •Tibamat •Metokarbamol •Procimat
Drugi	2-Metil-2-butanol •Acekarbromal •Acetofenon •Apronal •Bromidi •Bromizoval •Karbromal •Hloralosa •Klometiazol •Embutramid •Etomidat •Evoksin •Fenadiazol •Gaboksadol •Loreklezol •Mefenoksalon •Sulfonmetan •Trihloroetanol •Triklofos •Valerian •Valnoktamid

^#WHO-EM.^‡Povučeni sa tržišta.Kliničko ispitivanje:^†Faza III.^§Nikad do faze III

dsrd (o,d,b,p,a,s),spes,spvo

proc, lek(N5A/5B/5C/6A/6B/6D)

Šablon:Neuropeptidni ligandi

Izvor:https://sh.wikipedia.org/w/index.php?title=SB-649,868&oldid=42275369

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