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S1PR1

Uredi veze

Izvor: Wikipedija

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Sfingozin-1-fosfatni receptor 1

Struktura SIPR1-lizozim fuzije3v2y^[1]

Dostupne strukture

3V2W,3V2Y

Identifikatori

Simboli

S1PR1; CD363; CHEDG1; D1S3362; ECGF1; EDG-1; EDG1; S1P1

Vanjski ID

OMIM: 601974MGI: 1096355HomoloGene: 1071IUPHAR:S₁P₁GeneCards:S1PR1 Gene

Ontologija gena
Molekularna funkcija	•aktivnost G-protein spregnutog receptora•aktivnost sfingozin-1-fosfat receptora•vezivanje sfingolipida
Celularna komponenta	•ćelijska membrana•spoljašnja strana ćelijske membrane•integralno sa membranom
Biološki proces	•angiogeneza•ćelijska adhezija•signalni put G-protein spregnutog receptora

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

RefSeq (mRNA)

RefSeq (protein)

Lokacija (UCSC)

Chr 1:
101.7 - 101.71 Mb

Chr 3:
115.41 - 115.42 Mb

PubMed pretraga

[1]

[2]

S1PR1 (sfingozin-1-fosfatni receptor 1,S1P₁,EDG1, endotelni diferencijacioni gen 1) jeprotein koji je kod ljudi kodiranS1PR1genom. S1P₁ jeG protein spregnuti receptor za koji se vezuje lipidni signalni molekulsfingozin-1-fosfat (S1P).

Funkcija

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Ovaj protein je visoko izražen uendotelnim ćelijama. On vezuje sfingozin-1-fosfat sa visokim afinitetom i specifičnošću, i smatra se da učestvuje u procesima koji regulišu diferencijaciju endotelnih ćelija. Aktivacija ovog receptora indukuje međućelijskuadheziju.^[2]

Interakcije

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S1PR1 formirainterakcije sa5-HT1A receptorom,^[3]GNAI1^[4] iGNAI3.^[4]

Reference

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↑Hanson, M. A.; Roth, C. B.; Jo, E.; Griffith, M. T.; Scott, F. L.; Reinhart, G.; Desale, H.; Clemons, B. i dr.. (2012). „Crystal Structure of a Lipid G Protein-Coupled Receptor”. Science 335 (6070): 851. DOI:10.1126/science.1215904.
↑„Entrez Gene: EDG1 endothelial differentiation, sphingolipid G-protein-coupled receptor, 1”.
↑Salim, Kamran; Fenton Tim, Bacha Jamil, Urien-Rodriguez Hector, Bonnert Tim, Skynner Heather A, Watts Emma, Kerby Julie, Heald Anne, Beer Margaret, McAllister George, Guest Paul C (May 2002). „Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation”. J. Biol. Chem. (United States) 277 (18): 15482–5. DOI:10.1074/jbc.M201539200. ISSN 0021-9258. PMID 11854302.
↑^4,0^4,1Lee, M J; Evans M, Hla T (May 1996). „The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway”. J. Biol. Chem. (UNITED STATES) 271 (19): 11272–9. DOI:10.1074/jbc.271.19.11272. ISSN 0021-9258. PMID 8626678.

Literatura

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Spiegel S (2000). „Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors.”. Ann. N. Y. Acad. Sci. 905: 54–60. DOI:10.1111/j.1749-6632.2000.tb06537.x. PMID 10818441.
Igarashi Y (2002). „[Current studies on a novel lipid mediator, sphingosine 1-phosphate, and its receptors]”. Tanpakushitsu Kakusan Koso 47 (4 Suppl): 476–9. PMID 11915345.
Takuwa Y (2002). „[Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors]”. Tanpakushitsu Kakusan Koso 47 (4 Suppl): 496–502. PMID 11915348.
Takuwa Y, Takuwa N, Sugimoto N (2003). „The Edg family G protein-coupled receptors for lysophospholipids: their signaling properties and biological activities.”. J. Biochem. 131 (6): 767–71. PMID 12038970.
Wang D, Zhao Z, Caperell-Grant A,et al. (2008). „S1P differentially regulates migration of human ovarian cancer and human ovarian surface epithelial cells.”. Mol Cancer Ther 7 (7): 1993–2002. PMID 18645009.
Hla T, Maciag T (1990). „An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors.”. J. Biol. Chem. 265 (16): 9308–13. PMID 2160972.
Lee MJ, Evans M, Hla T (1996). „The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway.”. J. Biol. Chem. 271 (19): 11272–9. DOI:10.1074/jbc.271.19.11272. PMID 8626678.
Bonaldo MF, Lennon G, Soares MB (1997). „Normalization and subtraction: two approaches to facilitate gene discovery.”. Genome Res. 6 (9): 791–806. DOI:10.1101/gr.6.9.791. PMID 8889548.
An S, Bleu T, Huang W,et al. (1998). „Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids.”. FEBS Lett. 417 (3): 279–82. DOI:10.1016/S0014-5793(97)01301-X. PMID 9409733.
Lee MJ, Van Brocklyn JR, Thangada S,et al. (1998). „Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1.”. Science 279 (5356): 1552–5. DOI:10.1126/science.279.5356.1552. PMID 9488656.
Lee MJ, Thangada S, Liu CH,et al. (1998). „Lysophosphatidic acid stimulates the G-protein-coupled receptor EDG-1 as a low affinity agonist.”. J. Biol. Chem. 273 (34): 22105–12. DOI:10.1074/jbc.273.34.22105. PMID 9705355.
Ancellin N, Hla T (1999). „Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5.”. J. Biol. Chem. 274 (27): 18997–9002. DOI:10.1074/jbc.274.27.18997. PMID 10383399.
Windh RT, Lee MJ, Hla T,et al. (1999). „Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins.”. J. Biol. Chem. 274 (39): 27351–8. DOI:10.1074/jbc.274.39.27351. PMID 10488065.
Lee MJ, Thangada S, Claffey KP,et al. (1999). „Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate.”. Cell 99 (3): 301–12. DOI:10.1016/S0092-8674(00)81661-X. PMID 10555146.
Igarashi J, Michel T (2000). „Agonist-modulated targeting of the EDG-1 receptor to plasmalemmal caveolae. eNOS activation by sphingosine 1-phosphate and the role of caveolin-1 in sphingolipid signal transduction.”. J. Biol. Chem. 275 (41): 32363–70. DOI:10.1074/jbc.M003075200. PMID 10921915.
Parrill AL, Wang D, Bautista DL,et al. (2001). „Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate.”. J. Biol. Chem. 275 (50): 39379–84. DOI:10.1074/jbc.M007680200. PMID 10982820.
Liu Y, Wada R, Yamashita T,et al. (2000). „Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation.”. J. Clin. Invest. 106 (8): 951–61. DOI:10.1172/JCI10905. PMC 314347. PMID 11032855.
Murphy WJ, Eizirik E, Johnson WE,et al. (2001). „Molecular phylogenetics and the origins of placental mammals.”. Nature 409 (6820): 614–8. DOI:10.1038/35054550. PMID 11214319.
Hobson JP, Rosenfeldt HM, Barak LS,et al. (2001). „Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility.”. Science 291 (5509): 1800–3. DOI:10.1126/science.1057559. PMID 11230698.
Lee MJ, Thangada S, Paik JH,et al. (2001). „Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis.”. Mol. Cell 8 (3): 693–704. DOI:10.1016/S1097-2765(01)00324-0. PMID 11583630.

Povezano

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Lizofosfolipidni receptor

Vanjske veze

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„Lysophospholipid Receptors: S₁P₁”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano izoriginala na datum 2015-01-07.
MeSHLysophospholipid+receptors

Transmembranski receptor:G protein spregnuti receptori

Klasa A:Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A,B,D) • α2 (A,B,C) • β1 • β2 • β3
Purinski	Adenozinski (A1,A2A,A2B,A3) • P2Y (1,2,4,5,6,8,9,10,11,12,13,14)
Serotoninski	(svi osim 5-HT3)5-HT1 (A,B,D,E,F) • 5-HT2 (A,B,C) • 5-HT (4,5A,6,7)
Drugi	Acetilholin (M1,M2,M3,M4,M5) • Dopamin (D1,D2,D3,D4,D5) • Histamin (H1,H2,H3,H4) • Melatonin (1A,1B,1C) • TAAR (1,2,3,5,6,8,9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1,2) • LTB4 (1,2) • FPRL1 • OXE • Prostaglandin (DP (1,2),EP (1,2,3,4),FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1,CB2,GPR (18,55,119)) • EBI2 • Estrogen • Slobodna masna kiselina (1,2,3,4) • Laktat • Lizofosfatidna kiselina (1,2,3,4,5,6) • Lizofosfolipid (1,2,3,4,5,6,7,8) • Niacin (1,2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1,2,3,4,5) • Sukcinat

Peptid

Neuropeptidni

B/W (1,2) • FF (1,2) • S • Y (1,2,4,5) • Neuromedin (B,U (1,2)) • Neurotenzin (1,2)

Drugi

Anafilatoksin (C3a,C5a) • Angiotenzin (1,2) • Apelin • Bombezin (BRS3,GRPR,NMBR) • Bradikinin (B1,B2) • Hemokin • Holecistokinin (A,B) • Endotelin (A,B) • Formil peptid (1,2,3) • FSH • Galanin (1,2,3) • GHB receptor • Gonadotropin-oslobađajući hormon (1,2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1,1L,D,E,F,G,X1,X2,X3,X4) • Melanokortin (1,2,3,4,5) • MCHR (1,2) • Motilin • Opioidni (δ,κ,μ,Nociceptin &ζ, ali neσ) • Oreksin (1,2) • Oksitocin • Prokineticin (1,2) • Prolaktin-oslobađajući peptid • Relaksin (1,2,3,4) • Somatostatin (1,2,3,4,5) • Tahikinin (1,2,3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A,1B,2)

Razno

Orfan	GPR (1,3,4,6,12,15,17,18,19,20,21,22,23,25,26,27,31,32,33,34,35,37,39,42,44,45,50,52,55,61,62,63,65,68,75,77,78,81,82,83,84,85,87,88,92,101,103,109A,109B,119,120,132,135,137B,139,141,142,146,148,149,150,151,152,153,160,161,162,171,173,174,176,177,182,183)
Drugi	Adrenomedulin • Mirisni • Opsin (3,4,5,1LW,1MW,1SW,RGR,RRH) • Proteazom-aktivirani (1,2,3,4) • SREB (1,2,3)

Klasa B:Sekretinu slični

Orfan

GPR (56,64,97,98,110,111,112,113,114,115,116,123,124,125,126,128,133,143,144,155,157)

Drugi

Moždano specifični angiogenezni inhibitor (1,2,3) • Cadherin (1,2,3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1,2) • EMR (1,2,3) • Glukagon (GR,GIPR,GLP1R,GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1,2,3,ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1,2) • Sekretin • Vazoaktivni intestinalni peptid (1,2)

Klasa C:Metabotropni
glutamat /feromon

Ukus	TAS1R (1,2,3) • TAS2R (1,3,4,5,8,9,10,12,13,14,16,19,20,30,31,38,39,40,41,42,43,45,46,50)
Drugi	Kalcijum-detektujući receptor • GABA B (1,2) • Glutamatni receptor (Metabotropni glutamat (1,2,3,4,5,6,7,8)) • GPRC6A • GPR (156,158,179) • RAIG (1,2,3,4)

Klasa F:
Frizzled /Zaglađeni

Uvojiti	Frizzled (1,2,3,4,5,6,7,8,9,10)
Zaglađeni	Zaglađeni

B trdu:peptidi (nrpl/grfl/cytl/horl),receptori (lgic,enzr,gprc,igsr,intg,nrpr/grfr/cytr),itra (adap,gbpr,mapk),calc,lipd, signalni putevi (hedp,wntp,tgfp+mapp,notp,jakp,fsap,hipp,tlrp)

Izvor:https://sh.wikipedia.org/w/index.php?title=S1PR1&oldid=42506941

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