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Piroksikam

Izvor: Wikipedija
Piroksikam
Klinički podaci
Robne markeAkten, Apo-Piroxicam, Artroxicam, Baxo
AHFS/Drugs.comMonografija
Identifikatori
CAS broj36322-90-4
ATC kodM01AC01 ,S01BC06
PubChem[1][2]5280452
DrugBankDB00554
ChemSpider[3]10442653
KEGG[4]C01608 DaY
ChEBICHEBI:8249 DaY
ChEMBL[5]CHEMBL527 DaY
Hemijski podaci
FormulaC15H13N3O4S 
Mol. masa331,346
SMILESeMolekuli &PubHem
InChI
InChI=1S/C15H13N3O4S/c1-18-13(15(20)17-12-8-4-5-9-16-12)14(19)10-6-2-3-7-11(10)23(18,21)22/h2-9,19H,1H3,(H,16,17,20)
Key: QYSPLQLAKJAUJT-UHFFFAOYSA-N DaY
Fizički podaci
Tačka topljenja198-200 °C (-130 °F)
Farmakokinetički podaci
Poluvreme eliminacije30 - 86 h
IzlučivanjeRenalno, fekalno
Farmakoinformacioni podaci
Trudnoća?
Pravni status
Način primeneOralno, rektalno

Piroksikam jeorgansko jedinjenje, koje sadrži 15atomaugljenika i imamolekulsku masu od 331,346Da.[6][7]

Osobine

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OsobinaVrednost
Broj akceptora vodonika5
Broj donora vodonika2
Broj rotacionih veza2
Particioni koeficijent[8] (ALogP)0,5
Rastvorljivost[9] (logS, log(mol/L))-3,3
Polarna površina[10] (PSA,Å2)108,0

Reference

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  1. ↑Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ↑Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ↑Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. ↑Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. ↑Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  6. ↑Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. DOI:10.1093/nar/gkq1126. PMC 3013709. PMID 21059682. 
  7. ↑David S. Wishart, Craig Knox, An Chi Guo, Dean Cheng, Savita Shrivastava, Dan Tzur, Bijaya Gautam, and Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. DOI:10.1093/nar/gkm958. PMC 2238889. PMID 18048412. 
  8. ↑Ghose, A.K., Viswanadhan V.N., and Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A 102: 3762-3772. DOI:10.1021/jp980230o. 
  9. ↑Tetko IV, Tanchuk VY, Kasheva TN, Villa AE. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488-1493. DOI:10.1021/ci000392t. PMID 11749573. 
  10. ↑Ertl P., Rohde B., Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714-3717. DOI:10.1021/jm000942e. PMID 11020286. 

Literatura

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Vanjske veze

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Portal Medicina
Portal Hemija
Piroksikam naWikimedijinoj ostavi
Salicilati
Arilalkanoinske kiseline
2-Arilpropionske kiseline
(profeni)
N-Arilantranilne kiseline
(fenaminske kiseline)
Pirazolidinski derivativi
Oksikami
COX-2 inhibitori
Sulfonanilidi
Proizvodi satopičkom primenom
COX-inhibirajući donori azot oksida
Drugi
Podebljani nazivi označavaju jedinjenja (spojeve) inicijalno razvijene u specifičnim grupama.†Lekovi povučeni sa tržišta.‡Veterinarski lekovi.
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