Movatterモバイル変換

[0]ホーム

Prijeđi na sadržaj

P2RY6

Uredi veze

Izvor: Wikipedija

edit

Pirimidinski receptor P2Y, G-protein spregnuti, 6

Identifikatori

Simboli

P2RY6; MGC15335; P2Y6

Vanjski ID

OMIM: 602451MGI: 2673874HomoloGene: 14289IUPHAR:P2Y₆GeneCards:P2RY6 Gene

Ontologija gena
Molekularna funkcija	•aktivnost rodopsinu-sličnog receptora•receptorska aktivnost•aktivnost purinskog nukleotidnog receptora, G-protein spregnutog•aktivnost UDP-aktiviranog nukleotidnog receptora
Celularna komponenta	•integralno sa ćelijskom membranom•membrana
Biološki proces	•prenos signal•G-proteinska signalizacija, spregnuta sa IP3 sekundarnim glasnikom (aktivacija fosfolipaze C)•transport transepitelnog hlorida

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

RefSeq (mRNA)

RefSeq (protein)

Lokacija (UCSC)

Chr 11:
72.65 - 72.69 Mb

Chr 7:
100.81 - 100.84 Mb

PubMed pretraga

[1]

[2]

P2RY6 (P2Y purinoceptor 6) jeprotein koji je kod ljudi kodiranP2RY6genom.^[1]^[2]

Protein kodiran ovim genom pripada familiji G-protein spregnutih receptora, koji su preferentno aktiviraninukleotidima adenozina iuridina. Ovaj receptor je responzivan naUDP, parcijalno responzivan naUTP iADP, i ne aktivira gaATP. Poznate su četiri transkriptne varijante koje kodiraju istu izoformu gena.^[2]

Povezano

[uredi |uredi kod]

P2Y receptor

Reference

[uredi |uredi kod]

↑Communi D, Parmentier M, Boeynaems JM (Aug 1996). „Cloning, functional expression and tissue distribution of the human P2Y6 receptor”. Biochem Biophys Res Commun 222 (2): 303–8. DOI:10.1006/bbrc.1996.0739. PMID 8670200.
↑^2,0^2,1„Entrez Gene: P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6”.

Literatura

[uredi |uredi kod]

Maier R, Glatz A, Mosbacher J, Bilbe G (1997). „Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues.”. Biochem. Biophys. Res. Commun. 237 (2): 297–302. DOI:10.1006/bbrc.1997.7135. PMID 9268704.
Somers GR, Hammet F, Woollatt E,et al. (1997). „Chromosomal localization of the human P2y6 purinoceptor gene and phylogenetic analysis of the P2y purinoceptor family.”. Genomics 44 (1): 127–30. DOI:10.1006/geno.1997.4841. PMID 9286708.
Maier R, Glatz A, Mosbacher J, Bilbe G (1997). „Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues.”. Biochem. Biophys. Res. Commun. 240 (2): 298–302. PMID 9412455.
Pidlaoan LV, Jin J, Sandhu AK,et al. (1998). „Colocalization of P2Y2 and P2Y6 receptor genes at human chromosome 11q13.3-14.1.”. Somat. Cell Mol. Genet. 23 (4): 291–6. DOI:10.1007/BF02674420. PMID 9542531.
Brinson AE, Harden TK (2001). „Differential regulation of the uridine nucleotide-activated P2Y4 and P2Y6 receptors. SER-333 and SER-334 in the carboxyl terminus are involved in agonist-dependent phosphorylation desensitization and internalization of the P2Y4 receptor.”. J. Biol. Chem. 276 (15): 11939–48. DOI:10.1074/jbc.M009909200. PMID 11114308.
Moore DJ, Chambers JK, Wahlin JP,et al. (2001). „Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study.”. Biochim. Biophys. Acta 1521 (1-3): 107–19. PMID 11690642.
Hou M, Harden TK, Kuhn CM,et al. (2002). „UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y(6) receptors.”. Am. J. Physiol. Heart Circ. Physiol. 282 (2): H784–92. DOI:10.1152/ajpheart.00997.2000. PMID 11788430.
Loomis WH, Namiki S, Ostrom RS,et al. (2003). „Hypertonic stress increases T cell interleukin-2 expression through a mechanism that involves ATP release, P2 receptor, and p38 MAPK activation.”. J. Biol. Chem. 278 (7): 4590–6. DOI:10.1074/jbc.M207868200. PMID 12464620.
Strausberg RL, Feingold EA, Grouse LH,et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kim SG, Soltysiak KA, Gao ZG,et al. (2003). „Tumor necrosis factor alpha-induced apoptosis in astrocytes is prevented by the activation of P2Y6, but not P2Y4 nucleotide receptors.”. Biochem. Pharmacol. 65 (6): 923–31. DOI:10.1016/S0006-2952(02)01614-3. PMID 12623123.
Schafer R, Sedehizade F, Welte T, Reiser G (2003). „ATP- and UTP-activated P2Y receptors differently regulate proliferation of human lung epithelial tumor cells.”. Am. J. Physiol. Lung Cell Mol. Physiol. 285 (2): L376–85. DOI:10.1152/ajplung.00447.2002. PMID 12691958.
Lee H, Choi BH, Suh BC,et al. (2003). „Attenuation of signal flow from P2Y6 receptor by protein kinase C-alpha in SK-N-BE(2)C human neuroblastoma cells.”. J. Neurochem. 85 (4): 1043–53. DOI:10.1046/j.1471-4159.2003.01761.x. PMID 12716436.
Gerhard DS, Wagner L, Feingold EA,et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wan D, Gong Y, Qin W,et al. (2004). „Large-scale cDNA transfection screening for genes related to cancer development and progression.”. Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. DOI:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
Cox MA, Gomes B, Palmer K,et al. (2005). „The pyrimidinergic P2Y6 receptor mediates a novel release of proinflammatory cytokines and chemokines in monocytic cells stimulated with UDP.”. Biochem. Biophys. Res. Commun. 330 (2): 467–73. DOI:10.1016/j.bbrc.2005.03.004. PMID 15796906.
Khine AA, Del Sorbo L, Vaschetto R,et al. (2006). „Human neutrophil peptides induce interleukin-8 production through the P2Y6 signaling pathway.”. Blood 107 (7): 2936–42. DOI:10.1182/blood-2005-06-2314. PMID 16322472.
Wihlborg AK, Balogh J, Wang L,et al. (2006). „Positive inotropic effects by uridine triphosphate (UTP) and uridine diphosphate (UDP) via P2Y2 and P2Y6 receptors on cardiomyocytes and release of UTP in man during myocardial infarction.”. Circ. Res. 98 (7): 970–6. DOI:10.1161/01.RES.0000217402.73402.cd. PMID 16543499.
Dulong S, Bernard K, Ehrenfeld J (2007). „Enhancement of P2Y6-induced Cl- secretion by IL-13 and modulation of SK4 channels activity in human bronchial cells.”. Cell. Physiol. Biochem. 20 (5): 483–94. DOI:10.1159/000107532. PMID 17762175.

Vanjske veze

[uredi |uredi kod]

„P2Y Receptors: P2Y₆”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano izoriginala na datum 2015-02-17.

Transmembranski receptor:G protein spregnuti receptori

Klasa A:Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A,B,D) • α2 (A,B,C) • β1 • β2 • β3
Purinski	Adenozinski (A1,A2A,A2B,A3) • P2Y (1,2,4,5,6,8,9,10,11,12,13,14)
Serotoninski	(svi osim 5-HT3)5-HT1 (A,B,D,E,F) • 5-HT2 (A,B,C) • 5-HT (4,5A,6,7)
Drugi	Acetilholin (M1,M2,M3,M4,M5) • Dopamin (D1,D2,D3,D4,D5) • Histamin (H1,H2,H3,H4) • Melatonin (1A,1B,1C) • TAAR (1,2,3,5,6,8,9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1,2) • LTB4 (1,2) • FPRL1 • OXE • Prostaglandin (DP (1,2),EP (1,2,3,4),FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1,CB2,GPR (18,55,119)) • EBI2 • Estrogen • Slobodna masna kiselina (1,2,3,4) • Laktat • Lizofosfatidna kiselina (1,2,3,4,5,6) • Lizofosfolipid (1,2,3,4,5,6,7,8) • Niacin (1,2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1,2,3,4,5) • Sukcinat

Peptid

Neuropeptidni

B/W (1,2) • FF (1,2) • S • Y (1,2,4,5) • Neuromedin (B,U (1,2)) • Neurotenzin (1,2)

Drugi

Anafilatoksin (C3a,C5a) • Angiotenzin (1,2) • Apelin • Bombezin (BRS3,GRPR,NMBR) • Bradikinin (B1,B2) • Hemokin • Holecistokinin (A,B) • Endotelin (A,B) • Formil peptid (1,2,3) • FSH • Galanin (1,2,3) • GHB receptor • Gonadotropin-oslobađajući hormon (1,2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1,1L,D,E,F,G,X1,X2,X3,X4) • Melanokortin (1,2,3,4,5) • MCHR (1,2) • Motilin • Opioidni (δ,κ,μ,Nociceptin &ζ, ali neσ) • Oreksin (1,2) • Oksitocin • Prokineticin (1,2) • Prolaktin-oslobađajući peptid • Relaksin (1,2,3,4) • Somatostatin (1,2,3,4,5) • Tahikinin (1,2,3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A,1B,2)

Razno

Orfan	GPR (1,3,4,6,12,15,17,18,19,20,21,22,23,25,26,27,31,32,33,34,35,37,39,42,44,45,50,52,55,61,62,63,65,68,75,77,78,81,82,83,84,85,87,88,92,101,103,109A,109B,119,120,132,135,137B,139,141,142,146,148,149,150,151,152,153,160,161,162,171,173,174,176,177,182,183)
Drugi	Adrenomedulin • Mirisni • Opsin (3,4,5,1LW,1MW,1SW,RGR,RRH) • Proteazom-aktivirani (1,2,3,4) • SREB (1,2,3)

Klasa B:Sekretinu slični

Orfan

GPR (56,64,97,98,110,111,112,113,114,115,116,123,124,125,126,128,133,143,144,155,157)

Drugi

Moždano specifični angiogenezni inhibitor (1,2,3) • Cadherin (1,2,3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1,2) • EMR (1,2,3) • Glukagon (GR,GIPR,GLP1R,GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1,2,3,ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1,2) • Sekretin • Vazoaktivni intestinalni peptid (1,2)

Klasa C:Metabotropni
glutamat /feromon

Ukus	TAS1R (1,2,3) • TAS2R (1,3,4,5,8,9,10,12,13,14,16,19,20,30,31,38,39,40,41,42,43,45,46,50)
Drugi	Kalcijum-detektujući receptor • GABA B (1,2) • Glutamatni receptor (Metabotropni glutamat (1,2,3,4,5,6,7,8)) • GPRC6A • GPR (156,158,179) • RAIG (1,2,3,4)

Klasa F:
Frizzled /Zaglađeni

Uvojiti	Frizzled (1,2,3,4,5,6,7,8,9,10)
Zaglađeni	Zaglađeni

B trdu:peptidi (nrpl/grfl/cytl/horl),receptori (lgic,enzr,gprc,igsr,intg,nrpr/grfr/cytr),itra (adap,gbpr,mapk),calc,lipd, signalni putevi (hedp,wntp,tgfp+mapp,notp,jakp,fsap,hipp,tlrp)

Izvor:https://sh.wikipedia.org/w/index.php?title=P2RY6&oldid=42509768

Kategorije:

[8]ページ先頭