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P2RY11

Uredi veze

Izvor: Wikipedija

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Purinski receptor P2Y, G-protein spregnuti, 11

Identifikatori

Simboli

P2RY11; P2Y11

Vanjski ID

OMIM: 602697IUPHAR:P2Y₁₁GeneCards:P2RY11 Gene

Ontologija gena
Molekularna funkcija	•aktivnost rodopsinu-sličnog receptora•receptorska aktivnost•aktivnost purinskog nukleotidnog receptora, G-protein spregnutog
Celularna komponenta	•integralno sa ćelijskom membranom•membrana
Biološki proces	•odbrambeni respons•prenos signala•aktivacija adenilat ciklaze•G-proteinska signalizacija, spregnuta sa IP3 sekundarnim glasnikom (aktivacija fosfolipaze C)

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

n/a

n/a

n/a

RefSeq (mRNA)

NM_002566

n/a

RefSeq (protein)

NP_002557

n/a

Lokacija (UCSC)

Chr 19:
10.08 - 10.09 Mb

n/a

PubMed pretraga

[1]

n/a

P2RY11 (P2Y purinoceptor 11) jeprotein je protein koji je kod ljudi kodiranP2RY11genom.^[1]^[2]

Protein kodiran ovim genom pripada familijiG-protein spregnutih receptora, koji su preferentno aktiviraninukleotidima adenozina iuridina. Ovaj receptor je spregnut sa stimulacijom putevafosfoinozitida iadenilil ciklaze i ponaša se kao selektivnipurinoceptor. Postoje prirodni združenitranskripti, koji nastaju intergenskimsplajsovanjem ovog gena i neposredno prethodećeg gena (PPAN, koji kodira petar pan homolog). PPAN-P2RY11iRNK je široko izražena i kodira fuzioni protein koji ima zajednički identitet individualnih genskih proizvoda.^[2]

Povezano

[uredi |uredi kod]

P2Y receptor

Reference

[uredi |uredi kod]

↑Communi D, Govaerts C, Parmentier M, Boeynaems JM (Jan 1998). „Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase”. J Biol Chem 272 (51): 31969–73. DOI:10.1074/jbc.272.51.31969. PMID 9405388.
↑^2,0^2,1„Entrez Gene: P2RY11 purinergic receptor P2Y, G-protein coupled, 11”.

Literatura

[uredi |uredi kod]

van der Weyden L, Conigrave AD, Morris MB (2000). „Signal transduction and white cell maturation via extracellular ATP and the P2Y11 receptor.”. Immunol. Cell Biol. 78 (4): 369–74. DOI:10.1046/j.1440-1711.2000.00918.x. PMID 10947861.
Adams MD, Kerlavage AR, Fleischmann RD,et al. (1995). „Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.” (PDF). Nature 377 (6547 Suppl): 3–174. PMID 7566098.
Communi D, Suarez-Huerta N, Dussossoy D,et al. (2001). „Cotranscription and intergenic splicing of human P2Y11 and SSF1 genes.”. J. Biol. Chem. 276 (19): 16561–6. DOI:10.1074/jbc.M009609200. PMID 11278528.
Moore DJ, Chambers JK, Wahlin JP,et al. (2001). „Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study.”. Biochim. Biophys. Acta 1521 (1-3): 107–19. PMID 11690642.
Duhant X, Schandené L, Bruyns C,et al. (2002). „Extracellular adenine nucleotides inhibit the activation of human CD4+ T lymphocytes.”. J. Immunol. 169 (1): 15–21. PMID 12077223.
Strausberg RL, Feingold EA, Grouse LH,et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA,et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Moreschi I, Bruzzone S, Nicholas RA,et al. (2006). „Extracellular NAD+ is an agonist of the human P2Y11 purinergic receptor in human granulocytes.”. J. Biol. Chem. 281 (42): 31419–29. DOI:10.1074/jbc.M606625200. PMID 16926152.
Zylberg J, Ecke D, Fischer B, Reiser G (2007). „Structure and ligand-binding site characteristics of the human P2Y11 nucleotide receptor deduced from computational modelling and mutational analysis.”. Biochem. J. 405 (2): 277–86. DOI:10.1042/BJ20061728. PMC 1904521. PMID 17338680.

Vanjske veze

[uredi |uredi kod]

„P2Y Receptors: P2Y₁₁”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano izoriginala na datum 2016-03-03.

Transmembranski receptor:G protein spregnuti receptori

Klasa A:Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A,B,D) • α2 (A,B,C) • β1 • β2 • β3
Purinski	Adenozinski (A1,A2A,A2B,A3) • P2Y (1,2,4,5,6,8,9,10,11,12,13,14)
Serotoninski	(svi osim 5-HT3)5-HT1 (A,B,D,E,F) • 5-HT2 (A,B,C) • 5-HT (4,5A,6,7)
Drugi	Acetilholin (M1,M2,M3,M4,M5) • Dopamin (D1,D2,D3,D4,D5) • Histamin (H1,H2,H3,H4) • Melatonin (1A,1B,1C) • TAAR (1,2,3,5,6,8,9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1,2) • LTB4 (1,2) • FPRL1 • OXE • Prostaglandin (DP (1,2),EP (1,2,3,4),FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1,CB2,GPR (18,55,119)) • EBI2 • Estrogen • Slobodna masna kiselina (1,2,3,4) • Laktat • Lizofosfatidna kiselina (1,2,3,4,5,6) • Lizofosfolipid (1,2,3,4,5,6,7,8) • Niacin (1,2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1,2,3,4,5) • Sukcinat

Peptid

Neuropeptidni

B/W (1,2) • FF (1,2) • S • Y (1,2,4,5) • Neuromedin (B,U (1,2)) • Neurotenzin (1,2)

Drugi

Anafilatoksin (C3a,C5a) • Angiotenzin (1,2) • Apelin • Bombezin (BRS3,GRPR,NMBR) • Bradikinin (B1,B2) • Hemokin • Holecistokinin (A,B) • Endotelin (A,B) • Formil peptid (1,2,3) • FSH • Galanin (1,2,3) • GHB receptor • Gonadotropin-oslobađajući hormon (1,2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1,1L,D,E,F,G,X1,X2,X3,X4) • Melanokortin (1,2,3,4,5) • MCHR (1,2) • Motilin • Opioidni (δ,κ,μ,Nociceptin &ζ, ali neσ) • Oreksin (1,2) • Oksitocin • Prokineticin (1,2) • Prolaktin-oslobađajući peptid • Relaksin (1,2,3,4) • Somatostatin (1,2,3,4,5) • Tahikinin (1,2,3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A,1B,2)

Razno

Orfan	GPR (1,3,4,6,12,15,17,18,19,20,21,22,23,25,26,27,31,32,33,34,35,37,39,42,44,45,50,52,55,61,62,63,65,68,75,77,78,81,82,83,84,85,87,88,92,101,103,109A,109B,119,120,132,135,137B,139,141,142,146,148,149,150,151,152,153,160,161,162,171,173,174,176,177,182,183)
Drugi	Adrenomedulin • Mirisni • Opsin (3,4,5,1LW,1MW,1SW,RGR,RRH) • Proteazom-aktivirani (1,2,3,4) • SREB (1,2,3)

Klasa B:Sekretinu slični

Orfan

GPR (56,64,97,98,110,111,112,113,114,115,116,123,124,125,126,128,133,143,144,155,157)

Drugi

Moždano specifični angiogenezni inhibitor (1,2,3) • Cadherin (1,2,3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1,2) • EMR (1,2,3) • Glukagon (GR,GIPR,GLP1R,GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1,2,3,ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1,2) • Sekretin • Vazoaktivni intestinalni peptid (1,2)

Klasa C:Metabotropni
glutamat /feromon

Ukus	TAS1R (1,2,3) • TAS2R (1,3,4,5,8,9,10,12,13,14,16,19,20,30,31,38,39,40,41,42,43,45,46,50)
Drugi	Kalcijum-detektujući receptor • GABA B (1,2) • Glutamatni receptor (Metabotropni glutamat (1,2,3,4,5,6,7,8)) • GPRC6A • GPR (156,158,179) • RAIG (1,2,3,4)

Klasa F:
Frizzled /Zaglađeni

Uvojiti	Frizzled (1,2,3,4,5,6,7,8,9,10)
Zaglađeni	Zaglađeni

B trdu:peptidi (nrpl/grfl/cytl/horl),receptori (lgic,enzr,gprc,igsr,intg,nrpr/grfr/cytr),itra (adap,gbpr,mapk),calc,lipd, signalni putevi (hedp,wntp,tgfp+mapp,notp,jakp,fsap,hipp,tlrp)

Izvor:https://sh.wikipedia.org/w/index.php?title=P2RY11&oldid=42508383

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