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OPN1SW

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Izvor: Wikipedija

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Opsin 1 (pigment kupe)

Identifikatori

Simboli

OPN1SW; BCP; BOP; CBT

Vanjski ID

OMIM: 190900MGI: 99438HomoloGene: 1291GeneCards:OPN1SW Gene

Ontologija gena
Molekularna funkcija	•aktivnost rodopsinu-sličnog receptora•receptorska aktivnost•aktivnost fotorecptora plave svetlosti
Celularna komponenta	•fotoreceptorski spoljašnje segment•integralno sa ćelijskom membranom•membrana
Biološki proces	•prenos signala•signalni put G-protein spregnutog receptora•vizuelna percepcija•fototransdukcija•protein-hromofor veza•respons na stimulus

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

RefSeq (mRNA)

RefSeq (protein)

Lokacija (UCSC)

Chr 7:
128.2 - 128.2 Mb

Chr 6:
29.33 - 29.33 Mb

PubMed pretraga

[1]

[2]

OPN1SW,plavo-senzitivni opsin jeprotein koji je kod ljudi kodiranOPN1SWgenom.^[1]^[2]^[3]

Povezano

[uredi |uredi kod]

Opsin

Literatura

[uredi |uredi kod]

↑Nathans J, Thomas D, Hogness DS (Apr 1986). „Molecular genetics of human color vision: the genes encoding blue, green, and red pigments”. Science 232 (4747): 193–202. DOI:10.1126/science.2937147. PMID 2937147.
↑Fitzgibbon J, Appukuttan B, Gayther S, Wells D, Delhanty J, Hunt DM (Feb 1994). „Localisation of the human blue cone pigment gene to chromosome band 7q31.3-32”. Hum Genet 93 (1): 79–80. PMID 8270261.
↑„Entrez Gene: OPN1SW opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)”.

Dodatna literatura

[uredi |uredi kod]

Applebury ML, Hargrave PA (1987). „Molecular biology of the visual pigments.”. Vision Res. 26 (12): 1881–95. DOI:10.1016/0042-6989(86)90115-X. PMID 3303660.
Swanson WH, Cohen JM (2003). „Color vision.”. Ophthalmology clinics of North America 16 (2): 179–203. DOI:10.1016/S0896-1549(03)00004-X. PMID 12809157.
Weitz CJ, Went LN, Nathans J (1992). „Human tritanopia associated with a third amino acid substitution in the blue-sensitive visual pigment.”. Am. J. Hum. Genet. 51 (2): 444–6. PMC 1682686. PMID 1386496.
Weitz CJ, Miyake Y, Shinzato K,et al. (1992). „Human tritanopia associated with two amino acid substitutions in the blue-sensitive opsin.”. Am. J. Hum. Genet. 50 (3): 498–507. PMC 1684278. PMID 1531728.
Oprian DD, Asenjo AB, Lee N, Pelletier SL (1992). „Design, chemical synthesis, and expression of genes for the three human color vision pigments.”. Biochemistry 30 (48): 11367–72. DOI:10.1021/bi00112a002. PMID 1742276.
Sarkar G, Sommer SS (1989). „Access to a messenger RNA sequence or its protein product is not limited by tissue or species specificity.”. Science 244 (4902): 331–4. DOI:10.1126/science.2565599. PMID 2565599.
Nathans J, Piantanida TP, Eddy RL,et al. (1986). „Molecular genetics of inherited variation in human color vision.”. Science 232 (4747): 203–10. DOI:10.1126/science.3485310. PMID 3485310.
Shimmin LC, Mai P, Li WH (1997). „Sequences and evolution of human and squirrel monkey blue opsin genes.”. J. Mol. Evol. 44 (4): 378–82. DOI:10.1007/PL00006157. PMID 9089077.
Scherer SW, Cheung J, MacDonald JR,et al. (2003). „Human chromosome 7: DNA sequence and biology.”. Science 300 (5620): 767–72. DOI:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Gunther KL, Neitz J, Neitz M (2006). „A novel mutation in the short-wavelength-sensitive cone pigment gene associated with a tritan color vision defect.”. Vis. Neurosci. 23 (3-4): 403–9. DOI:10.1017/S0952523806233169. PMID 16961973.

Transmembranski receptor:G protein spregnuti receptori

Klasa A:Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A,B,D) • α2 (A,B,C) • β1 • β2 • β3
Purinski	Adenozinski (A1,A2A,A2B,A3) • P2Y (1,2,4,5,6,8,9,10,11,12,13,14)
Serotoninski	(svi osim 5-HT3)5-HT1 (A,B,D,E,F) • 5-HT2 (A,B,C) • 5-HT (4,5A,6,7)
Drugi	Acetilholin (M1,M2,M3,M4,M5) • Dopamin (D1,D2,D3,D4,D5) • Histamin (H1,H2,H3,H4) • Melatonin (1A,1B,1C) • TAAR (1,2,3,5,6,8,9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1,2) • LTB4 (1,2) • FPRL1 • OXE • Prostaglandin (DP (1,2),EP (1,2,3,4),FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1,CB2,GPR (18,55,119)) • EBI2 • Estrogen • Slobodna masna kiselina (1,2,3,4) • Laktat • Lizofosfatidna kiselina (1,2,3,4,5,6) • Lizofosfolipid (1,2,3,4,5,6,7,8) • Niacin (1,2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1,2,3,4,5) • Sukcinat

Peptid

Neuropeptidni

B/W (1,2) • FF (1,2) • S • Y (1,2,4,5) • Neuromedin (B,U (1,2)) • Neurotenzin (1,2)

Drugi

Anafilatoksin (C3a,C5a) • Angiotenzin (1,2) • Apelin • Bombezin (BRS3,GRPR,NMBR) • Bradikinin (B1,B2) • Hemokin • Holecistokinin (A,B) • Endotelin (A,B) • Formil peptid (1,2,3) • FSH • Galanin (1,2,3) • GHB receptor • Gonadotropin-oslobađajući hormon (1,2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1,1L,D,E,F,G,X1,X2,X3,X4) • Melanokortin (1,2,3,4,5) • MCHR (1,2) • Motilin • Opioidni (δ,κ,μ,Nociceptin &ζ, ali neσ) • Oreksin (1,2) • Oksitocin • Prokineticin (1,2) • Prolaktin-oslobađajući peptid • Relaksin (1,2,3,4) • Somatostatin (1,2,3,4,5) • Tahikinin (1,2,3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A,1B,2)

Razno

Orfan	GPR (1,3,4,6,12,15,17,18,19,20,21,22,23,25,26,27,31,32,33,34,35,37,39,42,44,45,50,52,55,61,62,63,65,68,75,77,78,81,82,83,84,85,87,88,92,101,103,109A,109B,119,120,132,135,137B,139,141,142,146,148,149,150,151,152,153,160,161,162,171,173,174,176,177,182,183)
Drugi	Adrenomedulin • Mirisni • Opsin (3,4,5,1LW,1MW,1SW,RGR,RRH) • Proteazom-aktivirani (1,2,3,4) • SREB (1,2,3)

Klasa B:Sekretinu slični

Orfan

GPR (56,64,97,98,110,111,112,113,114,115,116,123,124,125,126,128,133,143,144,155,157)

Drugi

Moždano specifični angiogenezni inhibitor (1,2,3) • Cadherin (1,2,3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1,2) • EMR (1,2,3) • Glukagon (GR,GIPR,GLP1R,GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1,2,3,ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1,2) • Sekretin • Vazoaktivni intestinalni peptid (1,2)

Klasa C:Metabotropni
glutamat /feromon

Ukus	TAS1R (1,2,3) • TAS2R (1,3,4,5,8,9,10,12,13,14,16,19,20,30,31,38,39,40,41,42,43,45,46,50)
Drugi	Kalcijum-detektujući receptor • GABA B (1,2) • Glutamatni receptor (Metabotropni glutamat (1,2,3,4,5,6,7,8)) • GPRC6A • GPR (156,158,179) • RAIG (1,2,3,4)

Klasa F:
Frizzled /Zaglađeni

Uvojiti	Frizzled (1,2,3,4,5,6,7,8,9,10)
Zaglađeni	Zaglađeni

B trdu:peptidi (nrpl/grfl/cytl/horl),receptori (lgic,enzr,gprc,igsr,intg,nrpr/grfr/cytr),itra (adap,gbpr,mapk),calc,lipd, signalni putevi (hedp,wntp,tgfp+mapp,notp,jakp,fsap,hipp,tlrp)

Izvor:https://sh.wikipedia.org/w/index.php?title=OPN1SW&oldid=42508617

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