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OPN1MW

Uredi veze

Izvor: Wikipedija

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Opsin 1, senzitivan na srednje talasne dužine

Identifikatori

Simboli

OPN1MW; CBBM; CBD; GCP

Vanjski ID

OMIM: 303800HomoloGene: 88332GeneCards:OPN1MW Gene

Ontologija gena
Molekularna funkcija	•aktivnost rodopsinu-sličnog receptora•fotoreceptorska aktivnost
Celularna komponenta	•integralno sa ćelijskom membranom•membrana
Biološki proces	•prenos signala•signalni put G-protein spregnutog receptora•vizuelna percepcija•fototransdukcija•protein-hromofor veza•respons na stimulus

Ortolozi

Vrsta

Čovek

Miš

n/a

n/a

n/a

RefSeq (mRNA)

NM_000513

n/a

RefSeq (protein)

NP_000504

n/a

Lokacija (UCSC)

n/a

PubMed pretraga

[1]

n/a

OPN1MW,zeleno-senzitivni opsin, jeprotein koji je kod ljudi kodiranOPN1MWgenom.^[1]

Povezano

[uredi |uredi kod]

Opsin

Literatura

[uredi |uredi kod]

↑„Entrez Gene: OPN1MW opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan)”. PMID 2652.

Dodatna literatura

[uredi |uredi kod]

Applebury ML, Hargrave PA (1987). „Molecular biology of the visual pigments.”. Vision Res. 26 (12): 1881–95. DOI:10.1016/0042-6989(86)90115-X. PMID 3303660.
Winderickx J, Sanocki E, Lindsey DT,et al. (1993). „Defective colour vision associated with a missense mutation in the human green visual pigment gene.”. Nat. Genet. 1 (4): 251–6. DOI:10.1038/ng0792-251. PMID 1302020.
Neitz J, Neitz M, Jacobs GH (1990). „Analysis of fusion gene and encoded photopigment of colour-blind humans.”. Nature 342 (6250): 679–82. DOI:10.1038/342679a0. PMID 2574415.
Nathans J, Thomas D, Hogness DS (1986). „Molecular genetics of human color vision: the genes encoding blue, green, and red pigments.”. Science 232 (4747): 193–202. DOI:10.1126/science.2937147. PMID 2937147.
Li ZY, Kljavin IJ, Milam AH (1995). „Rod photoreceptor neurite sprouting in retinitis pigmentosa.”. J. Neurosci. 15 (8): 5429–38. PMID 7643192.
Ladekjaer-Mikkelsen AS, Rosenberg T, Jørgensen AL (1996). „A new mechanism in blue cone monochromatism.”. Hum. Genet. 98 (4): 403–8. DOI:10.1007/s004390050229. PMID 8792812.
Ferreira PA, Nakayama TA, Pak WL, Travis GH (1996). „Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin.”. Nature 383 (6601): 637–40. DOI:10.1038/383637a0. PMID 8857542.
Vissers PM, Bovee-Geurts PH, Portier MD,et al. (1998). „Large-scale production and purification of the human green cone pigment: characterization of late photo-intermediates.”. Biochem. J.. 330 (Pt 3): 1201–8. PMC 1219262. PMID 9494086.
Bernstein SL, Wong P (1998). „Regional expression of disease-related genes in human and monkey retina.”. Mol. Vis. 4: 24. PMID 9815288.
Hayashi T, Motulsky AG, Deeb SS (1999). „Position of a 'green-red' hybrid gene in the visual pigment array determines colour-vision phenotype.”. Nat. Genet. 22 (1): 90–3. DOI:10.1038/8798. PMID 10319869.
Ueyama H, Kuwayama S, Imai H,et al. (2002). „Novel missense mutations in red/green opsin genes in congenital color-vision deficiencies.”. Biochem. Biophys. Res. Commun. 294 (2): 205–9. DOI:10.1016/S0006-291X(02)00458-8. PMID 12051694.
Zhu X, Brown B, Li A,et al. (2003). „GRK1-dependent phosphorylation of S and M opsins and their binding to cone arrestin during cone phototransduction in the mouse retina.”. J. Neurosci. 23 (14): 6152–60. PMID 12853434.
Bonilha VL, Hollyfield JG, Grover S, Fishman GA (2005). „Abnormal distribution of red/green cone opsins in a patient with an autosomal dominant cone dystrophy.”. Ophthalmic Genet. 26 (2): 69–76. DOI:10.1080/13816810590968041. PMID 16020309.

Vanjske veze

[uredi |uredi kod]

Crveno-zeleni defekti vida

Transmembranski receptor:G protein spregnuti receptori

Klasa A:Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A,B,D) • α2 (A,B,C) • β1 • β2 • β3
Purinski	Adenozinski (A1,A2A,A2B,A3) • P2Y (1,2,4,5,6,8,9,10,11,12,13,14)
Serotoninski	(svi osim 5-HT3)5-HT1 (A,B,D,E,F) • 5-HT2 (A,B,C) • 5-HT (4,5A,6,7)
Drugi	Acetilholin (M1,M2,M3,M4,M5) • Dopamin (D1,D2,D3,D4,D5) • Histamin (H1,H2,H3,H4) • Melatonin (1A,1B,1C) • TAAR (1,2,3,5,6,8,9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1,2) • LTB4 (1,2) • FPRL1 • OXE • Prostaglandin (DP (1,2),EP (1,2,3,4),FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1,CB2,GPR (18,55,119)) • EBI2 • Estrogen • Slobodna masna kiselina (1,2,3,4) • Laktat • Lizofosfatidna kiselina (1,2,3,4,5,6) • Lizofosfolipid (1,2,3,4,5,6,7,8) • Niacin (1,2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1,2,3,4,5) • Sukcinat

Peptid

Neuropeptidni

B/W (1,2) • FF (1,2) • S • Y (1,2,4,5) • Neuromedin (B,U (1,2)) • Neurotenzin (1,2)

Drugi

Anafilatoksin (C3a,C5a) • Angiotenzin (1,2) • Apelin • Bombezin (BRS3,GRPR,NMBR) • Bradikinin (B1,B2) • Hemokin • Holecistokinin (A,B) • Endotelin (A,B) • Formil peptid (1,2,3) • FSH • Galanin (1,2,3) • GHB receptor • Gonadotropin-oslobađajući hormon (1,2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1,1L,D,E,F,G,X1,X2,X3,X4) • Melanokortin (1,2,3,4,5) • MCHR (1,2) • Motilin • Opioidni (δ,κ,μ,Nociceptin &ζ, ali neσ) • Oreksin (1,2) • Oksitocin • Prokineticin (1,2) • Prolaktin-oslobađajući peptid • Relaksin (1,2,3,4) • Somatostatin (1,2,3,4,5) • Tahikinin (1,2,3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A,1B,2)

Razno

Orfan	GPR (1,3,4,6,12,15,17,18,19,20,21,22,23,25,26,27,31,32,33,34,35,37,39,42,44,45,50,52,55,61,62,63,65,68,75,77,78,81,82,83,84,85,87,88,92,101,103,109A,109B,119,120,132,135,137B,139,141,142,146,148,149,150,151,152,153,160,161,162,171,173,174,176,177,182,183)
Drugi	Adrenomedulin • Mirisni • Opsin (3,4,5,1LW,1MW,1SW,RGR,RRH) • Proteazom-aktivirani (1,2,3,4) • SREB (1,2,3)

Klasa B:Sekretinu slični

Orfan

GPR (56,64,97,98,110,111,112,113,114,115,116,123,124,125,126,128,133,143,144,155,157)

Drugi

Moždano specifični angiogenezni inhibitor (1,2,3) • Cadherin (1,2,3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1,2) • EMR (1,2,3) • Glukagon (GR,GIPR,GLP1R,GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1,2,3,ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1,2) • Sekretin • Vazoaktivni intestinalni peptid (1,2)

Klasa C:Metabotropni
glutamat /feromon

Ukus	TAS1R (1,2,3) • TAS2R (1,3,4,5,8,9,10,12,13,14,16,19,20,30,31,38,39,40,41,42,43,45,46,50)
Drugi	Kalcijum-detektujući receptor • GABA B (1,2) • Glutamatni receptor (Metabotropni glutamat (1,2,3,4,5,6,7,8)) • GPRC6A • GPR (156,158,179) • RAIG (1,2,3,4)

Klasa F:
Frizzled /Zaglađeni

Uvojiti	Frizzled (1,2,3,4,5,6,7,8,9,10)
Zaglađeni	Zaglađeni

B trdu:peptidi (nrpl/grfl/cytl/horl),receptori (lgic,enzr,gprc,igsr,intg,nrpr/grfr/cytr),itra (adap,gbpr,mapk),calc,lipd, signalni putevi (hedp,wntp,tgfp+mapp,notp,jakp,fsap,hipp,tlrp)

Izvor:https://sh.wikipedia.org/w/index.php?title=OPN1MW&oldid=42506422

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