Movatterモバイル変換

[0]ホーム
URL:

Prijeđi na sadržaj
Wikipedija
Pretraga

Niklosamid

Izvor: Wikipedija
Niklosamid
Klinički podaci
AHFS/Drugs.comMonografija
Identifikatori
CAS broj50-65-7
ATC kodP02DA01
PubChem[1][2]4477
DrugBankDB06803
ChemSpider[3]4322
ChEMBL[4]CHEMBL1448 DaY
Hemijski podaci
FormulaC13H8Cl2N2O4 
Mol. masa327,120
SMILESeMolekuli &PubHem
InChI
InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
Key: RJMUSRYZPJIFPJ-UHFFFAOYSA-N DaY
Fizički podaci
Tačka topljenja230 °C (446 °F)
Farmakoinformacioni podaci
Trudnoća?
Pravni status
Način primeneOralno

Niklosamid jeorgansko jedinjenje, koje sadrži 13atomaugljenika i imamolekulsku masu od 327,120Da.[5][6][7][8]

Osobine

[uredi |uredi kod]
OsobinaVrednost
Broj akceptora vodonika4
Broj donora vodonika2
Broj rotacionih veza3
Particioni koeficijent[9] (ALogP)3,6
Rastvorljivost[10] (logS, log(mol/L))-5,1
Polarna površina[11] (PSA,Å2)95,2

Reference

[uredi |uredi kod]
  1. ↑Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ↑Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ↑Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. ↑Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  5. ↑Rosenthal Philip J, Chapter 53. Clinical Pharmacology of the Antihelminthic Drugs (Chapter). Katzung BG: Basic & Clinical Pharmacology, 11e:http://www.accessmedicine.com/content.aspx?aID=4516635:http://www.accessmedicine.com/content.aspx?aID=4516635.
  6. ↑2010. Detailed Drug Information for the Consumer. Greenwood Village, CO. Thomson Reuters.ISBN1-56363-575-5. ISSN: 0740-4174. STAT!Ref Online Electronic Medical Library.
  7. ↑Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. DOI:10.1093/nar/gkq1126. PMC 3013709. PMID 21059682.  edit
  8. ↑David S. Wishart, Craig Knox, An Chi Guo, Dean Cheng, Savita Shrivastava, Dan Tzur, Bijaya Gautam, and Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. DOI:10.1093/nar/gkm958. PMC 2238889. PMID 18048412.  edit
  9. ↑Ghose, A.K., Viswanadhan V.N., and Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A 102: 3762-3772. DOI:10.1021/jp980230o. 
  10. ↑Tetko IV, Tanchuk VY, Kasheva TN, Villa AE. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488-1493. DOI:10.1021/ci000392t. PMID 11749573.  edit
  11. ↑Ertl P., Rohde B., Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714-3717. DOI:10.1021/jm000942e. PMID 11020286.  edit

Literatura

[uredi |uredi kod]

Vanjske veze

[uredi |uredi kod]
Portal Medicina
Portal Hemija
Niklosamid naWikimedijinoj ostavi
Izvor:https://sh.wikipedia.org/w/index.php?title=Niklosamid&oldid=42299437
Kategorije:
[8]ページ先頭
©2009-2025 Movatter.jp