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Neuropeptidni B/W receptor 2

Uredi veze

Izvor: Wikipedija

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Neuropeptidni B/W receptor 2

Identifikatori

Simboli

NPBWR2; GPR8

Vanjski ID

OMIM: 600731HomoloGene: 48336IUPHAR:NPBW2GeneCards:NPBWR2 Gene

Ontologija gena
Molekularna funkcija	•aktivnost rodopsinu-sličnog receptora•receptorska aktivnost•aktivnost opioidnog receptora•proteinsko vezivanje
Celularna komponenta	•membrana•integralno sa membranom
Biološki proces	•prenost signala•signalni put G-protein spregnutog receptora•neuropeptidni signalni put•sinaptička transmisija

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

n/a

n/a

n/a

RefSeq (mRNA)

NM_005286

n/a

RefSeq (protein)

NP_005277

n/a

Lokacija (UCSC)

Chr 20:
62.21 - 62.21 Mb

n/a

PubMed pretraga

[1]

n/a

Neuropeptidni B/W receptor 2 (NPBW2) je humaniprotein kodiranNPBWR2genom.^[1]

Ovaj protein jeintegralni membranski protein iG protein-spregnuti receptor. Njegova sekvenca je sličnaGPR7 receptoru. On je strukturno sličanopioidnim isomatostatinskim receptorima. Ovaj protein vezujeneuropeptide B i W. Ovaj gen ne sadrži introne. Prvenstveno je izražen u frontalnom korteksu mozga.^[1]

Povezano

[uredi |uredi kod]

Neuropeptidni B/W receptor

Literatura

[uredi |uredi kod]

↑^1,0^1,1„Entrez Gene: NPBWR2 neuropeptides B/W receptor 2”.

Dodatna literatura

[uredi |uredi kod]

O'Dowd BF, Scheideler MA, Nguyen T,et al. (1995). „The cloning and chromosomal mapping of two novel human opioid-somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain.”. Genomics 28 (1): 84–91. DOI:10.1006/geno.1995.1109. PMID 7590751.
Deloukas P, Matthews LH, Ashurst J,et al. (2002). „The DNA sequence and comparative analysis of human chromosome 20.”. Nature 414 (6866): 865–71. DOI:10.1038/414865a. PMID 11780052.
Shimomura Y, Harada M, Goto M,et al. (2002). „Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8.”. J. Biol. Chem. 277 (39): 35826–32. DOI:10.1074/jbc.M205337200. PMID 12130646.
Brezillon S, Lannoy V, Franssen JD,et al. (2003). „Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8.”. J. Biol. Chem. 278 (2): 776–83. DOI:10.1074/jbc.M206396200. PMID 12401809.
Strausberg RL, Feingold EA, Grouse LH,et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Tanaka H, Yoshida T, Miyamoto N,et al. (2003). „Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8.”. Proc. Natl. Acad. Sci. U.S.A. 100 (10): 6251–6. DOI:10.1073/pnas.0837789100. PMC 156358. PMID 12719537.
Mazzocchi G, Rebuffat P, Ziolkowska A,et al. (2005). „G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades.”. J. Clin. Endocrinol. Metab. 90 (6): 3466–71. DOI:10.1210/jc.2004-2132. PMID 15797961.

Vanjske veze

[uredi |uredi kod]

„Neuropeptide B/W Receptors: NPBW2”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano izoriginala na datum 2016-03-03.

Transmembranski receptor:G protein spregnuti receptori

Klasa A:Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A,B,D) • α2 (A,B,C) • β1 • β2 • β3
Purinski	Adenozinski (A1,A2A,A2B,A3) • P2Y (1,2,4,5,6,8,9,10,11,12,13,14)
Serotoninski	(svi osim 5-HT3)5-HT1 (A,B,D,E,F) • 5-HT2 (A,B,C) • 5-HT (4,5A,6,7)
Drugi	Acetilholin (M1,M2,M3,M4,M5) • Dopamin (D1,D2,D3,D4,D5) • Histamin (H1,H2,H3,H4) • Melatonin (1A,1B,1C) • TAAR (1,2,3,5,6,8,9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1,2) • LTB4 (1,2) • FPRL1 • OXE • Prostaglandin (DP (1,2),EP (1,2,3,4),FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1,CB2,GPR (18,55,119)) • EBI2 • Estrogen • Slobodna masna kiselina (1,2,3,4) • Laktat • Lizofosfatidna kiselina (1,2,3,4,5,6) • Lizofosfolipid (1,2,3,4,5,6,7,8) • Niacin (1,2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1,2,3,4,5) • Sukcinat

Peptid

Neuropeptidni

B/W (1,2) • FF (1,2) • S • Y (1,2,4,5) • Neuromedin (B,U (1,2)) • Neurotenzin (1,2)

Drugi

Anafilatoksin (C3a,C5a) • Angiotenzin (1,2) • Apelin • Bombezin (BRS3,GRPR,NMBR) • Bradikinin (B1,B2) • Hemokin • Holecistokinin (A,B) • Endotelin (A,B) • Formil peptid (1,2,3) • FSH • Galanin (1,2,3) • GHB receptor • Gonadotropin-oslobađajući hormon (1,2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1,1L,D,E,F,G,X1,X2,X3,X4) • Melanokortin (1,2,3,4,5) • MCHR (1,2) • Motilin • Opioidni (δ,κ,μ,Nociceptin &ζ, ali neσ) • Oreksin (1,2) • Oksitocin • Prokineticin (1,2) • Prolaktin-oslobađajući peptid • Relaksin (1,2,3,4) • Somatostatin (1,2,3,4,5) • Tahikinin (1,2,3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A,1B,2)

Razno

Orfan	GPR (1,3,4,6,12,15,17,18,19,20,21,22,23,25,26,27,31,32,33,34,35,37,39,42,44,45,50,52,55,61,62,63,65,68,75,77,78,81,82,83,84,85,87,88,92,101,103,109A,109B,119,120,132,135,137B,139,141,142,146,148,149,150,151,152,153,160,161,162,171,173,174,176,177,182,183)
Drugi	Adrenomedulin • Mirisni • Opsin (3,4,5,1LW,1MW,1SW,RGR,RRH) • Proteazom-aktivirani (1,2,3,4) • SREB (1,2,3)

Klasa B:Sekretinu slični

Orfan

GPR (56,64,97,98,110,111,112,113,114,115,116,123,124,125,126,128,133,143,144,155,157)

Drugi

Moždano specifični angiogenezni inhibitor (1,2,3) • Cadherin (1,2,3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1,2) • EMR (1,2,3) • Glukagon (GR,GIPR,GLP1R,GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1,2,3,ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1,2) • Sekretin • Vazoaktivni intestinalni peptid (1,2)

Klasa C:Metabotropni
glutamat /feromon

Ukus	TAS1R (1,2,3) • TAS2R (1,3,4,5,8,9,10,12,13,14,16,19,20,30,31,38,39,40,41,42,43,45,46,50)
Drugi	Kalcijum-detektujući receptor • GABA B (1,2) • Glutamatni receptor (Metabotropni glutamat (1,2,3,4,5,6,7,8)) • GPRC6A • GPR (156,158,179) • RAIG (1,2,3,4)

Klasa F:
Frizzled /Zaglađeni

Uvojiti	Frizzled (1,2,3,4,5,6,7,8,9,10)
Zaglađeni	Zaglađeni

B trdu:peptidi (nrpl/grfl/cytl/horl),receptori (lgic,enzr,gprc,igsr,intg,nrpr/grfr/cytr),itra (adap,gbpr,mapk),calc,lipd, signalni putevi (hedp,wntp,tgfp+mapp,notp,jakp,fsap,hipp,tlrp)

Neuropeptidni receptori

Hormonski receptori

Hipotalamusni	CRH -FSH -LHRH -TRH -Somatostatin
Hipofizni	Vazopresin (1A,1B,2) -Oksitocin -LHCG -Tip I citokinski receptor (GH,Prolaktin) -TSH
Drugi	Atrijalni natriuretski faktor (NPR1,NPR2,NPR3) -Kalcitonin -Holecistokinin (A,B) -VIP

Opioidni receptori

Delta -Kapa -Mi -Sigma (1,2) -Nociceptin

Drugi neuropeptidni receptori

Angiotenzin -Bradikinin (B1,B2) /Tahikinin (TACR1) -Kalcitoninu sličan -Galanin -GPCR neuropeptid (B/W,FF,S,Y) -Neurotenzin

B trdu:peptidi (nrpl/grfl/cytl/horl),receptori (lgic,enzr,gprc,igsr,intg,nrpr/grfr/cytr),itra (adap,gbpr,mapk),calc,lipd, signalni putevi (hedp,wntp,tgfp+mapp,notp,jakp,fsap,hipp,tlrp)

Izvor:https://sh.wikipedia.org/w/index.php?title=Neuropeptidni_B/W_receptor_2&oldid=42508657

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