Funkcije

Ligandi

• acetilholin
• karbahol
• oksotremorin

• LY-2033298^[9]
• VU-0152100
• VU-0152099^[10]

• AFDX-384 (mešoviti M2/M4 antagonist, N-[2-[2-[(dipropilamino)metil]-1-piperidinil]etil]-5,6-dihidro-6-okso-11H-pirido[2,3-b][1,4]benzodiazepin-11-karboksamid
• Dicikloverin^[11]
• Himbacin
• Mamba toksin 3^[12]
• PD-102,807 etil estar (3,6a,11,14-tetrahidro-9-metoksi-2-metil-(12H)-izohino[1,2-b]pirolo[3,2-f][1,3]benzoksazin-1-karboksilne kiseline
• PD-0298029
• Tropikamid - umereno selektivan u odnosu na druge muskarinske podtipove (oko 2-5 puta)^[13]

Reference

1. ↑^1,01,1„Entrez Gene: CHRM4 cholinergic receptor, muscarinic 4”. 
2. ↑Grewal RP, Martinez M, Hoehe M, Bonner TI, Gershon ES, Detera-Wadleigh S (May 1992). „Genetic linkage mapping of the m4 human muscarinic receptor (CHRM4)”. Genomics 13 (1): 239–40. DOI:10.1016/0888-7543(92)90236-L. PMID 1577490. 
3. ↑Gomeza J, Zhang L, Kostenis E, Felder C, Bymaster F, Brodkin J, Shannon H, Xia B, Deng C, Wess J (August 1999). „Enhancement of D1 dopamine receptor-mediated locomotor stimulation in M(4) muscarinic acetylcholine receptor knockout mice”. Proceedings of the National Academy of Sciences of the United States of America 96 (18): 10483–8. PMC 17915. PMID 10468635. 
4. ↑Jeon J, Dencker D, Wörtwein G,et al. (February 2010). „A subpopulation of neuronal M4 muscarinic acetylcholine receptors plays a critical role in modulating dopamine-dependent behaviors”. J. Neurosci. 30 (6): 2396–405. DOI:10.1523/JNEUROSCI.3843-09.2010. PMC 2824442. PMID 20147565. 
5. ↑Schmidt L. S., Thomsen M., Weikop P., Dencker D., Wess J. R., Woldbye D. P. D., Wortwein G., Fink-Jensen A. (2011). „Increased cocaine self-administration in M4 muscarinic acetylcholine receptor knockout mice”. Psychopharmacology 216 (3): 367–378. DOI:10.1007/s00213-011-2225-4. PMID 21373792. 
6. ↑Langmead CJ, Watson J, Reavill C (February 2008). „Muscarinic acetylcholine receptors as CNS drug targets”. Pharmacology & Therapeutics 117 (2): 232–43. DOI:10.1016/j.pharmthera.2007.09.009. PMID 18082893. 
7. ↑Stein IS, Hell JW (June 2010). „CaMKII hunkers down on the muscarinic M4 receptor to help curb cocaine-induced hyperlocomotion”. The EMBO Journal 29 (12): 1943–5. DOI:10.1038/emboj.2010.105. PMC 2892364. PMID 20551968. 
8. ↑Guo ML, Mao LM, Wang JQ (December 2010). „Modulation of M4 muscarinic acetylcholine receptors by interacting proteins”. Neuroscience Bulletin 26 (6): 469–73. PMC 3139403. PMID 21113197. 
9. ↑Chan WY, McKinzie DL, Bose S,et al. (2008). „Allosteric modulation of the muscarinic M4 receptor as an approach to treating schizophrenia”. PNAS 105 (31): 10978–83. DOI:10.1073/pnas.0800567105. PMC 2495016. PMID 18678919. 
10. ↑Brady AE, Jones CK, Bridges TM,et al. (2008). „Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats”. J. Pharmacol. Exp. Ther. 327 (3): 941–53. DOI:10.1124/jpet.108.140350. PMC 2745822. PMID 18772318. 
11. ↑Teaktong T, Piggott MA, Mckeith IG, Perry RH, Ballard CG, Perry EK (June 2005). „Muscarinic M2 and M4 receptors in anterior cingulate cortex: relation to neuropsychiatric symptoms in dementia with Lewy bodies”. Behavioural Brain Research 161 (2): 299–305. DOI:10.1016/j.bbr.2005.02.019. PMID 15922057. 
12. ↑Muscarinic toxin 3, Dendroaspis angusticeps (Eastern green mamba)
13. ↑Lazareno S, Buckley NJ, Roberts FF (December 1990). „Characterization of muscarinic M4 binding sites in rabbit lung, chicken heart, and NG108-15 cells”. Molecular Pharmacology 38 (6): 805–15. PMID 2250662. 

Literatura

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