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Imidapril

Izvor: Wikipedija

Imidapril

(IUPAC) ime

(4S)-3-[(2S)-2- {[(2S)-1-etoksi-1-okso-4-fenilbutan-2-il]amino}propanoil]-1-metil-2-oksoimidazolidin-4-karboksilna kiselina

Klinički podaci

AHFS/Drugs.com

Identifikatori

CAS broj

PubChem^[1]^[2]

Hemijski podaci

C₂₀H₂₇N₃O₆

405,444 g/mol

InChI
InChI=1S/C20H27N3O6/c1-4-29-19(27)15(11-10-14-8-6-5-7-9-14)21-13(2)17(24)23-16(18(25)26)12-22(3)20(23)28/h5-9,13,15-16,21H,4,10-12H2,1-3H3,(H,25,26)/t13-,15-,16-/m0/s1^Y Key: KLZWOWYOHUKJIG-BPUTZDHNSA-N^Y

Farmakoinformacioni podaci

Trudnoća

Imidapril jeACE inhibitor koji se koristi kaoantihipertenzivni lek za tretmanhroničnog zatajenja srca.^[6]

↑Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑Robinson, D. M.; Curran, M. P.; Lyseng-Williamson, K. A. (2007). „Imidapril: A review of its use in essential hypertension, Type 1 diabetic nephropathy and chronic heart failure”. Drugs 67 (9): 1359–1378. PMID 17547476.