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Hormon rasta oslobađajući hormonski receptor

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Izvor: Wikipedija

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Hormon rasta oslobađajući hormonski receptor‎

Dostupne strukture

2XDG

Identifikatori

Simboli

GHRHR; GHRFR; GRFR; IGHD1B

Vanjski ID

OMIM: 139191MGI: 95710HomoloGene: 640IUPHAR:GHRHGeneCards:GHRHR Gene

Ontologija gena
Molekularna funkcija	•aktivnost G protein spregnutog receptora•proteinsko vezivanje•aktivnost hormon rasta oslobađajućeg hormonskog receptor‎a
Celularna komponenta	•integralno sa ćelijskom membranom•integralno sa membranom
Biološki proces	•signalni put G protein spregnutog receptora•neuropeptidni signalni put•međućelijska signalizacija

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

RefSeq (mRNA)

RefSeq (protein)

Lokacija (UCSC)

Chr 7:
30.98 - 31.03 Mb

Chr 6:
55.33 - 55.34 Mb

PubMed pretraga

[1]

[2]

Hormon rasta oslobađajući hormonski receptor (GHRHR) jeG protein spregnuti receptor za koji se vezujehormon faktora rasta. GHRHR aktivira Gs protein što iniciracAMP kaskadu putemadenilat ciklaze.^[1]

Ovaj gen, je izražen u hipofizi. Vezivanje hormona za receptor dovodi do sinteze i otpuštanjahormona rasta. Mutacije ovog gena su asocirane sa deficijencijama hormona rasta, poremećajima koji su karakterisani niskim rastom. Višealternativnih transkripcionih splajsnih varijanti, koje kodiraju različite izoforme je poznato, ali su samo dve bile karakterisane do sada.^[2]

Ligand

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Antagonisti

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MZ-5-156^[3]^[4]

Reference

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↑Gaylinn BD (2002). „Growth hormone releasing hormone receptor”. Recept. Channels 8 (3–4): 155–62. DOI:10.1080/10606820213679. PMID 12529933.
↑„Entrez Gene: GHRHR growth hormone releasing hormone receptor”.
↑Kovács M, Schally AV, Zarándi M, Groot K (1997). „Inhibition of GH release of rats by new potent antagonists of growth hormone-releasing hormone (GH-RH)”. Peptides 18 (3): 431–8. DOI:10.1016/S0196-9781(96)00334-8. PMID 9145432.
↑Banks WA, Morley JE, Farr SA, Price TO, Ercal N, Vidaurre I, Schally AV (December 2010). „Effects of a growth hormone-releasing hormone antagonist on telomerase activity, oxidative stress, longevity, and aging in mice”. Proceedings of the National Academy of Sciences of the United States of America 107 (51): 22272–7. DOI:10.1073/pnas.1016369107. PMID 21135231.

Literatura

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Gaylinn BD (1999). „Molecular and cell biology of the growth hormone-releasing hormone receptor.”. Growth Horm. IGF Res. 9 Suppl A: 37–44. DOI:10.1016/S1096-6374(99)80008-2. PMID 10429879.
Lin-Su K, Wajnrajch MP (2003). „Growth Hormone Releasing Hormone (GHRH) and the GHRH Receptor.”. Reviews in endocrine & metabolic disorders 3 (4): 313–23. DOI:10.1023/A:1020949507265. PMID 12424433.
Mayo KE (1992). „Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone.”. Mol. Endocrinol. 6 (10): 1734–44. DOI:10.1210/me.6.10.1734. PMID 1333056.
Squire J, Zhou A, Hassel BA,et al. (1994). „Localization of the interferon-induced, 2-5A-dependent RNase gene (RNS4) to human chromosome 1q25.”. Genomics 19 (1): 174–5. DOI:10.1006/geno.1994.1033. PMID 7514564.
Hashimoto K, Koga M, Motomura T,et al. (1995). „Identification of alternatively spliced messenger ribonucleic acid encoding truncated growth hormone-releasing hormone receptor in human pituitary adenomas.”. J. Clin. Endocrinol. Metab. 80 (10): 2933–9. DOI:10.1210/jc.80.10.2933. PMID 7559877.
Tang J, Lagacé G, Castagné J, Collu R (1995). „Identification of human growth hormone-releasing hormone receptor splicing variants.”. J. Clin. Endocrinol. Metab. 80 (8): 2381–7. DOI:10.1210/jc.80.8.2381. PMID 7629234.
Gaylinn BD, Harrison JK, Zysk JR,et al. (1993). „Molecular cloning and expression of a human anterior pituitary receptor for growth hormone-releasing hormone.”. Mol. Endocrinol. 7 (1): 77–84. DOI:10.1210/me.7.1.77. PMID 7680413.
Gaylinn BD, von Kap-Herr C, Golden WL, Thorner MO (1994). „Assignment of the human growth hormone-releasing hormone receptor gene (GHRHR) to 7p14 by in situ hybridization.”. Genomics 19 (1): 193–5. DOI:10.1006/geno.1994.1045. PMID 8188233.
Wajnrajch MP, Gertner JM, Harbison MD,et al. (1996). „Nonsense mutation in the human growth hormone-releasing hormone receptor causes growth failure analogous to the little (lit) mouse.”. Nat. Genet. 12 (1): 88–90. DOI:10.1038/ng0196-88. PMID 8528260.
Netchine I, Talon P, Dastot F,et al. (1998). „Extensive phenotypic analysis of a family with growth hormone (GH) deficiency caused by a mutation in the GH-releasing hormone receptor gene.”. J. Clin. Endocrinol. Metab. 83 (2): 432–6. DOI:10.1210/jc.83.2.432. PMID 9467553.
Petersenn S, Rasch AC, Heyens M, Schulte HM (1998). „Structure and regulation of the human growth hormone-releasing hormone receptor gene.”. Mol. Endocrinol. 12 (2): 233–47. DOI:10.1210/me.12.2.233. PMID 9482665.
Maheshwari HG, Silverman BL, Dupuis J, Baumann G (1998). „Phenotype and genetic analysis of a syndrome caused by an inactivating mutation in the growth hormone-releasing hormone receptor: Dwarfism of Sindh.”. J. Clin. Endocrinol. Metab. 83 (11): 4065–74. DOI:10.1210/jc.83.11.4065. PMID 9814493.
Salvatori R, Hayashida CY, Aguiar-Oliveira MH,et al. (1999). „Familial dwarfism due to a novel mutation of the growth hormone-releasing hormone receptor gene.”. J. Clin. Endocrinol. Metab. 84 (3): 917–23. DOI:10.1210/jc.84.3.917. PMID 10084571.
Morel G, Gallego R, Boulanger L,et al. (2000). „Restricted presence of the growth hormone-releasing hormone receptor to somatotropes in rat and human pituitaries.”. Neuroendocrinology 70 (2): 128–36. DOI:10.1159/000054467. PMID 10461027.
Rekasi Z, Czompoly T, Schally AV, Halmos G (2000). „Isolation and sequencing of cDNAs for splice variants of growth hormone-releasing hormone receptors from human cancers.”. Proc. Natl. Acad. Sci. U.S.A. 97 (19): 10561–6. DOI:10.1073/pnas.180313297. PMC 27064. PMID 10962031.
Salvatori R, Fan X, Phillips JA,et al. (2001). „Three new mutations in the gene for the growth hormone (gh)-releasing hormone receptor in familial isolated gh deficiency type ib.”. J. Clin. Endocrinol. Metab. 86 (1): 273–9. DOI:10.1210/jc.86.1.273. PMID 11232012.
Kiaris H, Schally AV, Busto R,et al. (2002). „Expression of a splice variant of the receptor for GHRH in 3T3 fibroblasts activates cell proliferation responses to GHRH analogs.”. Proc. Natl. Acad. Sci. U.S.A. 99 (1): 196–200. DOI:10.1073/pnas.012590999. PMC 117538. PMID 11773624.
Salvatori R, Fan X, Mullis PE,et al. (2002). „Decreased expression of the GHRH receptor gene due to a mutation in a Pit-1 binding site.”. Mol. Endocrinol. 16 (3): 450–8. DOI:10.1210/me.16.3.450. PMID 11875102.
Plonowski A, Schally AV, Busto R,et al. (2003). „Expression of growth hormone-releasing hormone (GHRH) and splice variants of GHRH receptors in human experimental prostate cancers.”. Peptides 23 (6): 1127–33. DOI:10.1016/S0196-9781(02)00043-8. PMID 12126741.

Vanjske veze

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Transmembranski receptor:G protein spregnuti receptori

Klasa A:Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A,B,D) • α2 (A,B,C) • β1 • β2 • β3
Purinski	Adenozinski (A1,A2A,A2B,A3) • P2Y (1,2,4,5,6,8,9,10,11,12,13,14)
Serotoninski	(svi osim 5-HT3)5-HT1 (A,B,D,E,F) • 5-HT2 (A,B,C) • 5-HT (4,5A,6,7)
Drugi	Acetilholin (M1,M2,M3,M4,M5) • Dopamin (D1,D2,D3,D4,D5) • Histamin (H1,H2,H3,H4) • Melatonin (1A,1B,1C) • TAAR (1,2,3,5,6,8,9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1,2) • LTB4 (1,2) • FPRL1 • OXE • Prostaglandin (DP (1,2),EP (1,2,3,4),FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1,CB2,GPR (18,55,119)) • EBI2 • Estrogen • Slobodna masna kiselina (1,2,3,4) • Laktat • Lizofosfatidna kiselina (1,2,3,4,5,6) • Lizofosfolipid (1,2,3,4,5,6,7,8) • Niacin (1,2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1,2,3,4,5) • Sukcinat

Peptid

Neuropeptidni

B/W (1,2) • FF (1,2) • S • Y (1,2,4,5) • Neuromedin (B,U (1,2)) • Neurotenzin (1,2)

Drugi

Anafilatoksin (C3a,C5a) • Angiotenzin (1,2) • Apelin • Bombezin (BRS3,GRPR,NMBR) • Bradikinin (B1,B2) • Hemokin • Holecistokinin (A,B) • Endotelin (A,B) • Formil peptid (1,2,3) • FSH • Galanin (1,2,3) • GHB receptor • Gonadotropin-oslobađajući hormon (1,2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1,1L,D,E,F,G,X1,X2,X3,X4) • Melanokortin (1,2,3,4,5) • MCHR (1,2) • Motilin • Opioidni (δ,κ,μ,Nociceptin &ζ, ali neσ) • Oreksin (1,2) • Oksitocin • Prokineticin (1,2) • Prolaktin-oslobađajući peptid • Relaksin (1,2,3,4) • Somatostatin (1,2,3,4,5) • Tahikinin (1,2,3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A,1B,2)

Razno

Orfan	GPR (1,3,4,6,12,15,17,18,19,20,21,22,23,25,26,27,31,32,33,34,35,37,39,42,44,45,50,52,55,61,62,63,65,68,75,77,78,81,82,83,84,85,87,88,92,101,103,109A,109B,119,120,132,135,137B,139,141,142,146,148,149,150,151,152,153,160,161,162,171,173,174,176,177,182,183)
Drugi	Adrenomedulin • Mirisni • Opsin (3,4,5,1LW,1MW,1SW,RGR,RRH) • Proteazom-aktivirani (1,2,3,4) • SREB (1,2,3)

Klasa B:Sekretinu slični

Orfan

GPR (56,64,97,98,110,111,112,113,114,115,116,123,124,125,126,128,133,143,144,155,157)

Drugi

Moždano specifični angiogenezni inhibitor (1,2,3) • Cadherin (1,2,3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1,2) • EMR (1,2,3) • Glukagon (GR,GIPR,GLP1R,GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1,2,3,ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1,2) • Sekretin • Vazoaktivni intestinalni peptid (1,2)

Klasa C:Metabotropni
glutamat /feromon

Ukus	TAS1R (1,2,3) • TAS2R (1,3,4,5,8,9,10,12,13,14,16,19,20,30,31,38,39,40,41,42,43,45,46,50)
Drugi	Kalcijum-detektujući receptor • GABA B (1,2) • Glutamatni receptor (Metabotropni glutamat (1,2,3,4,5,6,7,8)) • GPRC6A • GPR (156,158,179) • RAIG (1,2,3,4)

Klasa F:
Frizzled /Zaglađeni

Uvojiti	Frizzled (1,2,3,4,5,6,7,8,9,10)
Zaglađeni	Zaglađeni

B trdu:peptidi (nrpl/grfl/cytl/horl),receptori (lgic,enzr,gprc,igsr,intg,nrpr/grfr/cytr),itra (adap,gbpr,mapk),calc,lipd, signalni putevi (hedp,wntp,tgfp+mapp,notp,jakp,fsap,hipp,tlrp)

Izvor:https://sh.wikipedia.org/w/index.php?title=Hormon_rasta_oslobađajući_hormonski_receptor&oldid=42272145

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