Movatterモバイル変換

[0]ホーム

Prijeđi na sadržaj

Glukagonski receptor

Uredi veze

Izvor: Wikipedija

edit

Glukagonski receptor

Dostupne strukture

3CZF

Identifikatori

Simboli

GCGR; GGR

Vanjski ID

OMIM: 138033MGI: 99572HomoloGene: 131IUPHAR:glucagonGeneCards:GCGR Gene

Ontologija gena
Molekularna funkcija	•aktivnost glukagonskog receptora•aktivnost faktora razmene guanil nukleotida•vezivanje peptidnog hormona
Celularna komponenta	•endozom•ćelijska membrana•integralno sa membranom
Biološki proces	•formiranje prekursornih metabolita i energije•metabolički proces energijske rezerve•eksocitoza•signalni put adenilat ciklazom posredovanog G protein spregnutog receptora

Ortolozi

Vrsta

Čovek

Miš

RefSeq (mRNA)

RefSeq (protein)

Lokacija (UCSC)

Chr 17:
79.76 - 79.77 Mb

Chr 11:
120.39 - 120.4 Mb

PubMed pretraga

[1]

[2]

Glukagonski receptor je 62kDa težakprotein koji se aktiviraglukagonom. On je član klase BG protein spregnutih receptora. On formira spregu saG alfa i,G_s i u manjoj meriG alfa q.^[1] Stimulacija receptora dovodi do aktivacijeadenilat ciklaze i povišenja nivoaintracelularnog cAMP. Kod ljudi, glukagonski receptor je kodiranGCGRgenom.^[2]^[3]

Glukagonski receptori su uglavnom izraženi ujetri ibugrezima, i u manjim razmeri usrcu,adipoznom tkivu,slezini,grudnoj žledi,nadbubrežnim žlezdama,pankreasu,cerebralnom korteksu, igastrointestinalnom traktu.

Klinički zanačaj

[uredi |uredi kod]

Jedna od mutacija GCGR gena je vezana zadijabetes melitus tip 2.^[4]

Inaktivirajućamutacija glukagonskog receptora kod ljudi uzrokuje otpornost naglukagon, te je povezana sahiperplazijom pankreasnih alfa ćelija,nezidioblastozom,hiperglukagonemijom, i pankreasnimneuroendokrinim tumorima.^[5]

Reference

[uredi |uredi kod]

↑Brubaker PL, Drucker DJ (2002). „Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors”. Recept. Channels 8 (3-4): 179–88. DOI:10.1080/10606820213687. PMID 12529935.
↑Lok S, Kuijper JL, Jelinek LJ, Kramer JM, Whitmore TE, Sprecher CA, Mathewes S, Grant FJ, Biggs SH, Rosenberg GB (March 1994). „The human glucagon receptor encoding gene: structure, cDNA sequence and chromosomal localization”. Gene 140 (2): 203–9. DOI:10.1016/0378-1119(94)90545-2. PMID 8144028.
↑Menzel S, Stoffel M, Espinosa R, Fernald AA, Le Beau MM, Bell GI (March 1994). „Localization of the glucagon receptor gene to human chromosome band 17q25”. Genomics 20 (2): 327–8. DOI:10.1006/geno.1994.1179. PMID 8020989.
↑Hager J, Hansen L, Vaisse C, Vionnet N, Philippi A, Poller W, Velho G, Carcassi C, Contu L, Julier C (March 1995). „A missense mutation in the glucagon receptor gene is associated with non-insulin-dependent diabetes mellitus”. Nat. Genet. 9 (3): 299–304. DOI:10.1038/ng0395-299. PMID 7773293.
↑Zhou C, Dhall D, Nissen NN, Chen CR, Yu R (2009). „Homozygous P86S mutation of the human glucagon receptor is associated with hyperglucagonemia, alpha cell hyperplasia, and islet cell tumor.”. Pancreas 38 (8): 941–6. DOI:10.1097/MPA.0b013e3181b2bb03. PMC 2767399. PMID 19657311.

Literatura

[uredi |uredi kod]

Levey GS, Weiss SR, Ruiz E (1975). „Characterization of the glucagon receptor in a pheochromocytoma.”. J. Clin. Endocrinol. Metab. 40 (4): 720–3. DOI:10.1210/jcem-40-4-720. PMID 165216.
Nakamura S, Rodbell M (1991). „Glucagon induces disaggregation of polymer-like structures of the alpha subunit of the stimulatory G protein in liver membranes.”. Proc. Natl. Acad. Sci. U.S.A. 88 (16): 7150–4. DOI:10.1073/pnas.88.16.7150. PMC 52251. PMID 1908089.
Horuk R, Wright DE (1983). „Partial purification and characterization of the glucagon receptor.”. FEBS Lett. 155 (2): 213–7. DOI:10.1016/0014-5793(82)80605-4. PMID 6303843.
MacNeil DJ, Occi JL, Hey PJ,et al. (1994). „Cloning and expression of a human glucagon receptor.”. Biochem. Biophys. Res. Commun. 198 (1): 328–34. DOI:10.1006/bbrc.1994.1046. PMID 7507321.
Fujisawa T, Ikegami H, Yamato E,et al. (1995). „A mutation in the glucagon receptor gene (Gly40Ser): heterogeneity in the association with diabetes mellitus.”. Diabetologia 38 (8): 983–5. DOI:10.1007/BF00400589. PMID 7589886.
Unson CG, Macdonald D, Merrifield RB (1993). „The role of histidine-1 in glucagon action.”. Arch. Biochem. Biophys. 300 (2): 747–50. DOI:10.1006/abbi.1993.1103. PMID 8382034.
Chambers SM, Morris BJ (1996). „Glucagon receptor gene mutation in essential hypertension.”. Nat. Genet. 12 (2): 122. DOI:10.1038/ng0296-122. PMID 8563746.
Yamato E, Ikegami H, Takekawa K,et al. (1997). „Tissue-specific and glucose-dependent expression of receptor genes for glucagon and glucagon-like peptide-1 (GLP-1).”. Horm. Metab. Res. 29 (2): 56–9. DOI:10.1055/s-2007-978985. PMID 9105899.
Strazzullo P, Iacone R, Siani A,et al. (2001). „Altered renal sodium handling and hypertension in men carrying the glucagon receptor gene (Gly40Ser) variant.”. J. Mol. Med. 79 (10): 574–80. DOI:10.1007/s001090100257. PMID 11692154.
Shiota D, Kasamatsu T, Dib SA,et al. (2002). „Role of the Gly40Ser mutation in the glucagon receptor gene in Brazilian patients with type 2 diabetes mellitus.”. Pancreas 24 (4): 386–90. DOI:10.1097/00006676-200205000-00010. PMID 11961492.
Strausberg RL, Feingold EA, Grouse LH,et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Runge S, Gram C, Brauner-Osborne H,et al. (2003). „Three distinct epitopes on the extracellular face of the glucagon receptor determine specificity for the glucagon amino terminus.”. J. Biol. Chem. 278 (30): 28005–10. DOI:10.1074/jbc.M301085200. PMID 12724331.
Hassel S, Eichner A, Yakymovych M,et al. (2004). „Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry.”. Proteomics 4 (5): 1346–58. DOI:10.1002/pmic.200300770. PMID 15188402.
Gerhard DS, Wagner L, Feingold EA,et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Mortensen OH, Dichmann DS, Abrahamsen N,et al. (2007). „Identification of a novel human glucagon receptor promoter: regulation by cAMP and PGC-1alpha.”. Gene 393 (1-2): 127–36. DOI:10.1016/j.gene.2007.01.023. PMID 17374560.

Povezano

[uredi |uredi kod]

Glukagonska receptorska familija

Transmembranski receptor:G protein spregnuti receptori

Klasa A:Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A,B,D) • α2 (A,B,C) • β1 • β2 • β3
Purinski	Adenozinski (A1,A2A,A2B,A3) • P2Y (1,2,4,5,6,8,9,10,11,12,13,14)
Serotoninski	(svi osim 5-HT3)5-HT1 (A,B,D,E,F) • 5-HT2 (A,B,C) • 5-HT (4,5A,6,7)
Drugi	Acetilholin (M1,M2,M3,M4,M5) • Dopamin (D1,D2,D3,D4,D5) • Histamin (H1,H2,H3,H4) • Melatonin (1A,1B,1C) • TAAR (1,2,3,5,6,8,9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1,2) • LTB4 (1,2) • FPRL1 • OXE • Prostaglandin (DP (1,2),EP (1,2,3,4),FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1,CB2,GPR (18,55,119)) • EBI2 • Estrogen • Slobodna masna kiselina (1,2,3,4) • Laktat • Lizofosfatidna kiselina (1,2,3,4,5,6) • Lizofosfolipid (1,2,3,4,5,6,7,8) • Niacin (1,2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1,2,3,4,5) • Sukcinat

Peptid

Neuropeptidni

B/W (1,2) • FF (1,2) • S • Y (1,2,4,5) • Neuromedin (B,U (1,2)) • Neurotenzin (1,2)

Drugi

Anafilatoksin (C3a,C5a) • Angiotenzin (1,2) • Apelin • Bombezin (BRS3,GRPR,NMBR) • Bradikinin (B1,B2) • Hemokin • Holecistokinin (A,B) • Endotelin (A,B) • Formil peptid (1,2,3) • FSH • Galanin (1,2,3) • GHB receptor • Gonadotropin-oslobađajući hormon (1,2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1,1L,D,E,F,G,X1,X2,X3,X4) • Melanokortin (1,2,3,4,5) • MCHR (1,2) • Motilin • Opioidni (δ,κ,μ,Nociceptin &ζ, ali neσ) • Oreksin (1,2) • Oksitocin • Prokineticin (1,2) • Prolaktin-oslobađajući peptid • Relaksin (1,2,3,4) • Somatostatin (1,2,3,4,5) • Tahikinin (1,2,3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A,1B,2)

Razno

Orfan	GPR (1,3,4,6,12,15,17,18,19,20,21,22,23,25,26,27,31,32,33,34,35,37,39,42,44,45,50,52,55,61,62,63,65,68,75,77,78,81,82,83,84,85,87,88,92,101,103,109A,109B,119,120,132,135,137B,139,141,142,146,148,149,150,151,152,153,160,161,162,171,173,174,176,177,182,183)
Drugi	Adrenomedulin • Mirisni • Opsin (3,4,5,1LW,1MW,1SW,RGR,RRH) • Proteazom-aktivirani (1,2,3,4) • SREB (1,2,3)

Klasa B:Sekretinu slični

Orfan

GPR (56,64,97,98,110,111,112,113,114,115,116,123,124,125,126,128,133,143,144,155,157)

Drugi

Moždano specifični angiogenezni inhibitor (1,2,3) • Cadherin (1,2,3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1,2) • EMR (1,2,3) • Glukagon (GR,GIPR,GLP1R,GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1,2,3,ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1,2) • Sekretin • Vazoaktivni intestinalni peptid (1,2)

Klasa C:Metabotropni
glutamat /feromon

Ukus	TAS1R (1,2,3) • TAS2R (1,3,4,5,8,9,10,12,13,14,16,19,20,30,31,38,39,40,41,42,43,45,46,50)
Drugi	Kalcijum-detektujući receptor • GABA B (1,2) • Glutamatni receptor (Metabotropni glutamat (1,2,3,4,5,6,7,8)) • GPRC6A • GPR (156,158,179) • RAIG (1,2,3,4)

Klasa F:
Frizzled /Zaglađeni

Uvojiti	Frizzled (1,2,3,4,5,6,7,8,9,10)
Zaglađeni	Zaglađeni

B trdu:peptidi (nrpl/grfl/cytl/horl),receptori (lgic,enzr,gprc,igsr,intg,nrpr/grfr/cytr),itra (adap,gbpr,mapk),calc,lipd, signalni putevi (hedp,wntp,tgfp+mapp,notp,jakp,fsap,hipp,tlrp)

Izvor:https://sh.wikipedia.org/w/index.php?title=Glukagonski_receptor&oldid=42506094

Kategorije:

[8]ページ先頭